TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 369.418 | Formula: C19H23N5O3
H donors: 1 H acceptors: 3 LogP: 2.57 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1CNc1ncnc2c1ncn2C1CCCCO1)OC
InChi: 1S/C19H23N5O3/c1-25-14-6-5-7-15(26-2)13(14)10-20-18-17-19(22-11-21-18)24(12-23-17)16-8-3-4-9-27-16/h5-7,11-12,16H,3-4,8-10H2,1-2H3,(H,20,21,22)
InChiKey: GZAWIXXSUKWZDV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	beta-glucosidase, putative	0.0131	0.0174	0.0418
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0031	0.0031
Trichomonas vaginalis	glucosylceramidase, putative	0.1647	0.3789	1
Schistosoma mansoni	mannosidase alpha class 2a	0.0091	0.0078	0.0087
Onchocerca volvulus		0.0091	0.0078	0.0071
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0915	0.2043	0.5373
Schistosoma mansoni	mannosyl-oligosaccharide alpha-12-mannosidase	0.0096	0.009	0.0101
Schistosoma mansoni	beta-galactosidase	0.0514	0.1087	0.1212
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0977	0.219	0.2175
Loa Loa (eye worm)	beta-glucuronidase	0.0156	0.0233	0.0233
Onchocerca volvulus		0.0091	0.0078	0.0071
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0031	0.004
Echinococcus granulosus	non lysosomal glucosylceramidase	0.1031	0.2319	0.2305
Trichomonas vaginalis	glucosylceramidase, putative	0.1647	0.3789	1
Trichomonas vaginalis	glucosylceramidase, putative	0.1647	0.3789	1
Onchocerca volvulus	Ceramide glucosyltransferase homolog	0.1214	0.2756	0.409
Trichomonas vaginalis	conserved hypothetical protein	0.0377	0.0762	0.1977
Trichomonas vaginalis	mannosyl-oligosaccharide alpha-1,2-mannosidase, putative	0.0096	0.009	0.0198
Trichomonas vaginalis	conserved hypothetical protein	0.0128	0.0166	0.0399
Brugia malayi	Glycosyl hydrolases family 38 protein	0.0091	0.0078	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0701	0.1533	0.1533
Onchocerca volvulus	Trehalase homolog	0.0128	0.0166	0.0203
Trypanosoma cruzi	hypothetical protein, conserved	0.0977	0.219	1
Loa Loa (eye worm)	hypothetical protein	0.0096	0.009	0.009
Brugia malayi	Trehalase family protein	0.0128	0.0166	0.0147
Trichomonas vaginalis	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative	0.0096	0.009	0.0198
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.048	0.1005	0.1463
Schistosoma mansoni	phosphorylase B kinase alpha kpb1	0.0071	0.0031	0.0034
Trichomonas vaginalis	glucosylceramidase, putative	0.1139	0.2577	0.6789
Brugia malayi	Ceramide glucosyltransferase	0.1214	0.2756	0.2743
Brugia malayi	Trehalase family protein	0.0128	0.0166	0.0147
Brugia malayi	Glycosyl hydrolases family 38 protein	0.0091	0.0078	0.0059
Schistosoma mansoni	hypothetical protein	0.0162	0.0247	0.0276
Brugia malayi	hypothetical protein	0.0128	0.0166	0.0147
Schistosoma mansoni	lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1)	0.0091	0.0078	0.0087
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.1647	0.3789	0.3789
Loa Loa (eye worm)	trehalase	0.0128	0.0166	0.0166
Loa Loa (eye worm)	glycosyl hydrolase family 38 protein	0.0143	0.0203	0.0203
Loa Loa (eye worm)	alpha-L-fucosidase	0.0423	0.087	0.087
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0157	0.0236	0.5
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.048	0.1005	0.2623
Trichomonas vaginalis	mannosyl-oligosaccharide alpha-1,2-mannosidase, putative	0.0096	0.009	0.0198
Trichomonas vaginalis	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative	0.0096	0.009	0.0198
Schistosoma mansoni	hypothetical protein	0.0426	0.0878	0.0979
Brugia malayi	hypothetical protein	0.0071	0.0031	0.0012
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0977	0.219	1
Schistosoma mansoni	alpha-glucosidase	0.3818	0.8963	1
Loa Loa (eye worm)	TRE-2 protein	0.0128	0.0166	0.0166
Trichomonas vaginalis	alpha-glucosidase, putative	0.0977	0.219	0.5763
Echinococcus granulosus	lysosomal alpha glucosidase	0.4253	1	1
Brugia malayi	manba-prov protein	0.023	0.0411	0.0393
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0059	0.0059
Echinococcus multilocularis	dnaJ subfamily B	0.0426	0.0878	0.086
Loa Loa (eye worm)	glycosyl hydrolase family 2	0.0169	0.0264	0.0264
