Detailed information for compound 949218

Basic information

Technical information
  • TDR Targets ID: 949218
  • Name: N-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-pi peridin-1-ylpropanamide
  • MW: 312.449 | Formula: C20H28N2O
  • H donors: 1 H acceptors: 1 LogP: 3.59 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1c2CCCc2cc2c1CCC2)CCN1CCCCC1
  • InChi: 1S/C20H28N2O/c23-19(10-13-22-11-2-1-3-12-22)21-20-17-8-4-6-15(17)14-16-7-5-9-18(16)20/h14H,1-13H2,(H,21,23)
  • InChiKey: XJBWCTRAAVIUIR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-(1-piperidyl)propanamide
  • N-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-piperidino-propionamide
  • N-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)-3-piperidin-1-yl-propanamide
  • AE-641/30117051

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0154 0.1076 0.1107
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0073 0.047 0.3849
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0363 0.0379
Echinococcus multilocularis uridine 5' monophosphate synthase 0.0044 0.0255 0.0247
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0071 0.0052
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0531 0.0536
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0058 0.0363 0.036
Schistosoma mansoni cell polarity protein 0.0141 0.0977 0.1004
Onchocerca volvulus Putative eukaryotic translation initiation factor 4e 0.0154 0.1076 0.8072
Wolbachia endosymbiont of Brugia malayi amidophosphoribosyltransferase 0.0044 0.0255 0.1643
Trichomonas vaginalis conserved hypothetical protein 0.0154 0.1076 0.1107
Trypanosoma brucei Eukaryotic translation initiation factor 4E-4 0.0154 0.1076 0.1058
Loa Loa (eye worm) orotate phosphoribosyltransferase 0.0044 0.0255 0.0236
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0073 0.047 0.3049
Loa Loa (eye worm) PDE1B protein 0.0148 0.1032 0.1015
Trypanosoma cruzi GMP reductase 0.0154 0.1072 0.1103
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0096 0.0101
Loa Loa (eye worm) hypothetical protein 0.0058 0.0363 0.0345
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0384 0.0383
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0531 0.0536
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0188 0.1329 0.1371
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0154 0.1072 1
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0071 0.0055
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0071 0.0055
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0096 0.0024
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0022 0.0094 0.0079
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0044 0.0255 0.0193
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.1292 0.9571 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0363 0.0345
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0058 0.0363 0.036
Mycobacterium ulcerans hypoxanthine-guanine phosphoribosyltransferase Hpt 0.0188 0.1329 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0148 0.1032 0.1061
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Trichomonas vaginalis ribose-phosphate pyrophosphokinase, putative 0.0044 0.0255 0.0247
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0058 0.0363 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0154 0.1076 0.1107
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0071 0.0055
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0188 0.1329 0.1371
Onchocerca volvulus 0.0017 0.0055 0.0277
Mycobacterium ulcerans bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 0.0044 0.0255 0.1301
Treponema pallidum phosphoribosylpyrophosphate synthetase 0.0044 0.0255 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0058 0.0363 0.036
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0071 0.0055
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0052
Trypanosoma brucei Eukaryotic translation initiation factor 4E type 5 0.0154 0.1076 0.1058
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0058 0.0363 0.036
Brugia malayi eukaryotic translation initiation factor 4E-1 0.0154 0.1076 0.1059
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.171 0.177
Mycobacterium tuberculosis Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase) 0.0044 0.0255 0.1643
Giardia lamblia Adenine phosphoribosyltransferase 0.0044 0.0255 0.1801
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.1292 0.9571 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0036
Plasmodium vivax hypothetical protein, conserved 0.0154 0.1076 0.81
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0154 0.1076 0.1124
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0363 0.0379
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Entamoeba histolytica Rho family GTPase 0.0012 0.0019 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0363 0.036
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0071 0.0055
Loa Loa (eye worm) IMP dehydrogenase 1 0.0154 0.1072 0.1055
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0154 0.1076 0.1107
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0384 0.0346
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.0071 0.0055
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0154 0.1076 0.1107
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0071 0.0055
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0096 0.0027
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0363 0.036
Trichomonas vaginalis receptor histidine kinase, putative 0.0022 0.0094 0.0079
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0363 0.0379
