TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 562.7 | Formula: C32H42N4O5
H donors: 4 H acceptors: 5 LogP: 5.15 Rotable bonds: 18
Rule of 5 violations (Lipinski): 2
SMILES: CCCC[C@@H](C(=O)C(=O)NC1CCCCC1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)c1ccccc1)Cc1ccccc1)C
InChi: 1S/C32H42N4O5/c1-3-4-20-26(28(37)32(41)34-25-18-12-7-13-19-25)35-29(38)22(2)33-31(40)27(21-23-14-8-5-9-15-23)36-30(39)24-16-10-6-11-17-24/h5-6,8-11,14-17,22,25-27H,3-4,7,12-13,18-21H2,1-2H3,(H,33,40)(H,34,41)(H,35,38)(H,36,39)/t22-,26-,27-/m0/s1
InChiKey: HTJKIAGROZBWBD-CAVYSCNFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Dermatophagoides pteronyssinus	Peptidase 1	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Papain family cysteine protease containing protein	Peptidase 1	320 aa	311 aa	25.7 %
Trypanosoma cruzi	cysteine proteinase, putative	Peptidase 1	320 aa	330 aa	27.6 %
Theileria parva	cysteine proteinase, putative	Peptidase 1	320 aa	288 aa	22.2 %
Onchocerca volvulus	Cathepsin B-like cysteine proteinase 6 homolog	Peptidase 1	320 aa	290 aa	23.4 %
Entamoeba histolytica	cysteine protease, putative	Peptidase 1	320 aa	339 aa	20.6 %
Leishmania donovani	cysteine peptidase C (CPC)	Peptidase 1	320 aa	335 aa	22.4 %
Onchocerca volvulus	Cathepsin L homolog	Peptidase 1	320 aa	266 aa	30.8 %
Giardia lamblia	Cathepsin L-like protease	Peptidase 1	320 aa	287 aa	25.8 %
Echinococcus granulosus	cathepsin L	Peptidase 1	320 aa	284 aa	27.8 %
Dictyostelium discoideum	hypothetical protein	Peptidase 1	320 aa	332 aa	25.9 %
Onchocerca volvulus		Peptidase 1	320 aa	310 aa	22.6 %
Trichomonas vaginalis	ankyrin repeat-rich membrane-spanning protein, putative	Peptidase 1	320 aa	304 aa	19.7 %
Echinococcus granulosus	cysteine protease	Peptidase 1	320 aa	318 aa	28.6 %
Dictyostelium discoideum	cathepsin L-like proteinase	Peptidase 1	320 aa	295 aa	30.5 %
Plasmodium berghei	berghepain-1	Peptidase 1	320 aa	330 aa	26.1 %
Echinococcus multilocularis	cathepsin L	Peptidase 1	320 aa	332 aa	26.5 %
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Peptidase 1	320 aa	275 aa	23.6 %
Trypanosoma cruzi	cysteine protease, putative	Peptidase 1	320 aa	304 aa	28.6 %
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Peptidase 1	320 aa	335 aa	22.4 %
Drosophila melanogaster	Cathepsin B1	Peptidase 1	320 aa	280 aa	25.0 %
Echinococcus granulosus	cathepsin L cysteine protease	Peptidase 1	320 aa	322 aa	28.3 %
Plasmodium vivax	vivapain-3	Peptidase 1	320 aa	330 aa	27.3 %
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Peptidase 1	320 aa	273 aa	23.1 %
Schistosoma japonicum	ko:K01365 cathepsin L [EC3.4.22.15], putative	Peptidase 1	320 aa	315 aa	26.0 %
Plasmodium vivax	unspecified product	Peptidase 1	320 aa	337 aa	25.5 %
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	Peptidase 1	320 aa	262 aa	30.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	Peptidase 1	320 aa	337 aa	25.2 %
Onchocerca volvulus		Peptidase 1	320 aa	268 aa	34.0 %
Theileria parva	cysteine proteinase, putative	Peptidase 1	320 aa	310 aa	25.8 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Entamoeba histolytica	cysteine protease, putative	Peptidase 1	320 aa	319 aa	25.4 %
Giardia lamblia	Cathepsin B precursor	Peptidase 1	320 aa	267 aa	26.2 %
Entamoeba histolytica	cysteine protease, putative	Peptidase 1	320 aa	358 aa	22.1 %
Entamoeba histolytica	cysteine protease, putative	Peptidase 1	320 aa	339 aa	20.6 %
Giardia lamblia	Cathepsin L precursor	Peptidase 1	320 aa	273 aa	26.4 %
Giardia lamblia	Cathepsin L precursor	Peptidase 1	320 aa	276 aa	22.1 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Peptidase 1	320 aa	316 aa	30.4 %
Entamoeba histolytica	cysteine protease, putative	Peptidase 1	320 aa	339 aa	20.6 %
Entamoeba histolytica	cysteine protease, putative	Peptidase 1	320 aa	342 aa	24.3 %
Plasmodium knowlesi	knowpain-1	Peptidase 1	320 aa	343 aa	25.7 %
Giardia lamblia	Cathepsin L precursor	Peptidase 1	320 aa	369 aa	22.2 %
Drosophila melanogaster	CG6347 gene product from transcript CG6347-RA	Peptidase 1	320 aa	325 aa	28.0 %
Giardia lamblia	Dipeptidyl-peptidase I precursor	Peptidase 1	320 aa	264 aa	24.2 %
Entamoeba histolytica	cysteine protease, putative	Peptidase 1	320 aa	357 aa	24.9 %
Plasmodium yoelii	cysteine proteinase precursor	Peptidase 1	320 aa	330 aa	26.7 %
Plasmodium vivax	vivapain-1	Peptidase 1	320 aa	337 aa	24.6 %
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Peptidase 1	320 aa	316 aa	30.4 %
Giardia lamblia	Dipeptidyl-peptidase I precursor	Peptidase 1	320 aa	281 aa	23.1 %
Onchocerca volvulus		Peptidase 1	320 aa	365 aa	26.3 %
Trypanosoma cruzi	cysteine proteinase, putative	Peptidase 1	320 aa	306 aa	29.7 %
Giardia lamblia	Cathepsin L precursor	Peptidase 1	320 aa	275 aa	23.6 %
Dictyostelium discoideum	hypothetical protein	Peptidase 1	320 aa	264 aa	25.8 %
Babesia bovis	cysteine protease 2	Peptidase 1	320 aa	305 aa	27.2 %
Onchocerca volvulus	Protein MCM10 homolog	Peptidase 1	320 aa	314 aa	26.4 %
Neospora caninum	cathepsin C2 (TgCPC2), putative	Peptidase 1	320 aa	261 aa	24.5 %
Entamoeba histolytica	cysteine protease, putative	Peptidase 1	320 aa	282 aa	23.4 %
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Peptidase 1	320 aa	337 aa	22.8 %
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Peptidase 1	320 aa	261 aa	25.3 %
Theileria parva	cysteine proteinase, putative	Peptidase 1	320 aa	309 aa	29.8 %
Schistosoma japonicum	ko:K01275 cathepsin C [EC3.4.14.1], putative	Peptidase 1	320 aa	262 aa	28.6 %
Echinococcus granulosus	cathepsin L	Peptidase 1	320 aa	354 aa	26.3 %
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Peptidase 1	320 aa	334 aa	23.4 %
Echinococcus multilocularis	cathepsin L	Peptidase 1	320 aa	358 aa	27.1 %
Entamoeba histolytica	cysteine protease, putative	Peptidase 1	320 aa	339 aa	20.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0052	0.2238	0.2238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.1375	0.4802
