Detailed information for compound 954328

Basic information

Technical information
  • TDR Targets ID: 954328
  • Name: 3-(4-hydroxyphenyl)-5,7-dimethoxychromen-4-on e
  • MW: 298.29 | Formula: C17H14O5
  • H donors: 1 H acceptors: 2 LogP: 2.77 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)cc2c1c(=O)c(co2)c1ccc(cc1)O
  • InChi: 1S/C17H14O5/c1-20-12-7-14(21-2)16-15(8-12)22-9-13(17(16)19)10-3-5-11(18)6-4-10/h3-9,18H,1-2H3
  • InChiKey: YZBVKMUAJDLNMZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-hydroxyphenyl)-5,7-dimethoxy-chromen-4-one
  • 3-(4-hydroxyphenyl)-5,7-dimethoxy-4-chromenone
  • 3-(4-hydroxyphenyl)-5,7-dimethoxy-chromone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii aspartyl protease ASP1 0.0147 0.0705 1
Trypanosoma brucei unspecified product 0.0039 0.0107 0.3166
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0045 0.0137 0.0124
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.002 0.0013
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0101 0.045 0.1314
Plasmodium vivax aspartyl proteinase, putative 0.0147 0.0705 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0047 0.0291
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0068 0.0268 0.2249
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0076 0.0307 0.1158
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0147 0.0705 0.0692
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0107 0.3166
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0125 0.0112
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0045 0.0137 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.002 0.0018
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0149 0.0518
Schistosoma mansoni thyroid hormone receptor 0.0024 0.002 0.0006
Echinococcus granulosus geminin 0.0205 0.1024 0.2244
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0307 0.2598
Entamoeba histolytica hypothetical protein 0.0202 0.1012 0.8845
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.002 0.0051
Loa Loa (eye worm) hypothetical protein 0.0024 0.002 0.0051
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.0105 0.0203
Onchocerca volvulus 0.0029 0.0047 0.0601
Brugia malayi Eukaryotic aspartyl protease family protein 0.0105 0.0469 0.137
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0116 0.0228
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.002 0.0051
Loa Loa (eye worm) hypothetical protein 0.0286 0.1474 0.5649
Echinococcus multilocularis protein patched 0.0051 0.0171 0.0349
Toxoplasma gondii aspartyl protease ASP3 0.0105 0.0469 0.6588
Loa Loa (eye worm) hypothetical protein 0.0062 0.0235 0.0879
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.002 0.0013
Plasmodium falciparum plasmepsin II 0.0147 0.0705 1
Echinococcus granulosus microtubule associated protein 2 0.0833 0.4517 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.002 0.0051
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0045 0.0137 0.0372
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0621 0.3335 1
Brugia malayi aspartic protease BmAsp-1, identical 0.0105 0.0469 0.137
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.019 0.0943 0.8228
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0147 0.0705 1
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0045 0.0137 0.1093
Loa Loa (eye worm) hypothetical protein 0.0024 0.002 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0171 0.1393
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.002 0.0051
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0076 0.0307 0.0883
Entamoeba histolytica hypothetical protein 0.0041 0.0116 0.0908
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0047 0.0099
Plasmodium falciparum plasmepsin VI 0.0147 0.0705 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0068 0.0268 0.2249
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0068 0.0268 0.2249
Loa Loa (eye worm) hypothetical protein 0.0051 0.0171 0.0634
Schistosoma mansoni nuclear hormone receptor 0.0024 0.002 0.0006
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0076 0.0307 0.2598
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.002 0.0018
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0045 0.0137 0.1873
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0327 0.1706 0.3756
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0047 0.1121
Mycobacterium ulcerans hypothetical protein 0.0029 0.0047 0.0147
Schistosoma mansoni patched 1 0.0051 0.0171 0.0157
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0149 0.1194
Echinococcus granulosus FTZ F1 alpha 0.0024 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0024 0.002 0.0051
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0295 0.1073
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0105 0.0469 0.0456
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.002 0.0051
Brugia malayi CHE-14 protein 0.0051 0.0171 0.0474
Plasmodium falciparum plasmepsin VII 0.0105 0.0469 0.6624
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0295 0.0282
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0047 0.017
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.002 0.0006
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.002 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.002 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0085 0.2433
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0014 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0149 0.4596
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.002 0.0018
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.019 0.0943 0.8228
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0171 0.0349
Brugia malayi nuclear receptor NHR-88 0.0024 0.002 0.0018
