TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 514.993 | Formula: C17H11Br3N2O2
H donors: 2 H acceptors: 2 LogP: 5.83 Rotable bonds: 3
Rule of 5 violations (Lipinski): 2
SMILES: Brc1ccc(cc1)Nc1[nH]c2c(Br)ccc(c2c(=O)c1C(=O)C)Br
InChi: 1S/C17H11Br3N2O2/c1-8(23)13-16(24)14-11(19)6-7-12(20)15(14)22-17(13)21-10-4-2-9(18)3-5-10/h2-7H,1H3,(H2,21,22,24)
InChiKey: KMZAXCJSAFYPSE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin L	Starlite/ChEMBL	References
Homo sapiens	calpain 1, (mu/I) large subunit	Starlite/ChEMBL	References
Homo sapiens	cathepsin B	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	family C2 unassigned peptidase C02 family	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	calpain family protein 1, d	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	calpain A	Get druggable targets OG5_127139	All targets in OG5_127139
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K08585 calpain, invertebrate, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_127139	All targets in OG5_127139
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Calpain-1 catalytic subunit, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Calpain-A, putative	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	calpain family protein 1	Get druggable targets OG5_127139	All targets in OG5_127139
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	Get druggable targets OG5_127139	All targets in OG5_127139
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127139	All targets in OG5_127139
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	calpain A	calpain 1, (mu/I) large subunit	714 aa	753 aa	31.7 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Cathepsin L-like precursor	0.0032	0.095	0.095
Loa Loa (eye worm)	fibroinase	0.0032	0.095	0.095
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.006	0.2759	1
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0098	0.103
Schistosoma mansoni	cathepsin F (C01 family)	0.0023	0.0369	0.0274
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.095	0.086
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.095	1
Onchocerca volvulus		0.0032	0.095	0.4962
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0486	0.0486
Echinococcus multilocularis	calpain family protein 1, d	0.0048	0.2026	0.1947
Loa Loa (eye worm)	cathepsin B	0.006	0.2759	0.2759
Echinococcus multilocularis	calpain 5	0.0025	0.0486	0.0392
Brugia malayi	Cathepsin L-like precursor	0.0032	0.095	0.095
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.095	0.086
Echinococcus multilocularis	cysteine protease	0.0032	0.095	0.086
Entamoeba histolytica	cysteine proteinase, putative	0.0023	0.0369	0.3884
Echinococcus multilocularis	calpain A	0.0069	0.3351	0.3286
Trypanosoma cruzi	cysteine proteinase, putative	0.0019	0.0098	0.0098
Plasmodium vivax	vivapain-2	0.0032	0.095	1
Entamoeba histolytica	cysteine proteinase 2	0.0019	0.0098	0.103
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	1	1
Echinococcus granulosus	cathepsin b	0.0171	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.095	0.3201
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.095	0.3201
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0025	0.0486	0.1763
Loa Loa (eye worm)	calpain	0.0025	0.0486	0.0486
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.095	0.086
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.095	0.3201
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0069	0.3351	0.3286
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0019	0.0098	0.0355
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.095	0.3201
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0098	0.103
Echinococcus granulosus	cathepsin l1	0.0023	0.0369	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0171	1	1
Leishmania major	cathepsin L-like protease	0.0032	0.095	0.3442
Trypanosoma brucei	antigen, putative	0.0025	0.0486	0.1763
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.095	0.3201
Schistosoma mansoni	calpain-7 (C02 family)	0.0025	0.0486	0.0392
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.095	0.3201
Plasmodium vivax	calpain, putative	0.0025	0.0486	0.456
Echinococcus granulosus	calpain	0.0025	0.0486	0.0392
Brugia malayi	calpain family protein 1	0.0066	0.3157	0.3157
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.095	0.3442
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.095	0.3201
Loa Loa (eye worm)	hypothetical protein	0.0048	0.2026	0.2026
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.095	0.095
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0032	0.095	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.095	0.3201
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0486	0.0486
Leishmania major	cathepsin L-like protease	0.0032	0.095	0.3442
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0369	0.0369
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.095	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0369	0.1018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.095	0.3201
Brugia malayi	Cathepsin L-like precursor	0.0032	0.095	0.095
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.095	0.3201
