TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 917.048 | Formula: C49H62F2N6O9
H donors: 3 H acceptors: 5 LogP: 5.13 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: COC(=O)[C@@]1(C[C@@H]2CN(CCc3c1[nH]c1c3cc(cc1)NC(=O)N(C)C)C[C@@H](C2)C(F)(F)C)c1cc2c(cc1OC)N([C@@H]1[C@@]32CCN2[C@H]3[C@@]([C@H]([C@]1(O)C(=O)OC)OC(=O)C)(CC)C=CC2)C
InChi: 1S/C49H62F2N6O9/c1-10-46-15-11-17-57-19-16-47(39(46)57)33-22-34(37(63-7)23-36(33)55(6)40(47)49(62,43(60)65-9)41(46)66-27(2)58)48(42(59)64-8)24-28-20-29(45(3,50)51)26-56(25-28)18-14-31-32-21-30(52-44(61)54(4)5)12-13-35(32)53-38(31)48/h11-13,15,21-23,28-29,39-41,53,62H,10,14,16-20,24-26H2,1-9H3,(H,52,61)/t28-,29-,39+,40-,41-,46-,47-,48+,49+/m1/s1
InChiKey: OGIDMPJSVXVDFP-ZJJDQQAPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0352	0.1814	0.0572
Echinococcus granulosus	cysteine protease	0.0925	0.5133	0.5119
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0102	0.0102
Entamoeba histolytica	cysteine proteinase 2	0.0925	0.5133	0.4054
Leishmania major	cysteine peptidase A (CPA)	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0352	0.1814	0.0572
Trypanosoma cruzi	cruzipain precursor, putative	0.0573	0.3097	0.1568
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0352	0.1814	0.1814
Brugia malayi	cathepsin F-like cysteine proteinase	0.0352	0.1814	0.1814
Leishmania major	cathepsin L-like protease	0.1766	1	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0352	0.1814	0.1814
Loa Loa (eye worm)	hypothetical protein	0.1766	1	1
Echinococcus multilocularis	cathepsin b	0.1373	0.7729	0.7722
Echinococcus multilocularis	cathepsin L	0.0352	0.1814	0.1791
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0352	0.1814	0.0572
Entamoeba histolytica	cysteine proteinase 1, putative	0.0925	0.5133	0.4054
Onchocerca volvulus		0.1766	1	1
Plasmodium vivax	vivapain-2	0.1766	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0925	0.5133	0.2343
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0352	0.1814	0.0572
Trypanosoma cruzi	cysteine proteinase, putative	0.0925	0.5133	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.1766	1	1
Schistosoma mansoni	inositol transporter	0.0043	0.0028	0.0028
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0352	0.1814	0.0572
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.0102	0.0102
Loa Loa (eye worm)	hypothetical protein	0.1373	0.7729	0.7729
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Echinococcus granulosus	cathepsin l1	0.1192	0.6681	0.6672
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0352	0.1814	0.0572
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0925	0.5133	0.4394
Trypanosoma cruzi	cysteine peptidase, putative	0.1766	1	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0925	0.5133	0.4054
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.091	0.5045	0.5032
Echinococcus granulosus	cathepsin b	0.1373	0.7729	0.7722
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1766	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1766	1	1
Onchocerca volvulus		0.1766	1	1
Loa Loa (eye worm)	cathepsin B	0.0668	0.3643	0.3643
Entamoeba histolytica	cysteine proteinase, putative	0.1766	1	1
Leishmania major	cathepsin L-like protease	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.1766	1	1
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0352	0.1814	0.1814
Entamoeba histolytica	cysteine proteinase, putative	0.1766	1	1
Schistosoma mansoni	high-affinity choline transporter	0.039	0.2036	0.2036
Toxoplasma gondii	cathepsin CPL	0.1766	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0668	0.3643	0.3643
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1192	0.6681	0.6178
Trypanosoma cruzi	cysteine peptidase, putative	0.1766	1	1
Loa Loa (eye worm)	fibroinase	0.1766	1	1
Loa Loa (eye worm)	ctsf protein	0.1766	1	1
Onchocerca volvulus		0.1766	1	1
Leishmania major	cathepsin L-like protease	0.1766	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0352	0.1814	0.0572
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0352	0.1814	0.0572
Echinococcus multilocularis	high affinity choline transporter 1	0.039	0.2036	0.2014
Loa Loa (eye worm)	hypothetical protein	0.0352	0.1814	0.1814
Schistosoma mansoni	cathepsin C	0.0352	0.1814	0.1814
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.1192	0.6681	0.5946
Entamoeba histolytica	cysteine protease, putative	0.1766	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0352	0.1814	0.1814
Loa Loa (eye worm)	hypothetical protein	0.0573	0.3097	0.3097
Echinococcus granulosus	cathepsin l1	0.1766	1	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0352	0.1814	0.1814
Trypanosoma cruzi	cysteine peptidase, putative	0.0925	0.5133	0.4054
Onchocerca volvulus		0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1766	1	1
Brugia malayi	GH02984p	0.039	0.2036	0.2036
Brugia malayi	Cathepsin L-like precursor	0.1192	0.6681	0.6681
Brugia malayi	Cathepsin L-like precursor	0.0573	0.3097	0.3097
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0352	0.1814	0.1814
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0925	0.5133	0.5133
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0352	0.1814	0.1814