Echinococcus multilocularis	lysosomal alpha glucosidase	0.4253	1	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0977	0.219	0.5763
Brugia malayi	Trehalase family protein	0.0128	0.0166	0.0147
Mycobacterium ulcerans	alpha-L-fucosidase	0.0423	0.087	1
Echinococcus granulosus	endoplasmic reticulum mannosyl oligosaccharide	0.0096	0.009	0.0071
Echinococcus multilocularis	alpha mannosidase 2	0.0091	0.0078	0.0059
Trichomonas vaginalis	glucosylceramidase, putative	0.1139	0.2577	0.6789
Trichomonas vaginalis	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative	0.0096	0.009	0.0198
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0019	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0696	0.1521	0.1521
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0166	0.0166
Trichomonas vaginalis	mannosyl-oligosaccharide alpha-1,2-mannosidase, putative	0.0096	0.009	0.0198
Echinococcus multilocularis	lysosomal alpha mannosidase	0.0128	0.0166	0.0147
Onchocerca volvulus		0.0128	0.0166	0.0203
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0915	0.2043	0.9274
Trypanosoma brucei	lysosomal alpha-mannosidase precursor, putative	0.0128	0.0166	0.0311
Mycobacterium ulcerans	alpha-mannosidase	0.0143	0.0203	0.2052
Schistosoma mansoni	lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1)	0.0128	0.0166	0.0186
Brugia malayi	Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform 1	0.0096	0.009	0.0071
Onchocerca volvulus		0.0128	0.0166	0.0203
Echinococcus granulosus	lysosomal alpha mannosidase	0.0128	0.0166	0.0147
Brugia malayi	Glycosyl hydrolases family 38 protein	0.0143	0.0203	0.0184
Schistosoma mansoni	alpha glucosidase	0.0977	0.219	0.2444
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0019	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0031	0.0031
Schistosoma mansoni	beta-mannosidase	0.0127	0.0165	0.0184
Leishmania major	alpha glucosidase II subunit, putative	0.0977	0.219	1
Echinococcus granulosus	neutral alpha glucosidase AB	0.0977	0.219	0.2175
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0031	0.004
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.048	0.1005	0.416
Trichomonas vaginalis	alpha-glucosidase, putative	0.048	0.1005	0.2623
Schistosoma mansoni	ceramide glucosyltransferase	0.1214	0.2756	0.3076
Trichomonas vaginalis	beta-mannosidase, putative	0.0127	0.0165	0.0396
Trichomonas vaginalis	glucosylceramidase, putative	0.1081	0.2438	0.6421
Trichomonas vaginalis	glucosylceramidase, putative	0.1081	0.2438	0.6421
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0977	0.219	0.2175
Trichomonas vaginalis	glycoside hydrolases, putative	0.0131	0.0174	0.0418
Brugia malayi	Beta-glucuronidase precursor	0.0156	0.0233	0.0215
Echinococcus multilocularis	non lysosomal glucosylceramidase	0.1031	0.2319	0.2305
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0078	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0031	0.0031
Brugia malayi	Alpha-L-fucosidase family protein	0.0423	0.087	0.0852
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0019	0.0021
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0977	0.219	1
Echinococcus granulosus	ceramide glucosyltransferase	0.1214	0.2756	0.2743
Brugia malayi	Glycosyl hydrolases family 31 protein	0.048	0.1005	0.0988
Trichomonas vaginalis	glucosylceramidase, putative	0.1081	0.2438	0.6421
Echinococcus multilocularis	fucosidase, alpha L 1, tissue	0.0423	0.087	0.0852
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.0013	0.0015
Onchocerca volvulus	Glucosylceramidase homolog	0.1081	0.2438	0.3613
Onchocerca volvulus		0.0128	0.0166	0.0203
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.048	0.1005	0.4147
Echinococcus granulosus	bile acid beta glucosidase	0.1031	0.2319	0.2305
Schistosoma mansoni	phosphorylase B kinase beta kpbb	0.0071	0.0031	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0162	0.0162
Echinococcus multilocularis	lysosomal alpha glucosidase	0.4253	1	1
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0078	0.0078
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0977	0.219	0.219