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0149 0.4596
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0149 0.1194
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0045 0.0137 0.0274
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.002 0.0013
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0091 0.0684
Loa Loa (eye worm) hypothetical protein 0.0105 0.0469 0.178
Brugia malayi hypothetical protein 0.0286 0.1474 0.4396
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.002 0.0018
Echinococcus multilocularis tumor protein p63 0.0408 0.2155 0.4753
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.002 0.0018
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0047 0.017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0226 0.1143 0.3399
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0045 0.0137 0.1873
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0022 0.0264
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0149 0.4596
Schistosoma mansoni thyroid hormone receptor 0.0024 0.002 0.0006
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0047 0.0147
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0116 0.0228
Echinococcus granulosus expressed protein 0.0364 0.1909 0.4207
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.002 0.0006
Brugia malayi Pepsin A precursor 0.0105 0.0469 0.137
Loa Loa (eye worm) hypothetical protein 0.0105 0.0469 0.178
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0047 0.0147
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0105 0.0469 0.0456
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0149 0.4596
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0147 0.0705 0.2687
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0226 0.1143 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0047 0.0291
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0105 0.0469 0.0456
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0226 0.1143 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.002 0.0013
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0006 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.002 0.0018
Brugia malayi aspartic protease BmAsp-2, identical 0.0105 0.0469 0.137
Echinococcus granulosus dna polymerase kappa 0.0047 0.0149 0.0299
Schistosoma mansoni hypothetical protein 0.0059 0.0216 0.0203
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.002 0.0013
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0045 0.0137 0.1787
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0149 0.4596
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0832 0.1816
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0171 0.0634
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0155
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0548 0.4732
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0125 0.0112
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0219 0.0206
Loa Loa (eye worm) hypothetical protein 0.0024 0.002 0.0051
Mycobacterium tuberculosis Isocitrate lyase Icl (isocitrase) (isocitratase) 0.0515 0.2749 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0548 0.2085
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.002 0.0018
Brugia malayi hypothetical protein 0.0041 0.0116 0.0309
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.002 0.0013
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.002 0.0006
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0149 0.0518
Loa Loa (eye worm) hypothetical protein 0.0024 0.002 0.0051
Brugia malayi nuclear hormone receptor 0.0024 0.002 0.0018
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0105 0.0469 0.0456
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0104 0.0468 0.1367
Entamoeba histolytica hypothetical protein 0.0041 0.0116 0.0908
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0149 0.4596
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0226 0.1143 1
Schistosoma mansoni hypothetical protein 0.0049 0.0161 0.0147
Plasmodium falciparum plasmepsin IV 0.0147 0.0705 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0068 0.0268 0.2249
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0076 0.0307 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0149 0.4596
Brugia malayi hypothetical protein 0.0105 0.0469 0.137
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.0149 0.1194
Plasmodium falciparum plasmepsin V 0.0105 0.0469 0.6624
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0211 0.0594
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.002 0.0013
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0047 0.0147
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0091 0.0684
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0047 0.0147
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0047 0.1121
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0548 0.1186
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0045 0.0137 0.4208
Echinococcus multilocularis expressed protein 0.0364 0.1909 0.4207
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0202 0.1012 0.8845
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0295 0.0282
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.002 0.0018
Schistosoma mansoni hypothetical protein 0.0041 0.0116 0.0103
Schistosoma mansoni hypothetical protein 0.0058 0.0211 0.0198
Plasmodium vivax aspartyl protease, putative 0.0105 0.0469 0.6624
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0295 0.0624
Plasmodium falciparum plasmepsin I 0.0147 0.0705 1
Mycobacterium leprae Isocitrate lyase 0.0241 0.1229 0.4375
Loa Loa (eye worm) phosphatidylinositol 3 0.0304 0.1575 0.6038
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0045 0.0137 0.1093