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0058 0.0363 0.036
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0363 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0363 0.036
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0058 0.0363 0.036
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.0071 0.0052
Mycobacterium tuberculosis Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor 0.0144 0.1 0.9268
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0154 0.1072 1
Brugia malayi translation initiation factor 4E 0.1292 0.9571 0.957
Echinococcus granulosus adenine phosphoribosyltransferase 0.0044 0.0255 0.0247
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0363 0.0379
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.0071 0.0055
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0071 0.0055
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0144 0.1004 0.7369
Loa Loa (eye worm) GMP reductase 0.0064 0.0402 0.0384
Mycobacterium tuberculosis Conserved hypothetical protein 0.0111 0.0754 0.6749
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0058 0.0363 0.036
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0071 0.0052
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0071 0.0055
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0188 0.1329 0.1324
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0071 0.0055
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0363 0.036
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0096 0.0024
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0148 0.1032 0.1061
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0096 0.0019
Brugia malayi PXA domain containing protein 0.0019 0.0071 0.0052
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0044 0.0255 0.0247
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0058 0.0363 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0071 0.0055
Echinococcus granulosus tissue type plasminogen activator 0.0017 0.0055 0.0038
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0384 0.235
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.1292 0.9571 1
Echinococcus granulosus ras gtpase 0.0141 0.0977 0.1004
Brugia malayi Kringle domain containing protein 0.0017 0.0055 0.0036
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0188 0.1329 0.1371
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0071 0.0052
Echinococcus multilocularis adenine phosphoribosyltransferase 0.0044 0.0255 0.0247
Brugia malayi GTP-binding protein 0.0141 0.0977 0.0961
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0188 0.1329 0.1371
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0052
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0071 0.0055
Entamoeba histolytica Rho family GTPase 0.0012 0.0019 0.002
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0071 0.0055
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0071 0.0055
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0044 0.0255 0.0247
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0058 0.0363 0.2416
Loa Loa (eye worm) GTP-binding protein 0.0141 0.0977 0.0961
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0096 0.0324
Leishmania major xanthine phosphoribosyltransferase 0.0188 0.1329 0.1338
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0058 0.0363 0.036
Mycobacterium tuberculosis Conserved hypothetical protein 0.0044 0.0255 0.1643
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0058 0.0363 0.036
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0071 0.0055
Schistosoma mansoni DNA helicase recq5 0.0019 0.0071 0.0055
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0052
Brugia malayi GTP-binding protein, identical 0.0141 0.0977 0.0961
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0148 0.1032 0.1061
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0154 0.1076 0.1107
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0071 0.0125
Toxoplasma gondii hypothetical protein 0.0154 0.1076 0.1124
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0154 0.1076 0.1107
Toxoplasma gondii IMP dehydrogenas 0.0154 0.1072 0.112
Loa Loa (eye worm) eukaryotic translation initiation factor 4E-1 0.0154 0.1076 0.1059
Mycobacterium tuberculosis Conserved protein 0.0044 0.0255 0.1643
Loa Loa (eye worm) hypothetical protein 0.0239 0.171 0.1694
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.1292 0.9571 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0058 0.0363 0.036
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0531 0.0536
Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase 0.0188 0.1329 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0363 0.036
Mycobacterium ulcerans amidophosphoribosyltransferase 0.0044 0.0255 0.1301
Leishmania major hypothetical protein, conserved 0.0154 0.1076 0.1073
Treponema pallidum adenine phosphoribosyltransferase 0.0044 0.0255 1
Schistosoma mansoni cell polarity protein 0.0141 0.0977 0.1004
Brugia malayi Phosphoribosyl transferase domain containing protein 0.0188 0.1329 0.1312
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.1292 0.9571 1
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0064 0.0402 0.0384
Leishmania major eukaryotic translation initiation factor-like 0.1292 0.9571 1
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0058 0.0363 0.273
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0058 0.0363 0.036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0052
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0188 0.1329 0.1324
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0058 0.0363 0.036
