Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0077 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0077 | 1 | 1 |
Leishmania major | deoxyhypusine synthase, putative | 0.0072 | 0.9005 | 0.9005 |
Echinococcus granulosus | deoxyhypusine synthase | 0.0072 | 0.9005 | 0.8394 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0077 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0047 | 0.3805 | 0.3805 |
Echinococcus multilocularis | deoxyhypusine synthase | 0.0072 | 0.9005 | 0.8394 |
Trypanosoma cruzi | p450 reductase, putative | 0.0077 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0047 | 0.3805 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0077 | 1 | 1 |
Brugia malayi | deoxyhypusine synthase | 0.0072 | 0.9005 | 0.9005 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0077 | 1 | 1 |
Trypanosoma cruzi | deoxyhypusine synthase, putative | 0.0072 | 0.9005 | 0.9005 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0077 | 1 | 1 |
Entamoeba histolytica | deoxyhypusine synthase, putative | 0.0072 | 0.9005 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0077 | 1 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0068 | 0.8159 | 0.8159 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0047 | 0.3805 | 0.2407 |
Toxoplasma gondii | deoxyhypusine synthase | 0.0072 | 0.9005 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0077 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0077 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0077 | 1 | 1 |
Plasmodium vivax | deoxyhypusine synthase, putative | 0.0072 | 0.9005 | 0.9005 |
Schistosoma mansoni | deoxyhypusine synthase | 0.0072 | 0.9005 | 0.8781 |
Trypanosoma brucei | deoxyhypusine synthase | 0.0072 | 0.9005 | 0.9005 |
Entamoeba histolytica | deoxyhypusine synthase, putative | 0.0072 | 0.9005 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0077 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0077 | 1 | 1 |
Giardia lamblia | Deoxyhypusine synthase, putative | 0.0072 | 0.9005 | 1 |
Plasmodium falciparum | deoxyhypusine synthase | 0.0072 | 0.9005 | 0.9005 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0077 | 1 | 1 |
Loa Loa (eye worm) | deoxyhypusine synthase | 0.0072 | 0.9005 | 0.9005 |
Trichomonas vaginalis | deoxyhypusine synthase, putative | 0.0072 | 0.9005 | 0.9005 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0047 | 0.3805 | 0.3805 |
Treponema pallidum | flavodoxin | 0.0029 | 0 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0068 | 0.8159 | 0.8159 |
Brugia malayi | FAD binding domain containing protein | 0.0077 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0077 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0077 | 1 | 0.5 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0077 | 1 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0068 | 0.8159 | 0.8159 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0077 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0077 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0039 | 0.1964 | 0.0151 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0077 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 8.5 % | Antiproliferative activity against human HeLa cells at 1 uM after 24 hrs by sulforhodamine B assay | ChEMBL. | 18708272 |
Inhibition (functional) | = 20 % | Antiproliferative activity against human HeLa cells at 5 uM after 24 hrs by sulforhodamine B assay | ChEMBL. | 18708272 |
Inhibition (functional) | = 77 % | Antiproliferative activity against human HeLa cells at 20 uM after 24 hrs by sulforhodamine B assay | ChEMBL. | 18708272 |
MIC (functional) | = 25 ug ml-1 | Antibacterial activity against Escherichia coli after 24 hrs by broth microdilution method | ChEMBL. | 19349095 |
MIC (functional) | > 50 ug ml-1 | Antifungal activity against Candida albicans after 48 hrs by micro broth dilution method | ChEMBL. | 18708272 |
MIC (functional) | > 50 ug ml-1 | Antifungal activity against Cryptococcus neoformans after 72 hrs by micro broth dilution method | ChEMBL. | 18708272 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.