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0019	0.0021
Echinococcus multilocularis	mannosyl oligosaccharide 1,2 alpha mannosidase	0.0096	0.009	0.0071
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0186	0.0304	0.0764
Echinococcus granulosus	phosphorylase b kinase regulatory	0.0071	0.0031	0.0012
Brugia malayi	Trehalase family protein	0.0128	0.0166	0.0147
Echinococcus multilocularis	phosphorylase b kinase regulatory	0.0071	0.0031	0.0012
Loa Loa (eye worm)	mannosidase	0.0096	0.009	0.009
Echinococcus granulosus	beta mannosidase	0.0074	0.0039	0.002
Loa Loa (eye worm)	hypothetical protein	0.0096	0.009	0.009
Trichomonas vaginalis	glucosylceramidase, putative	0.1081	0.2438	0.6421
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0031	0.0031
Trichomonas vaginalis	alpha-glucosidase, putative	0.048	0.1005	0.2623
Loa Loa (eye worm)	hypothetical protein	0.0514	0.1087	0.1087
Brugia malayi	lysosomal alpha-mannosidase	0.0091	0.0078	0.0059
Trichomonas vaginalis	glycoside hydrolase, putative	0.0475	0.0993	0.2591
Brugia malayi	hypothetical protein	0.0071	0.0031	0.0012
Loa Loa (eye worm)	manba-prov protein	0.0074	0.0039	0.0039
Echinococcus multilocularis	ceramide glucosyltransferase	0.1214	0.2756	0.2743
Trichomonas vaginalis	glucosylceramidase, putative	0.1081	0.2438	0.6421
Entamoeba histolytica	alpha-1,2-mannosidase, putative	0.0864	0.1921	0.8672
Echinococcus granulosus	phosphorylase b kinase regulatory	0.0071	0.0031	0.0012
Onchocerca volvulus		0.0128	0.0166	0.0203
Trichomonas vaginalis	trehalase, putative	0.0128	0.0166	0.0399
Echinococcus granulosus	dnaJ subfamily B	0.0426	0.0878	0.086
Echinococcus multilocularis	endoplasmic reticulum mannosyl oligosaccharide	0.0096	0.009	0.0071
Trichomonas vaginalis	alpha-glucosidase, putative	0.0977	0.219	0.5763
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0166	0.0166
Echinococcus granulosus	glycogen debranching enzyme	0.0126	0.0162	0.0143
Plasmodium vivax	hypothetical protein, conserved	0.0157	0.0236	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0977	0.219	1
Echinococcus granulosus	mannosyl oligosaccharide 12 alpha mannosidase	0.0096	0.009	0.0071
Echinococcus multilocularis	beta mannosidase	0.0074	0.0039	0.002
Schistosoma mansoni	hypothetical protein	0.0266	0.0496	0.0553
Trichomonas vaginalis	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative	0.0096	0.009	0.0198
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.1647	0.3789	0.3777
Loa Loa (eye worm)	ceramide glucosyltransferase	0.1214	0.2756	0.2756
Trichomonas vaginalis	alpha-glucosidase, putative	0.0977	0.219	0.5763
Brugia malayi	Amylo-alpha-1,6-glucosidase family protein	0.0126	0.0162	0.0143
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.4253	1	1
Trichomonas vaginalis	mannosyl-oligosaccharide alpha-1,2-mannosidase, putative	0.0096	0.009	0.0198
Trichomonas vaginalis	glucosylceramidase, putative	0.1081	0.2438	0.6421
Loa Loa (eye worm)	hypothetical protein	0.048	0.1005	0.1005
Trichomonas vaginalis	glycogen debranching enzyme, putative	0.0126	0.0162	0.0387
Brugia malayi	Glycosyl hydrolases family 2, sugar binding domain containing protein	0.0169	0.0264	0.0246
Trichomonas vaginalis	mannosyl-oligosaccharide alpha-1,2-mannosidase, putative	0.0096	0.009	0.0198
Trichomonas vaginalis	alpha-glucosidase, putative	0.048	0.1005	0.2623
Schistosoma mansoni	ceramide glucosyltransferase	0.1214	0.2756	0.3076
Trichomonas vaginalis	conserved hypothetical protein	0.0096	0.009	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0128	0.0166	0.0166
Onchocerca volvulus		0.0128	0.0166	0.0203
Schistosoma mansoni	bile acid beta-glucosidase-related	0.1031	0.2319	0.2588
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0088	0.0088
Onchocerca volvulus		0.2867	0.6695	1
Trichomonas vaginalis	mannosyl-oligosaccharide alpha-1,2-mannosidase, putative	0.0096	0.009	0.0198
Trichomonas vaginalis	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative	0.0096	0.009	0.0198
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0977	0.219	0.5763
Loa Loa (eye worm)	amylo-alpha-1,6-glucosidase	0.0061	0.0008	0.0008