Leishmania major eukaryotic translation initiation factor, putative 0.0154 0.1076 0.1073
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.1292 0.9571 1
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0188 0.1329 0.1371
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Leishmania major hypothetical protein, conserved 0.0058 0.0363 0.0323
Echinococcus multilocularis bloom syndrome protein 0.0019 0.0071 0.0055
Brugia malayi PXA domain containing protein 0.0019 0.0071 0.0052
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0148 0.1032 0.1015
Trichomonas vaginalis receptor histidine kinase, putative 0.0022 0.0094 0.0079
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0363 0.0379
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0154 0.1076 0.1107
Loa Loa (eye worm) hypothetical protein 0.135 1 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.0282 0.2029 0.2075
Echinococcus granulosus eukaryotic translation initiation factor 4E type 0.0154 0.1076 0.1107
Mycobacterium tuberculosis Conserved hypothetical protein 0.0111 0.0754 0.6749
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0148 0.1032 0.1061
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0081 0.053 0.0536
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0148 0.1032 0.1078
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0071 0.0055
Loa Loa (eye worm) eukaryotic translation initiation factor 4E type 3 0.0154 0.1076 0.1059
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0071 0.0055
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0058 0.0363 0.036
Mycobacterium leprae conserved hypothetical protein 0.0111 0.0754 0.6749
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0154 0.1076 0.1107
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0044 0.0255 0.0247
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0058 0.0363 0.036
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0363 0.0379
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0154 0.1072 0.1103
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0058 0.0363 0.036
Entamoeba histolytica hypothetical protein 0.0023 0.0096 0.0101
Giardia lamblia Translation elongation factor 0.0154 0.1076 0.8072
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0071 0.0055
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.0071 0.0055
Leishmania major eukaryotic translation initiation factor 4e, putative 0.0154 0.1076 0.1073
Giardia lamblia Hypothetical protein 0.0154 0.1076 0.8072
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0363 0.0379
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0154 0.1076 0.1124
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0148 0.1032 0.1061
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0052
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0363 0.0307
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-3 0.0154 0.1076 0.1107
Mycobacterium tuberculosis Probable pyrimidine operon regulatory protein PyrR 0.0044 0.0255 0.1643
Onchocerca volvulus 0.0188 0.1329 1
Mycobacterium tuberculosis Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase) 0.0044 0.0255 0.1643
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0154 0.1076 0.1107
Leishmania major orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative 0.0044 0.0255 0.021
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0363 0.273
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0071 0.0052
Entamoeba histolytica recQ family helicase, putative 0.0019 0.0071 0.0074
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0071 0.0055
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0058 0.0363 0.036
Brugia malayi Adenine phosphoribosyltransferase 0.0044 0.0255 0.0236
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0096 0.0043
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0058 0.0363 0.036
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0384 0.0383
Trichomonas vaginalis hypoxanthine-guanine phosphoribosyltransferase, putative 0.0188 0.1329 0.1371
Trypanosoma cruzi GMP reductase 0.0154 0.1072 0.1103
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Plasmodium falciparum orotate phosphoribosyltransferase 0.0044 0.0255 0.1567
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0363 0.036
Mycobacterium leprae PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE) 0.0044 0.0255 0.1643
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0384 0.0401
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0384 0.235
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0017 0.0055 0.0414
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0044 0.0255 0.0247
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0071 0.0052
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0188 0.1329 0.1371
Plasmodium falciparum phosphodiesterase gamma, putative 0.0058 0.0363 0.2416
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0071 0.0055
Toxoplasma gondii kringle domain-containing protein 0.0017 0.0055 0.0057
Mycobacterium leprae conserved hypothetical protein 0.0111 0.0754 0.6749
Entamoeba histolytica Rho family GTPase 0.0012 0.0019 0.002
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.1292 0.9571 1
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0071 0.0055
Mycobacterium leprae AMIDOPHOSPHORIBOSYLTRANSFERASE PURF (GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE) (ATASE) (GPATASE) 0.0044 0.0255 0.1643
Entamoeba histolytica Rho family GTPase 0.0012 0.0019 0.002
Wolbachia endosymbiont of Brugia malayi orotate phosphoribosyltransferase 0.0044 0.0255 0.1643