Plasmodium vivax aspartyl proteinase, putative 0.0105 0.0469 0.6624
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0548 0.1609
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0105 0.0469 0.6588
Echinococcus granulosus transcription factor Dp 1 0.0044 0.013 0.0259
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0226 0.1143 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0155
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0045 0.0137 0.1093
Schistosoma mansoni survival motor neuron protein 0.0058 0.0211 0.0198
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.0149 0.1194
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.4517 0.451
Onchocerca volvulus 0.0058 0.0211 0.4264
Plasmodium vivax plasmepsin IV, putative 0.0147 0.0705 1
Mycobacterium tuberculosis Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) 0.0515 0.2749 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0014 0.5
Onchocerca volvulus 0.0105 0.0469 1
Schistosoma mansoni hypothetical protein 0.0049 0.0161 0.0147
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0034 0.0075 0.0764
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0166 0.0812 1
Brugia malayi ecdysteroid receptor 0.0024 0.002 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0149 0.4596
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.4517 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0058 0.0211 0.1746
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0216 0.1086 0.9498
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.002 0.0006
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0068 0.0268 0.0254
Entamoeba histolytica hypothetical protein 0.0041 0.0116 0.0908
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0024 0.0022 0.0078
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.002 0.0018
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0171 0.0349
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0116 0.0103
Echinococcus multilocularis geminin 0.0205 0.1024 0.2244
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0014 0.0105
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.002 0.0006
Loa Loa (eye worm) hypothetical protein 0.006 0.0219 0.082
Entamoeba histolytica hypothetical protein 0.0041 0.0116 0.0908
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0295 0.0624
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.002 0.0013
Brugia malayi polk-prov protein 0.0036 0.0085 0.0215
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0034 0.0077 0.027
Plasmodium vivax plasmepsin V, putative 0.0105 0.0469 0.6624
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.1474 0.3243
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0155
Brugia malayi hypothetical protein 0.0105 0.0469 0.137
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.002 0.0006
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0104 0.0468 0.1776
Schistosoma mansoni cathepsin D (A01 family) 0.0255 0.1306 0.1294
Loa Loa (eye worm) hypothetical protein 0.0024 0.002 0.0051
Schistosoma mansoni cathepsin D (A01 family) 0.0255 0.1306 0.1294
Onchocerca volvulus 0.006 0.0219 0.4447
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0327 0.1706 0.3756
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0105 0.0469 0.0456
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0832 0.1816
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0045 0.0137 0.1787
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0047 0.0147
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.002 0.0013
Schistosoma mansoni hypothetical protein 0.0049 0.0161 0.0147
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0047 0.0099
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0149 0.1194
Plasmodium falciparum plasmepsin X 0.0105 0.0469 0.6624
Giardia lamblia DINP protein human, muc B family 0.0024 0.0022 0.0097
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0105 0.0469 0.0456
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0047 0.0099
Mycobacterium tuberculosis Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) 0.0515 0.2749 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0307 0.2598
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0085 0.2433
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.0105 0.0381
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0081 0.0337 0.2865
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0068 0.0268 0.2249
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0295 0.1052
Loa Loa (eye worm) hypothetical protein 0.0122 0.0563 0.2141
Loa Loa (eye worm) hypothetical protein 0.0263 0.1347 0.5161
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.0105 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.002 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.002 0.0018
Echinococcus granulosus expressed conserved protein 0.0112 0.0508 0.1098
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0295 0.1052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.002 0.0051
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0147 0.0705 0.1534
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.002 0.0013
Schistosoma mansoni hypothetical protein 0.0049 0.0161 0.0147
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0105 0.0469 0.0456
Plasmodium falciparum plasmepsin III 0.0105 0.0469 0.6624
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0076 0.0307 0.0651
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0295 0.1052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.002 0.0051
Mycobacterium ulcerans isocitrate lyase Icl 0.0515 0.2749 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0149 0.4596
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0047 0.0147