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0025	0.0463	0.1617
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0062	0.2864	1
Giardia lamblia	Cathepsin B precursor	0.0062	0.2864	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0929	0.3242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.2238	0.7814
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0032	0.0929	0.0929
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.0929	0.0929
Schistosoma mansoni	hypothetical protein	0.0042	0.1567	0.1567
Entamoeba histolytica	hypothetical protein	0.0042	0.1567	0.4872
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0929	0.3242
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0929	0.3242
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0173	1	1
Onchocerca volvulus		0.0032	0.0929	0.5
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0052	0.2238	0.2238
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0929	0.3242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.1549	0.5409
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.1375	0.4802
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0883	0.3082
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.1549	0.5409
Brugia malayi	cathepsin L-like precursor	0.0032	0.0929	0.0929
Plasmodium vivax	vivapain-2	0.0032	0.0929	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.1375	0.4802
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0929	0.3242
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0039	0.1375	0.2308
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0929	0.0929
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0929	0.3242
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0929	0.3242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.1549	0.5409
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0052	0.2238	0.7814
Brugia malayi	hypothetical protein	0.0042	0.1567	0.1567
Leishmania major	cysteine peptidase A (CPA)	0.0032	0.0929	0.3242
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.0929	0.0929
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0062	0.2864	0.2864
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.1375	0.4802
Echinococcus granulosus	cathepsin b	0.0173	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.1549	0.5409
Onchocerca volvulus		0.0032	0.0929	0.5
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0929	0.0929
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0052	0.2238	0.2238
Onchocerca volvulus		0.0032	0.0929	0.5
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0173	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0032	0.0929	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.1746	0.6095
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0929	0.0929
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0022	0.0269	0.094
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.0929	0.0929
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0929	0.3242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0689	0.2406
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.1549	0.5409
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0032	0.0929	0.5
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0052	0.2238	0.7814
Onchocerca volvulus		0.0032	0.0929	0.5
Loa Loa (eye worm)	cysteine protease	0.0032	0.0929	0.0929
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0686	0.2396
Echinococcus granulosus	cathepsin b	0.0173	1	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0052	0.2238	1
Echinococcus multilocularis	cathepsin b	0.0173	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0929	0.3242
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0929	0.0929
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0929	0.0929
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0929	0.0929
Echinococcus granulosus	cathepsin l1	0.0032	0.0929	0.0929
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0686	0.2396
Leishmania major	cathepsin L-like protease	0.0032	0.0929	0.3242
Loa Loa (eye worm)	phosphatidylinositol 3	0.0052	0.2238	0.2238
Toxoplasma gondii	cathepsin B	0.0062	0.2864	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0062	0.2864	0.2864
Entamoeba histolytica	hypothetical protein	0.0042	0.1567	0.4872
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.0929	0.0929
Leishmania major	cathepsin L-like protease	0.0032	0.0929	0.3242
Plasmodium vivax	vivapain-2	0.0032	0.0929	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.1375	0.4802
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0032	0.0929	0.0929
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0929	0.3242
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0929	0.3242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0689	0.2406
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.2238	0.7814
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.0929	0.3242
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0929	0.3242
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0062	0.2864	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0929	0.3242
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0929	0.0929
Trypanosoma cruzi	target of rapamycin kinase 3	0.0042	0.1552	0.1552
Leishmania major	cathepsin L-like protease	0.0032	0.0929	0.3242
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0929	0.0929
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0686	0.2396
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0929	0.0929
Leishmania major	cathepsin L-like protease	0.0032	0.0929	0.3242
Onchocerca volvulus		0.0032	0.0929	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.1375	0.4802
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0929	0.3242
Onchocerca volvulus		0.0032	0.0929	0.5
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0032	0.0929	0.0929
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0929	0.3242
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0929	0.3242
