Detailed information for compound 957276

Basic information

Technical information
  • TDR Targets ID: 957276
  • Name: 4-(2-ethoxyphenoxy)-2-(trifluoromethyl)benzon itrile
  • MW: 307.267 | Formula: C16H12F3NO2
  • H donors: 0 H acceptors: 1 LogP: 4.39 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1Oc1ccc(c(c1)C(F)(F)F)C#N
  • InChi: 1S/C16H12F3NO2/c1-2-21-14-5-3-4-6-15(14)22-12-8-7-11(10-20)13(9-12)16(17,18)19/h3-9H,2H2,1H3
  • InChiKey: CQLBTXZQYBMHPR-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens androgen receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0316 0.0394
Loa Loa (eye worm) hypothetical protein 0.0056 0.0294 0.0294
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0294 0.0364
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0115 0.0748 0.1018
Plasmodium vivax phosphodiesterase gamma, putative 0.0056 0.0294 0.2837
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0294 0.04
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0294 0.04
Trypanosoma brucei Eukaryotic translation initiation factor 4E-2 0.0115 0.0748 0.0985
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0143 0.0968 0.1317
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0115 0.0748 0.1018
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0022 0.0027 0.0037
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1651 0.2246
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0962 0.7351 1
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0115 0.0748 0.0985
Loa Loa (eye worm) hypothetical protein 0.0056 0.0294 0.0294
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0294 0.0364
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0143 0.0968 0.0968
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0316 0.043
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0095 0.0592 0.0771
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0316 0.5112
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0294 0.0364
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0294 0.3701
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0056 0.0294 0.04
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Echinococcus multilocularis uridine 5' monophosphate synthase 0.0022 0.0027 0.0037
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Treponema pallidum hypothetical protein 0.0022 0.0027 0.5
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0056 0.0294 0.04
Trypanosoma cruzi Eukaryotic translation initiation factor 4E type 5, putative 0.0115 0.0748 0.0985
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0294 0.0364
Giardia lamblia Hypothetical protein 0.0115 0.0748 1
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0022 0.0027 0.0037
Loa Loa (eye worm) orotate phosphoribosyltransferase 0.0022 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0748 0.1018
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0962 0.7351 1
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0962 0.7351 1
Brugia malayi Adenine phosphoribosyltransferase 0.0022 0.0027 0.0027
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0143 0.0968 0.1285
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0056 0.0294 0.04
Entamoeba histolytica hypothetical protein 0.0115 0.0748 0.1018
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0962 0.7351 1
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.0294 0.0364
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0095 0.0592 0.0771
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0115 0.0748 0.1018
Onchocerca volvulus 0.0047 0.0221 0.2688
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0056 0.0294 0.04
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0143 0.0968 0.1317
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0115 0.0748 0.1018
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0095 0.0592 0.0805
Brugia malayi GTP-binding protein 0.0136 0.0914 0.0914
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0115 0.0748 0.0985
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0095 0.0592 0.0771
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0056 0.0294 0.0364
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0056 0.0294 0.04
Leishmania major eukaryotic translation initiation factor 4e, putative 0.0115 0.0748 0.0985
Loa Loa (eye worm) translation initiation factor 4E 0.0962 0.7351 0.7351
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0294 0.04
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0095 0.0592 0.0771
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0095 0.0592 0.0805
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0115 0.0748 0.1018
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0115 0.0748 0.1018
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0962 0.7351 1
Onchocerca volvulus 0.0095 0.0592 0.7833
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0095 0.0592 0.0805
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0115 0.0748 0.1018
Plasmodium falciparum eukaryotic translation initiation factor 4E 0.0115 0.0748 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0294 0.04
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0294 0.0364
Leishmania major eukaryotic translation initiation factor-like 0.0962 0.7351 1
Leishmania major xanthine phosphoribosyltransferase 0.0095 0.0592 0.0771
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0294 0.04
Mycobacterium tuberculosis Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor 0.0072 0.0419 0.9971
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-3 0.0115 0.0748 0.0985
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0294 0.0364
Leishmania major cAMP-specific phosphodiesterase, putative 0.0272 0.1973 0.2656
Leishmania major hypoxanthine-guanine phosphoribosyltransferase 0.0095 0.0592 0.0771
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0115 0.0748 0.1018
Echinococcus granulosus ras gtpase 0.0136 0.0914 0.1243
Echinococcus granulosus adenine phosphoribosyltransferase 0.0022 0.0027 0.0037
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0294 0.0364
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0294 0.2837
Mycobacterium tuberculosis Conserved hypothetical protein 0.0073 0.042 1
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0095 0.0592 0.0805
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0294 0.04
Toxoplasma gondii hypothetical protein 0.0115 0.0748 0.0985
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0095 0.0592 0.0771
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0294 0.04
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0294 0.0364
Schistosoma mansoni uracil phosphoribosyltransferase 0.0022 0.0027 0.0037