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.095	0.3442
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0486	0.0486
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.095	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0486	0.0486
Leishmania major	cysteine peptidase A (CPA)	0.0032	0.095	0.3442
Loa Loa (eye worm)	calpain family protein 1	0.0048	0.2026	0.2026
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.095	0.3201
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.095	0.095
Echinococcus granulosus	calpain 7 C02 family	0.0025	0.0486	0.0392
Schistosoma mansoni	cathepsin F (C01 family)	0.0032	0.095	0.086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.095	0.3201
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	1	1
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0025	0.0486	0.0392
Trypanosoma brucei	cysteine peptidase C (CPC)	0.006	0.2759	1
Leishmania major	cathepsin L-like protease	0.0032	0.095	0.3442
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0032	0.095	0.086
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0486	0.1763
Echinococcus granulosus	calpain A	0.0025	0.0486	0.0392
Onchocerca volvulus		0.0032	0.095	0.4962
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.095	0.095
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.006	0.2759	0.2688
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0098	0.103
Brugia malayi	Cathepsin L-like precursor	0.0032	0.095	0.095
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0032	0.095	0.086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.095	0.3442
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.095	0.3442
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0032	0.095	0.095
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0098	0.103
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.095	0.3201
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0023	0.0369	0.0369
Brugia malayi	Cathepsin L-like precursor	0.0032	0.095	0.095
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0032	0.095	1
Trypanosoma cruzi	cysteine protease, putative	0.0019	0.0098	0.0098
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0486	0.1763
Loa Loa (eye worm)	cysteine protease	0.0032	0.095	0.095
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.095	0.095
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0098	0.103
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.095	0.095
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0369	0.0369
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0066	0.3157	0.3089
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.095	0.3442
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.095	0.3442
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0486	0.0486
Brugia malayi	calpain 7	0.0025	0.0486	0.0486
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.095	0.3201
Brugia malayi	Cathepsin L-like precursor	0.0032	0.095	0.095
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0486	0.0486
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.095	0.3201
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0486	0.1763
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0486	0.0486
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0032	0.095	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.095	0.3201
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0098	0.103
Loa Loa (eye worm)	hypothetical protein	0.0032	0.095	0.095
Onchocerca volvulus		0.0032	0.095	0.4962
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0098	0.103
Trypanosoma cruzi	cysteine peptidase, putative	0.0019	0.0098	0.0098
Echinococcus granulosus	calpain A	0.0069	0.3351	0.3286
Leishmania major	cathepsin L-like protease	0.0032	0.095	0.3442
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0069	0.3351	0.3286
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0032	0.095	0.086
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.095	0.3442
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0369	0.0369
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0098	0.103
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.095	0.3442
Trypanosoma brucei	calpain-like protein, putative	0.0025	0.0486	0.1763
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0023	0.0369	0.0369
Echinococcus multilocularis	hypothetical protein	0.0025	0.0486	0.0392
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.006	0.2759	0.2759
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0098	0.103
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0486	0.0486
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0069	0.3351	0.3286
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0098	0.103
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0098	0.103
Loa Loa (eye worm)	hypothetical protein	0.0058	0.2671	0.2671
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.095	0.3201
Trypanosoma cruzi	cysteine proteinase, putative	0.0019	0.0098	0.0098
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0369	0.1018
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0098	0.103
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.095	0.3442
