Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | glutamine synthetase, putative | 0.0468997 | 0.0110157 | 0.5 |
Echinococcus multilocularis | conserved hypothetical protein | 0.137363 | 0.989762 | 1 |
Leishmania major | glutamine synthetase, putative | 0.0468997 | 0.0110157 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.13831 | 1 | 1 |
Toxoplasma gondii | glutamine synthetase, type I, putative | 0.0927813 | 0.507419 | 0.5 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0468997 | 0.0110157 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | glutamine synthetase | 0.0677796 | 0.23692 | 0.5 |
Onchocerca volvulus | Glutamine synthetase homolog | 0.0468997 | 0.0110157 | 0.5 |
Plasmodium vivax | glutamine synthetase, putative | 0.0927813 | 0.507419 | 0.5 |
Mycobacterium ulcerans | glutamine synthetase | 0.0927813 | 0.507419 | 1 |
Schistosoma mansoni | glutamine synthetase bacteria | 0.0677796 | 0.23692 | 1 |
Plasmodium falciparum | glutamine synthetase, putative | 0.0927813 | 0.507419 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0925218 | 0.504612 | 0.5 |
Mycobacterium leprae | PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) | 0.0927813 | 0.507419 | 1 |
Trypanosoma cruzi | glutamine synthetase, putative | 0.0468997 | 0.0110157 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) | 0.0927813 | 0.507419 | 1 |
Mycobacterium tuberculosis | Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) | 0.0677796 | 0.23692 | 0.466911 |
Schistosoma mansoni | glutamine synthetase bacteria | 0.0677796 | 0.23692 | 1 |
Loa Loa (eye worm) | Gln-2 protein | 0.0468997 | 0.0110157 | 0.5 |
Mycobacterium ulcerans | glutamine synthetase GlnA1 | 0.0927813 | 0.507419 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.17 uM | Antileishmanial activity against Leishmania braziliensis MHOM/IT/2006/ISS2848 promastigotes assessed as inhibition of parasite growth after 72 hrs by MTT assay | ChEMBL. | 25497962 |
IC50 (functional) | = 0.21 uM | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 assessed as inhibition of parasite growth after 72 hrs by parasite lactate dehydrogenase assay | ChEMBL. | 25497962 |
IC50 (functional) | = 0.37 uM | Antileishmanial activity against Leishmania infantum MHOM/TN/80/IPT1 promastigotes assessed as inhibition of parasite growth after 72 hrs by MTT assay | ChEMBL. | 25497962 |
Ratio IC50 (functional) | = 1.3 | Resistance index, ratio of IC50 for chloroquine-resistant Plasmodium falciparum W2 to IC50 for chloroquine-sensitive Plasmodium falciparum D10 | ChEMBL. | 25497962 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 25497962 | |
Leishmania infantum | ChEMBL23 | 25497962 | |
Leishmania braziliensis | ChEMBL23 | 25497962 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.