Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 14 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | beta-N-acetylhexosaminidase, beta subunit | 0.02 | 0.0754 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0125 | 0 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0125 | 0 | 0.5 |
Brugia malayi | Glycosyl hydrolase family 20, catalytic domain containing protein | 0.02 | 0.0754 | 0.0497 |
Loa Loa (eye worm) | hyaluronidase | 0.1122 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.027 | 0.027 |
Echinococcus granulosus | beta hexosaminidase subunit beta | 0.02 | 0.0754 | 0.0754 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.027 | 0.5 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.1122 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.027 | 0.027 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, alpha subunit | 0.02 | 0.0754 | 0.5 |
Echinococcus multilocularis | beta hexosaminidase subunit beta | 0.02 | 0.0754 | 0.0754 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.027 | 0.5 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.02 | 0.0754 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.027 | 0.027 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.02 | 0.0754 | 0.5 |
Schistosoma mansoni | Hyaluronidase | 0.1122 | 1 | 1 |
Trichomonas vaginalis | beta-hexosaminidase B, putative | 0.0125 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0477 | 0.3526 | 0.3347 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.1122 | 1 | 1 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0152 | 0.027 | 0.5 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0152 | 0.027 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0152 | 0.027 | 0.027 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0152 | 0.027 | 0.027 |
Loa Loa (eye worm) | glycosyl hydrolase family 20 | 0.02 | 0.0754 | 0.0497 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.027 | 0.027 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0125 | 0 | 0.5 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.1122 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 4.6 nM | Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl}methyl)amino]carbonyl}benzoic acid from human p38alpha by fluorescence polarization | ChEMBL. | 18602262 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.