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.048	0.1005	0.4147
Trichomonas vaginalis	beta-galactosidase, putative	0.0377	0.0762	0.1977
Trichomonas vaginalis	alpha-mannosidase, putative	0.0143	0.0203	0.0496
Trichomonas vaginalis	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative	0.0096	0.009	0.0198
Loa Loa (eye worm)	TAR-binding protein	0.0066	0.0019	0.0019
Loa Loa (eye worm)	TRE-1 protein	0.0128	0.0166	0.0166
Trypanosoma brucei	glucosidase, putative	0.0977	0.219	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0977	0.219	0.5763
Trichomonas vaginalis	glucosylceramidase, putative	0.1647	0.3789	1
Loa Loa (eye worm)	myosin heavy chain	0.0071	0.0031	0.0031
Brugia malayi	phosphorylase B kinase beta regulatory chain	0.0071	0.0031	0.0012
Echinococcus granulosus	beta galactosidase	0.0514	0.1087	0.107
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0061	0.0061
Schistosoma mansoni	alpha-l-fucosidase	0.0423	0.087	0.097
Echinococcus multilocularis	phosphorylase b kinase regulatory	0.0071	0.0031	0.0012
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0186	0.0304	0.0764
Trichomonas vaginalis	alpha-mannosidase 2c1, putative	0.0143	0.0203	0.0496
Trichomonas vaginalis	alpha-glucosidase, putative	0.0977	0.219	0.5763
Trichomonas vaginalis	glucosylceramidase, putative	0.1081	0.2438	0.6421
Trichomonas vaginalis	alpha-glucosidase, putative	0.048	0.1005	0.2623
Echinococcus granulosus	fucosidase alpha L 1 tissue	0.0423	0.087	0.0852
Loa Loa (eye worm)	trehalase	0.0128	0.0166	0.0166
Schistosoma mansoni	bile acid beta-glucosidase-related	0.1031	0.2319	0.2588
Brugia malayi	phosphorylase B kinase alpha regulatory chain	0.0071	0.0031	0.0012
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.048	0.1005	0.2623
Echinococcus multilocularis	bile acid beta glucosidase	0.1031	0.2319	0.2305
Mycobacterium tuberculosis	Possible conserved exported protein	0.0864	0.1921	1
Giardia lamblia	Ceramide glucosyltransferase	0.0551	0.1174	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.048	0.1005	0.2623
Schistosoma mansoni	hypothetical protein	0.0091	0.0078	0.0088
Trypanosoma brucei	glycosyl hydrolase-like protein	0.048	0.1005	0.4328
Entamoeba histolytica	beta-galactosidase, putative	0.0222	0.039	0.1126
Trichomonas vaginalis	glucosylceramidase, putative	0.1647	0.3789	1
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0019	0.0021
Loa Loa (eye worm)	trehalase	0.0128	0.0166	0.0166
Loa Loa (eye worm)	RNA binding protein	0.0066	0.0019	0.0019
Schistosoma mansoni	alpha-glucosidase	0.3818	0.8963	1
Echinococcus multilocularis	beta galactosidase	0.0514	0.1087	0.107
Echinococcus multilocularis	glycogen debranching enzyme	0.0126	0.0162	0.0143
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0066	0.0019	0.0019
Trichomonas vaginalis	alpha-mannosidase 2c1, putative	0.008	0.0052	0.0095
Trichomonas vaginalis	alpha-glucosidase, putative	0.048	0.1005	0.2623
Echinococcus multilocularis	transfer RNA-Trp	0.0096	0.009	0.0071
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0977	0.219	0.5763
Trichomonas vaginalis	alpha-mannosidase 2c1, putative	0.0085	0.0065	0.013
Trichomonas vaginalis	conserved hypothetical protein	0.0071	0.0031	0.004
Trichomonas vaginalis	endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative	0.0096	0.009	0.0198
Trichomonas vaginalis	glycogen debranching enzyme, putative	0.0126	0.0162	0.0387
Trichomonas vaginalis	glucosylceramidase, putative	0.1647	0.3789	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (ADMET)	= 10.3 umol/L	Cytotoxicity against human K562 cells after 72 hrs by Calcein AM assay	ChEMBL.	19232496
IC50 (ADMET)	> 100 umol/L	Cytotoxicity against human BJ cells after 72 hrs by MTT assay	ChEMBL.	19232496
IC50 (ADMET)	> 100 umol/L	Cytotoxicity against human MCF7 cells after 72 hrs by Calcein AM assay	ChEMBL.	19232496

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	19232496

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL448877

Bibliographic References

No literature references available for this target.

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Detailed information for compound 955314