Giardia lamblia	Cathepsin B precursor	0.006	0.2759	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.095	0.3201
Brugia malayi	cathepsin L-like precursor	0.0023	0.0369	0.0369
Trypanosoma brucei	calpain-like protein, putative	0.0025	0.0486	0.1763
Loa Loa (eye worm)	ctsf protein	0.0032	0.095	0.095
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0025	0.0486	0.0486
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0019	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1539	0.1539
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.095	0.3201
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.095	0.3442
Echinococcus multilocularis	cathepsin b	0.0171	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.095	0.3201
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0032	0.095	1
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0025	0.0486	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0369	0.0369
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0032	0.095	0.095
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0171	1	1
Giardia lamblia	Cathepsin B precursor	0.006	0.2759	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0098	0.103
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0098	0.0098
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.095	0.4962
Plasmodium vivax	vivapain-2	0.0032	0.095	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.095	0.3201
Onchocerca volvulus		0.0032	0.095	0.4962
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0069	0.3351	0.3286
Onchocerca volvulus		0.0032	0.095	0.4962
Onchocerca volvulus		0.0041	0.1539	1
Onchocerca volvulus		0.0032	0.095	0.4962
Schistosoma mansoni	calpain-7 (C02 family)	0.0025	0.0486	0.0392
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0098	0.103
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0032	0.095	0.3442
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0025	0.0486	0.1763
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0098	0.103
Onchocerca volvulus	Cathepsin L homolog	0.0032	0.095	0.4962
Echinococcus granulosus	calpain 5	0.0025	0.0486	0.0392
Schistosoma mansoni	calpain C (C02 family)	0.0025	0.0486	0.0392
Echinococcus multilocularis	cathepsin b	0.0171	1	1
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0098	0.103
Schistosoma mansoni	calpain (C02 family)	0.0025	0.0486	0.0392
Toxoplasma gondii	cathepsin B	0.006	0.2759	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.095	0.3201
Entamoeba histolytica	cysteine proteinase 1, putative	0.0019	0.0098	0.103
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0171	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0032	0.095	0.086
Leishmania major	cathepsin L-like protease	0.0032	0.095	0.3442
Leishmania major	cathepsin L-like protease	0.0032	0.095	0.3442
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0098	0.103
Echinococcus multilocularis	calpain 7 (C02 family)	0.0025	0.0486	0.0392
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0032	0.095	0.3201
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0098	0.0098
Loa Loa (eye worm)	calpain family protein 1	0.0066	0.3157	0.3157
Loa Loa (eye worm)	hypothetical protein	0.0066	0.3157	0.3157
Giardia lamblia	Cathepsin B precursor	0.006	0.2759	0.5
Trypanosoma brucei	calpain-like protein, putative	0.0025	0.0486	0.1763
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.006	0.2759	1
Echinococcus granulosus	cathepsin l1	0.0032	0.095	0.086
Brugia malayi	Cathepsin L-like precursor	0.0023	0.0369	0.0369
Trypanosoma brucei	calpain-like protein, putative	0.0025	0.0486	0.1763
Echinococcus multilocularis	cysteine protease	0.0032	0.095	0.086
Brugia malayi	calpain family protein 1	0.0066	0.3157	0.3157
Leishmania major	cathepsin L-like protease	0.0032	0.095	0.3442
Onchocerca volvulus	Cathepsin F homolog	0.0032	0.095	0.4962
Trypanosoma cruzi	cruzipain precursor, putative	0.0032	0.095	0.095
Echinococcus multilocularis	calpain	0.0025	0.0486	0.0392
Echinococcus granulosus	cathepsin b	0.0171	1	1
Leishmania major	cathepsin L-like protease	0.0032	0.095	0.3442
Entamoeba histolytica	cysteine protease, putative	0.0032	0.095	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0019	0.0098	0.0355
Onchocerca volvulus		0.0032	0.095	0.4962

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.06 uM	Inhibition of human liver cathepsin L after 30 mins by fluorometric end-point assay	ChEMBL.	19419206
IC50 (binding)	= 1.64 uM	Inhibition of human liver cathepsin B after 30 mins by fluorometric end-point assay	ChEMBL.	19419206
IC50 (binding)	= 1.69 uM	Inhibition of human erythrocytes mu-calpain by fluorometric assay using pep2 as substrate	ChEMBL.	19419206
IC50 (binding)	= 3.59 uM	Inhibition of human erythrocytes mu-calpain after 30 mins by fluorometric assay using pep1 as substrate	ChEMBL.	19419206
IC50 (binding)	= 91.76 uM	Inhibition of human liver cathepsin H after 30 mins by fluorometric end-point assay	ChEMBL.	19419206
IC50 (binding)	> 100 uM	Inhibition of human liver cathepsin D after 30 mins by fluorometric end-point assay	ChEMBL.	19419206

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL470707

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 976387