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Plasmodium falciparum phosphodiesterase delta, putative 0.0056 0.0294 0.3701
Trypanosoma brucei Eukaryotic translation initiation factor 4E-4 0.0115 0.0748 0.0985
Wolbachia endosymbiont of Brugia malayi amidophosphoribosyltransferase 0.0022 0.0027 0.5
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0115 0.0748 0.1018
Leishmania major eukaryotic translation initiation factor-like protein 0.0962 0.7351 1
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase, putative 0.0095 0.0592 0.6003
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0294 0.04
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0056 0.0294 0.0364
Echinococcus multilocularis expressed protein 0.0364 0.2691 0.3661
Loa Loa (eye worm) eukaryotic translation initiation factor 4E-1 0.0115 0.0748 0.0748
Treponema pallidum adenine phosphoribosyltransferase 0.0022 0.0027 0.5
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0115 0.0748 0.0985
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0272 0.1973 0.2656
Wolbachia endosymbiont of Brugia malayi orotate phosphoribosyltransferase 0.0022 0.0027 0.5
Loa Loa (eye worm) hypothetical protein 0.023 0.1651 0.1651
Trypanosoma cruzi eukaryotic translation initiation factor 4E (eIF4E) interacting protein, putative 0.0115 0.0748 0.0985
Schistosoma mansoni cell polarity protein 0.0136 0.0914 0.1243
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0294 0.0364
Leishmania major hypothetical protein, conserved 0.0115 0.0748 0.0985
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0962 0.7351 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0316 0.7342
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0294 0.0364
Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase 0.0095 0.0592 0.7833
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0316 0.0394
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0056 0.0294 0.04
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0294 0.04
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0294 0.0364
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0143 0.0968 0.1317
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0056 0.0294 0.04
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0056 0.0294 0.0294
Loa Loa (eye worm) hypothetical protein 0.1245 0.956 0.956
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0143 0.0968 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0316 0.5112
Trichomonas vaginalis ribose-phosphate pyrophosphokinase, putative 0.0022 0.0027 0.0037
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0294 0.3701
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0294 0.0364
Plasmodium falciparum eukaryotic translation initiation factor 4E, putative 0.0115 0.0748 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0962 0.7351 1
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0962 0.7351 1
Loa Loa (eye worm) GTP-binding protein 0.0136 0.0914 0.0914
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0294 0.04
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0115 0.0748 0.1018
Onchocerca volvulus Putative eukaryotic translation initiation factor 4e 0.0115 0.0748 1
Brugia malayi Phosphoribosyl transferase domain containing protein 0.0095 0.0592 0.0592
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Entamoeba histolytica eukaryotic initiation factor 4E, putative 0.0115 0.0748 0.1018
Leishmania major eukaryotic translation initiation factor, putative 0.0115 0.0748 0.0985
Trypanosoma brucei Eukaryotic translation initiation factor 4E type 5 0.0115 0.0748 0.0985
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0962 0.7351 1
Brugia malayi hypothetical protein 0.023 0.1651 0.1651
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0294 0.04
Plasmodium vivax hypothetical protein, conserved 0.0115 0.0748 0.7664
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0294 0.04
Loa Loa (eye worm) hypothetical protein 0.0056 0.0294 0.0294
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0056 0.0294 0.04
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0294 0.0364
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0143 0.0968 0.1317
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0056 0.0294 0.04
Entamoeba histolytica translation initiation factor 4e, putative 0.0115 0.0748 0.1018
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0056 0.0294 0.04
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.0968 0.1285
Trichomonas vaginalis Ribose-phosphate pyrophosphokinase, putative 0.0022 0.0027 0.0037
Mycobacterium leprae conserved hypothetical protein 0.0073 0.042 1
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0962 0.7351 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0115 0.0748 0.1018
Mycobacterium ulcerans hypoxanthine-guanine phosphoribosyltransferase Hpt 0.0095 0.0592 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Giardia lamblia Guanine phosphoribosyltransferase 0.0095 0.0592 0.7833
Mycobacterium leprae Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho 0.0072 0.0419 0.9971
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0143 0.0968 0.1317
Giardia lamblia hypothetical protein 0.0115 0.0748 1
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0294 0.0364
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0294 0.04
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0294 0.0364
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0115 0.0748 0.1018
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0294 0.04
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0294 0.04
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0294 0.0364
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-4 0.0115 0.0748 0.0985
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0056 0.0294 0.0364
Loa Loa (eye worm) adenine phosphoribosyltransferase 0.0022 0.0027 0.0027
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0294 0.04
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0316 0.043
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0294 0.04
Brugia malayi GTP-binding protein, identical 0.0136 0.0914 0.0914
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0056 0.0294 0.04
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0294 0.0364
Entamoeba histolytica hypothetical protein 0.0115 0.0748 0.1018
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0294 0.04
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0294 0.0364
Treponema pallidum phosphoribosylpyrophosphate synthetase 0.0022 0.0027 0.5
Echinococcus multilocularis adenine phosphoribosyltransferase 0.0022 0.0027 0.0037
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0115 0.0748 0.0985
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0962 0.7351 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0316 0.043