Brugia malayi	cathepsin L-like precursor	0.1192	0.6681	0.6681
Schistosoma mansoni	cathepsin F (C01 family)	0.1192	0.6681	0.6681
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1373	0.7729	0.7729
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Onchocerca volvulus		0.0266	0.1317	0.1293
Loa Loa (eye worm)	hypothetical protein	0.1192	0.6681	0.6681
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0668	0.3643	0.2235
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Plasmodium vivax	unspecified product	0.0925	0.5133	0.4054
Plasmodium vivax	vivapain-1	0.0925	0.5133	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0352	0.1814	0.0572
Brugia malayi	Pre-SET motif family protein	0.0233	0.113	0.113
Giardia lamblia	Cathepsin B precursor	0.0668	0.3643	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1192	0.6681	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Echinococcus granulosus	cathepsin L	0.0352	0.1814	0.1791
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Leishmania major	cathepsin L-like protease	0.1766	1	1
Onchocerca volvulus		0.1192	0.6681	0.6672
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0352	0.1814	0.1814
Loa Loa (eye worm)	hypothetical protein	0.0573	0.3097	0.3097
Brugia malayi	Papain family cysteine protease containing protein	0.1766	1	1
Echinococcus multilocularis	cathepsin L	0.0925	0.5133	0.5119
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1373	0.7729	0.7729
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0925	0.5133	0.4394
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Leishmania major	cathepsin L-like protease	0.1766	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1373	0.7729	0.7729
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1192	0.6681	0.6681
Brugia malayi	Sodium:solute symporter family protein	0.0043	0.0028	0.0028
Trypanosoma cruzi	cysteine proteinase, putative	0.0925	0.5133	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Loa Loa (eye worm)	hypothetical protein	0.1192	0.6681	0.6681
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0233	0.113	0.113
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.0102	0.0102
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0573	0.3097	0.3097
Schistosoma mansoni	cathepsin s	0.0573	0.3097	0.3097
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1766	1	1
Onchocerca volvulus		0.1766	1	1
Onchocerca volvulus		0.1766	1	1
Loa Loa (eye worm)	hypothetical protein	0.1192	0.6681	0.6681
Onchocerca volvulus		0.0352	0.1814	0.1791
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0352	0.1814	0.0572
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1766	1	1
Toxoplasma gondii	cathepsin B	0.0668	0.3643	0.3626
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Echinococcus granulosus	cathepsin b	0.1373	0.7729	0.7722
Loa Loa (eye worm)	hypothetical protein	0.0352	0.1814	0.1814
Entamoeba histolytica	cysteine proteinase, putative	0.0925	0.5133	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0925	0.5133	0.4054
Leishmania major	cathepsin L-like protease	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1766	1	1
Leishmania major	cathepsin L-like protease	0.1766	1	1
Brugia malayi	Cathepsin L-like precursor	0.1192	0.6681	0.6681
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0352	0.1814	0.1791
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Echinococcus granulosus	high affinity choline transporter 1	0.039	0.2036	0.2014
Brugia malayi	Papain family cysteine protease containing protein	0.0925	0.5133	0.5133
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0573	0.3097	0.3097
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0352	0.1814	0.0572
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0352	0.1814	0.0572
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0925	0.5133	0.4054
Schistosoma mansoni	sodium/solute symporter	0.0043	0.0028	0.0028
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Brugia malayi	Cathepsin L-like precursor	0.1766	1	1
Loa Loa (eye worm)	hypothetical protein	0.0352	0.1814	0.1814
Brugia malayi	cathepsin F-like cysteine proteinase	0.0573	0.3097	0.3097
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0352	0.1814	0.0572
Onchocerca volvulus	Cathepsin L homolog	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1766	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0352	0.1814	0.1814
Brugia malayi	Cathepsin L-like precursor	0.1766	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0028	0.0028
Entamoeba histolytica	cysteine proteinase, putative	0.0925	0.5133	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0668	0.3643	0.2679
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0352	0.1814	0.1814
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0573	0.3097	0.1568
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0925	0.5133	0.2343
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Brugia malayi	Cathepsin L-like precursor	0.1766	1	1
Plasmodium vivax	vivapain-2	0.1766	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1373	0.7729	0.7729