Brugia malayi Protein kinase domain containing protein 0.0017 0.0055 0.0036
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0058 0.0363 0.036
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0058 0.0363 0.0345
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0188 0.1329 0.1371
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0363 0.0379
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0058 0.0363 0.036
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0096 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0071 0.0055
Leishmania major hypothetical protein, conserved 0.0154 0.1076 0.1073
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0363 0.036
Echinococcus granulosus expressed protein 0.0377 0.2741 0.285
Trypanosoma brucei hypothetical protein, conserved 0.0058 0.0363 0.0307
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0363 0.036
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0071 0.0055
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0363 0.0379
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0148 0.1032 0.1012
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0058 0.0363 0.036
Trypanosoma brucei orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0044 0.0255 0.0193
Leishmania major adenine phosphoribosyltransferase 0.0044 0.0255 0.021
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0058 0.0363 0.036
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.1292 0.9571 1
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0081 0.0528 0.4436
Onchocerca volvulus Putative GMP reductase 0.0064 0.0402 0.2929
Entamoeba histolytica hypothetical protein 0.0019 0.0071 0.0074
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0363 0.036
Loa Loa (eye worm) adenine phosphoribosyltransferase 0.0044 0.0255 0.0236
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.0071 0.0399
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0058 0.0363 0.036
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0071 0.0052
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0058 0.0363 0.0307
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0363 0.036
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0384 0.0383
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0363 0.036
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0044 0.0255 0.0247
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0052
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.0071 0.0052
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0071 0.0055
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0154 0.1072 0.792
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0071 0.0055
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0071 0.0052
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0154 0.1076 0.1107
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0081 0.0528 0.4436
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0044 0.0255 0.0247
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0044 0.0255 0.0247
Entamoeba histolytica translation initiation factor 4e, putative 0.0154 0.1076 0.1124
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0363 0.0379
Trichomonas vaginalis sensor histidine kinase, putative 0.0022 0.0094 0.0079
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0363 0.0379
Loa Loa (eye worm) hypothetical protein 0.1291 0.9564 0.9563
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0154 0.1076 0.1107
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase, putative 0.0188 0.1329 0.1324
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0071 0.0052
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0154 0.1076 0.1124
Leishmania major hypothetical protein, conserved 0.0058 0.0363 0.0323
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0071 0.0055
Onchocerca volvulus 0.0049 0.029 0.2071
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0022 0.0094 0.0079
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.1292 0.9571 1
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0064 0.0402 0.0384
Entamoeba histolytica hypothetical protein 0.0019 0.0071 0.0074
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0058 0.0363 0.036
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0071 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0071 0.0055
Brugia malayi orotate phosphoribosyltransferase family protein 0.0044 0.0255 0.0236
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0363 0.036
Leishmania major hypoxanthine-guanine phosphoribosyltransferase 0.0188 0.1329 0.1338
Giardia lamblia hypothetical protein 0.0058 0.0363 0.2626
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0071 0.0074
Echinococcus granulosus uridine 5' monophosphate synthase 0.0044 0.0255 0.0247
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0058 0.0363 0.0345
Leishmania major inosine-5-monophosphate dehydrogenase 0.0154 0.1072 0.1069
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0058 0.0363 0.036
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0096 0.0019
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0058 0.0363 0.0345
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0096 0.0147
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0154 0.1076 0.1107
Giardia lamblia Guanine phosphoribosyltransferase 0.0188 0.1329 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0363 0.0345
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0188 0.1329 0.1371
Schistosoma mansoni hypothetical protein 0.0017 0.0055 0.0038
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0154 0.1076 0.1124
