Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 14 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0477 | 0.3526 | 0.3347 |
Trichomonas vaginalis | beta-hexosaminidase B, putative | 0.0125 | 0 | 0.5 |
Schistosoma mansoni | Hyaluronidase | 0.1122 | 1 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.02 | 0.0754 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.027 | 0.027 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.1122 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0152 | 0.027 | 0.027 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.027 | 0.027 |
Loa Loa (eye worm) | glycosyl hydrolase family 20 | 0.02 | 0.0754 | 0.0497 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0125 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0152 | 0.027 | 0.027 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.1122 | 1 | 1 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0152 | 0.027 | 0.5 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0152 | 0.027 | 0.5 |
Brugia malayi | Glycosyl hydrolase family 20, catalytic domain containing protein | 0.02 | 0.0754 | 0.0497 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.027 | 0.027 |
Loa Loa (eye worm) | hyaluronidase | 0.1122 | 1 | 1 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, beta subunit | 0.02 | 0.0754 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0125 | 0 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0125 | 0 | 0.5 |
Echinococcus multilocularis | beta hexosaminidase subunit beta | 0.02 | 0.0754 | 0.0754 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, putative | 0.02 | 0.0754 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.027 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.027 | 0.027 |
Entamoeba histolytica | beta-N-acetylhexosaminidase, alpha subunit | 0.02 | 0.0754 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.027 | 0.5 |
Echinococcus granulosus | beta hexosaminidase subunit beta | 0.02 | 0.0754 | 0.0754 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.1122 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.2 nM | Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl}methyl)amino]carbonyl}benzoic acid from human p38alpha by fluorescence polarization | ChEMBL. | 18602262 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.