Loa Loa (eye worm) aspartyl protease 6 0.0105 0.0469 0.178
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0068 0.0268 0.8655
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0548 0.1186
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0147 0.0705 0.6118
Loa Loa (eye worm) hypothetical protein 0.0489 0.2604 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0076 0.0307 0.0294
Loa Loa (eye worm) hypothetical protein 0.0131 0.0616 0.2348
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0047 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0149 0.4596
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0076 0.0307 0.0651
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0171 0.0349
Mycobacterium ulcerans isocitrate lyase AceAb 0.0515 0.2749 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0104 0.0468 0.1008
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.002 0.0018
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0558 0.0545
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.002 0.0013
Schistosoma mansoni hypothetical protein 0.0205 0.1024 0.1012
Plasmodium vivax aspartyl protease, putative 0.0105 0.0469 0.6624
Leishmania major phosphatidylinositol 3-kinase, putative 0.0045 0.0137 0.4208
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0295 0.9584
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0105 0.0469 0.0456
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0147 0.0705 0.1534
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0104 0.0468 0.1008
Echinococcus granulosus tumor protein p63 0.0408 0.2155 0.4753
Brugia malayi steroid hormone receptor 0.0024 0.002 0.0018
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.002 0.0018
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0014 0.0105
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0045 0.0137 0.1093
Leishmania major DNA polymerase kappa, putative 0.0024 0.0022 0.0264
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0295 0.4071
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0105 0.0469 0.178
Schistosoma mansoni coup transcription factor 0.0024 0.002 0.0006
Echinococcus multilocularis dna polymerase kappa 0.0047 0.0149 0.0299
Mycobacterium leprae PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) 0.0515 0.2749 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.002 0.0018
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0024 0.0022 0.0264
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.1474 0.3243
Echinococcus multilocularis expressed conserved protein 0.0112 0.0508 0.1098
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.0105 0.0203
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0226 0.1143 1
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.002 0.0013
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0045 0.0137 0.0124
Loa Loa (eye worm) hypothetical protein 0.0024 0.002 0.0051
Toxoplasma gondii aspartyl protease 0.0105 0.0469 0.6588
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0045 0.0137 0.1093
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0045 0.0137 0.1093
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0014 0.005
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0147 0.0705 0.2687
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0068 0.0268 0.2249
Echinococcus multilocularis Zinc finger, PHD finger 0.0045 0.0137 0.0274
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0045 0.0137 0.1093
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.002 0.0018
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0149 0.1194
Echinococcus multilocularis protein dispatched 1 0.0058 0.0211 0.0438
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.002 0.0006
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.002 0.0013
Loa Loa (eye worm) hypothetical protein 0.0024 0.002 0.0051
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.013 0.0259
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0327 0.1706 0.1694
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0014 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0149 0.4596
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0045 0.0137 0.0503
Onchocerca volvulus 0.0105 0.0469 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.0211 0.0787
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0307 1
Schistosoma mansoni hypothetical protein 0.0205 0.1024 0.1012
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0006 0.0024
Loa Loa (eye worm) hypothetical protein 0.0036 0.0085 0.0303
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0047 0.0291
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0045 0.0137 0.4208
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.002 0.0006
Plasmodium vivax aspartyl protease, putative 0.0105 0.0469 0.6624
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0226 0.1145 0.1133
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.002 0.0013
Plasmodium falciparum plasmepsin VIII, putative 0.0105 0.0469 0.6624
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0014 0.0028
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0226 0.1143 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.002 0.0018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0068 0.0268 0.0764
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0047 0.1121
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0045 0.0137 0.0274
Plasmodium falciparum plasmepsin IX 0.0105 0.0469 0.6624

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 60 uM Inhibition of human recombinant PTP1B ChEMBL. 17125223

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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