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0115 0.0748 0.1018
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0748 0.1018
Giardia lamblia Hypothetical protein 0.0056 0.0294 0.3701
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0962 0.7351 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0056 0.0294 0.04
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0294 0.04
Schistosoma mansoni hypothetical protein 0.0047 0.0221 0.03
Echinococcus granulosus eukaryotic translation initiation factor 4E type 0.0115 0.0748 0.1018
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0056 0.0294 0.04
Leishmania major hypothetical protein, conserved 0.0115 0.0748 0.0985
Loa Loa (eye worm) PDE1B protein 0.0143 0.0968 0.0968
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0115 0.0748 0.1018
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0294 0.0364
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0115 0.0748 0.1018
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1651 0.2246
Giardia lamblia hypothetical protein 0.0056 0.0294 0.3701
Echinococcus granulosus expressed protein 0.0364 0.2691 0.3661
Trichomonas vaginalis hypothetical protein 0.0115 0.0748 0.1018
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0056 0.0294 0.04
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Brugia malayi translation initiation factor 4E 0.0962 0.7351 0.7351
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0056 0.0294 0.3701
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0022 0.0027 0.0037
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0294 0.3701
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0143 0.0968 0.1285
Echinococcus multilocularis ras gtpase 0.0136 0.0914 0.1243
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0294 0.04
Leishmania major hypothetical protein, conserved 0.0056 0.0294 0.0364
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0115 0.0748 0.1018
Trypanosoma brucei Eukaryotic translation initiation factor 4E-3 0.0115 0.0748 0.0985
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT 0.0095 0.0592 0.0771
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0294 0.04
Echinococcus granulosus uridine 5' monophosphate synthase 0.0022 0.0027 0.0037
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0056 0.0294 0.0294
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0022 0.0027 0.0037
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0056 0.0294 0.0364
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0056 0.0294 0.2837
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0294 0.0294
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0962 0.7351 1
Leishmania major hypothetical protein, conserved 0.0056 0.0294 0.0364
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0056 0.0294 0.04
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0294 0.0364
Schistosoma mansoni orotidine 5'-phosphate decarboxylase 0.0022 0.0027 0.0037
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0221 0.0221
Mycobacterium tuberculosis Conserved hypothetical protein 0.0073 0.042 1
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0095 0.0592 0.0771
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0294 0.0364
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Plasmodium vivax translation initiation factor 4E, putative 0.0115 0.0748 0.7664
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0056 0.0294 0.0294
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0316 0.5112
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0071 0.0409 0.0556
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0095 0.0592 0.0805
Schistosoma mansoni survival motor neuron protein 0.0047 0.0221 0.03
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0294 0.0364
Giardia lamblia Hypothetical protein 0.0115 0.0748 1
Loa Loa (eye worm) hypothetical protein 0.1301 1 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0316 0.043
Brugia malayi orotate phosphoribosyltransferase family protein 0.0022 0.0027 0.0027
Loa Loa (eye worm) eukaryotic translation initiation factor 4E type 3 0.0115 0.0748 0.0748
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0294 0.0364
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0272 0.1973 0.2656
Plasmodium falciparum phosphodiesterase gamma, putative 0.0056 0.0294 0.3701
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0056 0.0294 0.04
Schistosoma mansoni cell polarity protein 0.0136 0.0914 0.1243
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0143 0.0968 0.1285
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0962 0.7351 1
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0748 0.1018
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0143 0.0968 0.1285
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0294 0.04
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0056 0.0294 0.04
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0056 0.0294 0.04
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0294 0.0364
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0294 0.0364
Brugia malayi Eukaryotic translation initiation factor 4E type 3, putative 0.0115 0.0748 0.0748
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0143 0.0968 0.1285
Trichomonas vaginalis hypoxanthine-guanine phosphoribosyltransferase, putative 0.0095 0.0592 0.0805
Trichomonas vaginalis eukaryotic translation initiation factor 4E type, putative 0.0115 0.0748 0.1018
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0056 0.0294 0.0294
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0056 0.0294 0.04
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0056 0.0294 0.04
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0056 0.0294 0.0364
Giardia lamblia Translation elongation factor 0.0115 0.0748 1
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase, putative 0.0095 0.0592 0.0771
Mycobacterium leprae conserved hypothetical protein 0.0073 0.042 1
Trypanosoma cruzi hypothetical protein, conserved 0.0056 0.0294 0.0364
Brugia malayi eukaryotic translation initiation factor 4E-1 0.0115 0.0748 0.0748
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0095 0.0592 0.0805
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0056 0.0294 0.3701

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 47 nM Antagonist activity at human androgen receptor expressed in human MDA-MB-231 cells assessed as inhibition of DHT-induced response ChEMBL. 19286380
IC50 (binding) = 120 nM Displacement of [3H]DHT from human cloned androgen receptor expressed in insect Sf9 cell system ChEMBL. 19286380

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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