Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Type-1A angiotensin II receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ATP synthase lipid-binding protein-like protein | 0.0129 | 0.4047 | 0.5858 |
Onchocerca volvulus | 0.0113 | 0.3438 | 1 | |
Leishmania major | ATPase subunit 9, putative | 0.0129 | 0.4047 | 0.933 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0141 | 0.4532 | 0.4532 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.007 | 0.1804 | 0.1804 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0043 | 0.0758 | 0.0758 |
Brugia malayi | jmjC domain containing protein | 0.007 | 0.1804 | 0.1804 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0043 | 0.0758 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.139 | 0.139 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0135 | 0.4283 | 0.4283 |
Brugia malayi | MH2 domain containing protein | 0.0143 | 0.4598 | 0.4598 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0043 | 0.0758 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.0335 | 0.0335 |
Brugia malayi | ATP synthase lipid-binding protein, mitochondrial precursor | 0.0129 | 0.4047 | 0.4047 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0312 | 0.0312 |
Echinococcus multilocularis | lamin dm0 | 0.0032 | 0.0335 | 0.0335 |
Mycobacterium ulcerans | F0F1 ATP synthase subunit C | 0.0129 | 0.4047 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0195 | 0.6607 | 0.6607 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0141 | 0.4532 | 0.4532 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0195 | 0.6607 | 0.6607 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0043 | 0.0758 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.1892 | 0.2738 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0043 | 0.0758 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.0335 | 0.0335 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.1316 | 0.1904 |
Trypanosoma brucei | Mitochondrial ATP synthase subunit c-1 | 0.0129 | 0.4047 | 1 |
Leishmania major | ATPase subunit 9, putative | 0.0129 | 0.4047 | 0.933 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0663 | 0.0663 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0195 | 0.6607 | 0.6607 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0043 | 0.0758 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.007 | 0.1804 | 0.1804 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.007 | 0.1804 | 0.2611 |
Toxoplasma gondii | ATP synthase F0 subunit 9, putative | 0.0129 | 0.4047 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0283 | 1 | 1 |
Plasmodium vivax | ATP synthase lipid-binding protein, mitochondrial precursor, putative | 0.0129 | 0.4047 | 1 |
Mycobacterium tuberculosis | Probable ATP synthase C chain AtpE (lipid-binding protein) (dicyclohexylcarbodiimide-binding protein) | 0.0129 | 0.4047 | 1 |
Schistosoma mansoni | lamin | 0.0032 | 0.0335 | 0.0484 |
Trypanosoma cruzi | ATPase subunit 9, putative | 0.0129 | 0.4047 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0032 | 0.0335 | 0.0335 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0195 | 0.6607 | 0.6607 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0195 | 0.6607 | 0.6607 |
Echinococcus granulosus | sodium channel protein | 0.0135 | 0.4283 | 0.4283 |
Echinococcus multilocularis | musashi | 0.0032 | 0.0335 | 0.0335 |
Brugia malayi | jmjC domain containing protein | 0.007 | 0.1804 | 0.1804 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0043 | 0.0758 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.1316 | 0.1316 |
Trypanosoma brucei | Mitochondrial ATP synthase subunit c-3 | 0.0129 | 0.4047 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.0335 | 0.0335 |
Onchocerca volvulus | 0.0032 | 0.0335 | 0.0973 | |
Trypanosoma brucei | hypothetical protein | 0.0112 | 0.3418 | 0.8088 |
Plasmodium falciparum | ATP synthase subunit C, putative | 0.0129 | 0.4047 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0043 | 0.0758 | 0.0758 |
Mycobacterium leprae | PROBABLE ATP SYNTHASE C CHAIN ATPE (LIPID-BINDING PROTEIN) (DICYCLOHEXYLCARBODIIMIDE-BINDING PROTEIN) | 0.0129 | 0.4047 | 0.5 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.007 | 0.1804 | 0.2611 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0043 | 0.0758 | 0.0758 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.007 | 0.1804 | 0.1804 |
Schistosoma mansoni | intermediate filament proteins | 0.0032 | 0.0335 | 0.0484 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.1892 | 0.3447 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.1892 | 0.2738 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.1316 | 0.1904 |
Echinococcus granulosus | lamin | 0.0032 | 0.0335 | 0.0335 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0143 | 0.4598 | 0.4598 |
Schistosoma mansoni | hypothetical protein | 0.0203 | 0.6908 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0143 | 0.4598 | 0.4598 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.1476 | 0.2137 |
Echinococcus multilocularis | mitochondrial ATP synthase subunit 9 | 0.0129 | 0.4047 | 0.4047 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0043 | 0.0758 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0043 | 0.0758 | 0.0758 |
Schistosoma mansoni | lamin | 0.0032 | 0.0335 | 0.0484 |
Leishmania major | ATPase subunit 9, putative | 0.0129 | 0.4047 | 0.933 |
Schistosoma mansoni | ATP synthase lipid-binding protein-like protein | 0.0129 | 0.4047 | 0.5858 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.139 | 0.139 |
Wolbachia endosymbiont of Brugia malayi | ATP synthase F0F1 subunit C | 0.0129 | 0.4047 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0663 | 0.0663 |
Trypanosoma cruzi | ATPase subunit 9, putative | 0.0129 | 0.4047 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.1892 | 0.3216 |
Trypanosoma cruzi | ATPase subunit 9, putative | 0.0129 | 0.4047 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0135 | 0.4283 | 0.4283 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0043 | 0.0758 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0168 | 0.556 | 0.8049 |
Trypanosoma cruzi | ATPase subunit 9, putative | 0.0129 | 0.4047 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0032 | 0.0335 | 0.0335 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0335 | 0.0335 |
Schistosoma mansoni | hypothetical protein | 0.0203 | 0.6908 | 1 |
Echinococcus granulosus | mitochondrial ATP synthase subunit 9 | 0.0129 | 0.4047 | 0.4047 |
Schistosoma mansoni | lipoxygenase | 0.0099 | 0.2894 | 0.419 |
Echinococcus multilocularis | geminin | 0.0203 | 0.6908 | 0.6908 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.139 | 0.139 |
Schistosoma mansoni | lipoxygenase | 0.0141 | 0.4532 | 0.656 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0043 | 0.0758 | 0.5 |
Echinococcus multilocularis | lamin | 0.0032 | 0.0335 | 0.0335 |
Schistosoma mansoni | alpha glucosidase | 0.0043 | 0.0758 | 0.1098 |
Echinococcus granulosus | geminin | 0.0203 | 0.6908 | 0.6908 |
Trypanosoma brucei | Mitochondrial ATP synthase subunit c-2 | 0.0129 | 0.4047 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0043 | 0.0758 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.1892 | 0.1892 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0135 | 0.4283 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.007 | 0.1804 | 0.1804 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0283 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0663 | 0.0959 |
Onchocerca volvulus | 0.0058 | 0.1316 | 0.3827 | |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.0335 | 0.0335 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.1892 | 0.1892 |
Trypanosoma cruzi | ATPase subunit 9, putative | 0.0129 | 0.4047 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0168 | 0.556 | 0.8049 |
Schistosoma mansoni | jumonji domain containing protein | 0.007 | 0.1804 | 0.2611 |
Onchocerca volvulus | 0.0032 | 0.0335 | 0.0973 | |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0043 | 0.0758 | 0.5 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.007 | 0.1804 | 0.1804 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.139 | 0.139 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.