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0929	0.0929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0929	0.3242
Trypanosoma cruzi	cruzipain precursor, putative	0.0032	0.0929	0.0929
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0929	0.3242
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0929	0.0929
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.0929	0.5
Leishmania major	cathepsin L-like protease	0.0032	0.0929	0.3242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0883	0.3082
Giardia lamblia	Cathepsin B precursor	0.0062	0.2864	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0032	0.0929	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.0929	0.3242
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0052	0.2238	0.7814
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0032	0.0929	0.0929
Onchocerca volvulus		0.0032	0.0929	0.5
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.0929	0.0929
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0032	0.0929	0.0929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0929	0.3242
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.1567	0.1567
Leishmania major	cathepsin L-like protease	0.0032	0.0929	0.3242
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0929	0.3242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0689	0.2406
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.0929	0.0929
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0929	0.0929
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0689	0.2406
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0042	0.1552	0.5418
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0032	0.0929	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0052	0.2238	0.7814
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0929	0.3242
Entamoeba histolytica	hypothetical protein	0.0042	0.1567	0.4872
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0929	0.3242
Echinococcus multilocularis	cathepsin b	0.0173	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0929	0.3242
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0052	0.2238	1
Echinococcus multilocularis	cysteine protease	0.0032	0.0929	0.0929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0929	0.3242
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0929	0.0929
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.113	0.3944
Echinococcus granulosus	cathepsin l1	0.0032	0.0929	0.0929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0929	0.3242
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0032	0.0929	0.0929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0929	0.3242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0883	0.3082
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0173	1	1
Onchocerca volvulus		0.0032	0.0929	0.5
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0929	0.0929
Echinococcus multilocularis	cysteine protease	0.0032	0.0929	0.0929
Loa Loa (eye worm)	cathepsin B	0.0062	0.2864	0.2864
Leishmania major	cathepsin L-like protease	0.0032	0.0929	0.3242
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0929	0.3242
Loa Loa (eye worm)	hypothetical protein	0.0173	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0929	0.3242
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0929	0.3242
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0052	0.2238	0.7814
Brugia malayi	Cathepsin L-like precursor	0.0032	0.0929	0.0929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0929	0.3242
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.0929	0.0929
Loa Loa (eye worm)	ctsf protein	0.0032	0.0929	0.0929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0929	0.3242
Giardia lamblia	Cathepsin B precursor	0.0062	0.2864	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.0929	0.3242
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0929	0.3242
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0929	0.3242
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.0929	0.0929
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.1375	0.4802
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.1567	0.1567
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0052	0.2238	0.2238
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0052	0.2238	0.2238
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.0929	0.3242
Entamoeba histolytica	hypothetical protein	0.0042	0.1567	0.4872
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0052	0.2238	0.2238
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0863	0.3013
Loa Loa (eye worm)	fibroinase	0.0032	0.0929	0.0929
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.1057	0.369
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0173	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0173	1	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0929	0.0929
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.0929	0.5
Leishmania major	cathepsin L-like protease	0.0032	0.0929	0.3242
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0929	0.3242
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.1567	0.1567
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0042	0.1552	0.5418
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0062	0.2864	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0863	0.3013

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 8 nM	Inhibition of house dust mite Derp-1 after 20 mins	ChEMBL.	25365789
IC50 (binding)	= 16 nM	Inhibition of cathepsin B (unknown origin)	ChEMBL.	25365789
IC50 (binding)	= 17 nM	Reversible inhibition of house dust mite Derp-1	ChEMBL.	25365789
IC50 (binding)	= 17 nM	Inhibition of human liver cathepsin B using ABz-Gly-Ile-Val-Arg-Ala-Lys-DNP-OH as substrate after 10 mins by fluorescence assay	ChEMBL.	25365789

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3359772

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 956959