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1766	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.1766	1	1
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Giardia lamblia	Cathepsin B precursor	0.0668	0.3643	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Loa Loa (eye worm)	hypothetical protein	0.0352	0.1814	0.1814
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0352	0.1814	0.1814
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0352	0.1814	0.1814
Brugia malayi	Cathepsin L-like precursor	0.1766	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0352	0.1814	0.1814
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1766	1	1
Brugia malayi	fibroinase precursor	0.0352	0.1814	0.1814
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0352	0.1814	0.1814
Plasmodium vivax	unspecified product	0.0573	0.3097	0.1568
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.0102	0.0102
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1766	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Loa Loa (eye worm)	hypothetical protein	0.0352	0.1814	0.1814
Onchocerca volvulus	Cathepsin L homolog	0.0352	0.1814	0.1791
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0352	0.1814	0.1814
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1766	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0925	0.5133	0.4054
Brugia malayi	cathepsin L-like cysteine proteinase	0.0352	0.1814	0.1814
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0352	0.1814	0.0572
Brugia malayi	Papain family cysteine protease containing protein	0.0352	0.1814	0.1814
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0352	0.1814	0.0572
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1766	1	1
Loa Loa (eye worm)	hypothetical protein	0.0352	0.1814	0.1814
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Loa Loa (eye worm)	hypothetical protein	0.039	0.2036	0.2036
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0352	0.1814	0.0572
Echinococcus multilocularis	cysteine protease	0.1766	1	1
Brugia malayi	Cathepsin L-like precursor	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Onchocerca volvulus	Cathepsin L homolog	0.1766	1	1
Toxoplasma gondii	cathepsin CPC2	0.0352	0.1814	0.1791
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0925	0.5133	0.5133
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0352	0.1814	0.0572
Schistosoma mansoni	inositol transporter	0.0043	0.0028	0.0028
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1192	0.6681	0.6178
Echinococcus granulosus	cathepsin L	0.0925	0.5133	0.5119
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1766	1	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.1373	0.7729	0.7729
Echinococcus multilocularis	cysteine protease	0.1766	1	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0352	0.1814	0.1814
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1373	0.7729	0.7225
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1766	1	1
Onchocerca volvulus	Cathepsin F homolog	0.1766	1	1
Loa Loa (eye worm)	hypothetical protein	0.0573	0.3097	0.3097
Echinococcus granulosus	cathepsin L cysteine protease	0.0925	0.5133	0.5119
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1766	1	1
Toxoplasma gondii	cathepsin CPC1	0.0352	0.1814	0.1791
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Trypanosoma cruzi	cruzipain precursor, putative	0.1766	1	1
Giardia lamblia	Cathepsin B precursor	0.0668	0.3643	1
Leishmania major	cathepsin L-like protease	0.1766	1	1
Trypanosoma cruzi	cysteine protease, putative	0.0925	0.5133	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0352	0.1814	0.1814
Brugia malayi	Papain family cysteine protease containing protein	0.0925	0.5133	0.5133
Plasmodium vivax	vivapain-3	0.0925	0.5133	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1766	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0352	0.1814	0.0572
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0925	0.5133	0.5133
Brugia malayi	Papain family cysteine protease containing protein	0.0352	0.1814	0.1814
Onchocerca volvulus		0.1766	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1766	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1766	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0352	0.1814	0.1814
Loa Loa (eye worm)	cysteine protease	0.1766	1	1
Echinococcus multilocularis	cathepsin b	0.1373	0.7729	0.7722
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0352	0.1814	0.0572
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1766	1	1
Entamoeba histolytica	cysteine protease, putative	0.0925	0.5133	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1766	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1766	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1766	1	1
Brugia malayi	cathepsin L precursor	0.0352	0.1814	0.1814

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 100 uM	Cytotoxicity against human A549 cells by SRB assay	ChEMBL.	18653334

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL446507

Bibliographic References

No literature references available for this target.

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Detailed information for compound 953509