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0154 0.1072 0.1103
Trypanosoma brucei Eukaryotic translation initiation factor 4E-2 0.0154 0.1076 0.1058
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.029 0.0272
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0363 0.036
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0071 0.0055
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0154 0.1072 0.1055
Loa Loa (eye worm) RecQ helicase 0.0019 0.0071 0.0052
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0058 0.0363 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0071 0.0055
Mycobacterium tuberculosis Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase) 0.0044 0.0255 0.1643
Schistosoma mansoni uracil phosphoribosyltransferase 0.0044 0.0255 0.0247
Mycobacterium ulcerans adenine phosphoribosyltransferase 0.0044 0.0255 0.1301
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0154 0.1076 0.1107
Schistosoma mansoni DNA helicase recq1 0.0019 0.0071 0.0055
Plasmodium vivax orotate phosphoribosyltransferase, putative 0.0044 0.0255 0.1916
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.1292 0.9571 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0096 0.0725
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0071 0.0055
Schistosoma mansoni hypothetical protein 0.0049 0.029 0.0284
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0044 0.0255 0.0247
Brugia malayi Eukaryotic translation initiation factor 4E type 3, putative 0.0154 0.1076 0.1059
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.0071 0.0055
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0154 0.1072 0.1103
Brugia malayi hypothetical protein 0.0019 0.0071 0.0052
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0188 0.1329 0.1371
Trichomonas vaginalis Ribose-phosphate pyrophosphokinase, putative 0.0044 0.0255 0.0247
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0055 0.0038
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.171 0.177
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0022 0.0094 0.0079
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0058 0.0363 0.0345
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0044 0.0255 0.0193
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0363 0.036
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Schistosoma mansoni orotidine 5'-phosphate decarboxylase 0.0044 0.0255 0.0247
Trypanosoma brucei GMP reductase 0.0154 0.1072 0.1054
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.0071 0.0055
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0148 0.1032 0.7767
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0363 0.2416
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0363 0.2416
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Echinococcus multilocularis ras gtpase 0.0141 0.0977 0.1004
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0058 0.0363 0.036
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0058 0.0363 0.2416
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0058 0.0363 0.0345
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0044 0.0255 0.0247
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0148 0.1032 0.1061
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0096 0.0101
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0058 0.0363 0.036
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0071 0.0055
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0384 0.0383
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0363 0.036
Giardia lamblia Hypothetical protein 0.0058 0.0363 0.2626
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0154 0.1072 0.1054
Brugia malayi GMP reductase 0.0064 0.0402 0.0384
Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT 0.0188 0.1329 0.1388
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0144 0.1004 0.745
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0154 0.1076 0.1107
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0071 0.0055
Leishmania major eukaryotic translation initiation factor-like protein 0.1292 0.9571 1
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0044 0.0255 0.0247
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0071 0.0055
Plasmodium falciparum eukaryotic translation initiation factor 4E 0.0154 0.1076 0.8017
Plasmodium vivax translation initiation factor 4E, putative 0.0154 0.1076 0.81
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0058 0.0363 0.036
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.1292 0.9571 1
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0154 0.1076 0.1124
Entamoeba histolytica hypothetical protein 0.0019 0.0071 0.0074
Brugia malayi hypothetical protein 0.0019 0.0071 0.0052
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0363 0.0379
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0071 0.0055
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0363 0.0379
Plasmodium vivax phosphodiesterase gamma, putative 0.0058 0.0363 0.273
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0058 0.0363 0.036
Onchocerca volvulus 0.0081 0.0531 0.3911
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.0071 0.0017
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0058 0.0363 0.2626
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0154 0.1076 0.1124
Entamoeba histolytica hypothetical protein 0.0154 0.1076 0.1124
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0148 0.1032 0.1061
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0363 0.036
Entamoeba histolytica hypothetical protein 0.0154 0.1076 0.1124
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0058 0.0363 0.036
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0058 0.0363 0.0307
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Plasmodium falciparum phosphodiesterase delta, putative 0.0058 0.0363 0.2416
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0019 0.0071 0.0125
Schistosoma mansoni sensor histidine kinase/response regulator 0.0022 0.0094 0.0079
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0071 0.0052
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0071 0.0055
Loa Loa (eye worm) hypothetical protein 0.0019 0.0071 0.0052
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0148 0.1032 0.1078
Mycobacterium leprae Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho 0.0144 0.1 0.9268
Onchocerca volvulus Adenine phosphoribosyltransferase homolog 0.0044 0.0255 0.1801
Mycobacterium tuberculosis Conserved protein 0.0044 0.0255 0.1643
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0022 0.0094 0.0079
Brugia malayi hypothetical protein 0.0239 0.171 0.1694
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0363 0.0379
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0282 0.2029 0.2062
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0154 0.1072 0.1103
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0154 0.1076 0.1107
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0188 0.1329 0.1371
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0144 0.1004 0.7555
Loa Loa (eye worm) translation initiation factor 4E 0.1292 0.9571 0.957
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0363 0.0307
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0071 0.0052
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.0071 0.0055
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0154 0.1076 0.1107
Echinococcus multilocularis expressed protein 0.0377 0.2741 0.285
Mycobacterium ulcerans hypothetical protein 0.0044 0.0255 0.1301
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0363 0.0379
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0096 1
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0071 0.0052
Echinococcus multilocularis tissue type plasminogen activator 0.0017 0.0055 0.0038
Leishmania major guanosine monophosphate reductase 0.0154 0.1072 0.1069
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.1292 0.9571 1
Giardia lamblia Hypothetical protein 0.0154 0.1076 0.8072
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0071 0.0055
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0071 0.0055
Plasmodium falciparum eukaryotic translation initiation factor 4E, putative 0.0154 0.1076 0.8017
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0154 0.1076 0.1107
Entamoeba histolytica Rho family GTPase 0.0012 0.0019 0.002
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0071 0.0074
Trypanosoma brucei Eukaryotic translation initiation factor 4E-3 0.0154 0.1076 0.1058
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0071 0.0055
Trichomonas vaginalis sensor histidine kinase, putative 0.0022 0.0094 0.0079
Mycobacterium ulcerans orotate phosphoribosyltransferase 0.0044 0.0255 0.1301
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0154 0.1076 0.1107
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0384 0.235
Entamoeba histolytica Rho family GTPase 0.0012 0.0019 0.002
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.1292 0.9571 1
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0071 0.0055
Giardia lamblia hypothetical protein 0.0154 0.1076 0.8072
Toxoplasma gondii orotate phosphoribosyltransferase 0.0044 0.0255 0.0266
Loa Loa (eye worm) hypothetical protein 0.0081 0.0531 0.0513
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0071 0.0052
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase, putative 0.0188 0.1329 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0363 0.0379
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0058 0.0363 0.036
Loa Loa (eye worm) TK/ROR protein kinase 0.0017 0.0055 0.0036
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0058 0.0363 0.036
Schistosoma mansoni survival motor neuron protein 0.0049 0.029 0.0284
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0282 0.2029 0.2105
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0154 0.1076 0.1107
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0154 0.1076 0.1107
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0058 0.0363 0.036
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0071 0.0055
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0363 0.036
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0071 0.0052
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0148 0.1032 0.1027
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0071 0.0055
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0154 0.1072 1
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0071 0.0055
Trichomonas vaginalis hypothetical protein 0.0154 0.1076 0.1107
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0154 0.1072 0.1103
Echinococcus granulosus bloom syndrome protein 0.0019 0.0071 0.0055
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0154 0.1076 0.1107
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0531 0.0513
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0384 0.2968
Treponema pallidum hypothetical protein 0.0044 0.0255 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0154 0.1072 0.1103
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.1292 0.9571 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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