Detailed information for compound 983286

Basic information

Technical information
  • TDR Targets ID: 983286
  • Name: 2-(6,7-dimethoxyquinolin-4-yl)oxy-5-methylben zaldehyde
  • MW: 323.343 | Formula: C19H17NO4
  • H donors: 0 H acceptors: 2 LogP: 3.49 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2c(ccnc2cc1OC)Oc1ccc(cc1C=O)C
  • InChi: 1S/C19H17NO4/c1-12-4-5-16(13(8-12)11-21)24-17-6-7-20-15-10-19(23-3)18(22-2)9-14(15)17/h4-11H,1-3H3
  • InChiKey: LTMDRCPCNIVSOU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(6,7-dimethoxy-4-quinolyl)oxy]-5-methyl-benzaldehyde
  • 2-[(6,7-dimethoxy-4-quinolyl)oxy]-5-methylbenzaldehyde
  • 2-(6,7-dimethoxyquinolin-4-yl)oxy-5-methyl-benzaldehyde

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0391 0.0848
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4295 1
Plasmodium vivax heat shock protein, putative 0.0169 0.2416 1
Plasmodium vivax hypothetical protein, conserved 0.0045 0.0393 0.1083
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.011 0.1459 0.2215
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0087 0.0241
Trichomonas vaginalis aldo/keto reductase, putative 0.0064 0.0701 0.146
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4295 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4295 1
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0611 0.9601 0.9597
Echinococcus multilocularis heat shock protein 0.0045 0.0391 0.1034
Trichomonas vaginalis CMGC family protein kinase 0.011 0.1459 0.3262
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0099 0.0151
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0701 0.1856
Trypanosoma cruzi heat shock protein, putative 0.003 0.0147 0.0824
Leishmania major cytochrome p450-like protein 0.0027 0.0099 0.0487
Trypanosoma brucei prostaglandin f synthase 0.0064 0.0701 0.4699
Echinococcus granulosus aldehyde reductase 0.0045 0.0401 0.1062
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.059 0.9272 0.9645
Mycobacterium tuberculosis Possible oxidoreductase 0.0045 0.0393 0.005
Echinococcus multilocularis endoplasmin 0.0042 0.0346 0.0916
Plasmodium vivax heat shock protein 86, putative 0.0045 0.0391 0.1074
Echinococcus multilocularis aldo keto reductase 0.0064 0.0701 0.1856
Entamoeba histolytica heat shock transcription factor, putative 0.0096 0.1224 0.2801
Loa Loa (eye worm) hypothetical protein 0.0045 0.0393 0.0597
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0045 0.0393 0.0297
Brugia malayi Cytochrome P450 family protein 0.0056 0.0581 0.2887
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0701 0.1856
Entamoeba histolytica aldose reductase, putative 0.0064 0.0701 0.1575
Onchocerca volvulus 0.0107 0.1415 0.2147
Echinococcus multilocularis 0.0045 0.0393 0.104
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0099 0.0151
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0057 0.0599 0.1217
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0045 0.0393 0.1083
Trichomonas vaginalis endoplasmin, putative 0.0032 0.0192 0.0249
Plasmodium falciparum heat shock protein 90, putative 0.0169 0.2416 1
Leishmania major heat shock protein 83-1 0.0045 0.0391 0.2528
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0147 0.039
Loa Loa (eye worm) oxidoreductase 0.0064 0.0701 0.1065
Brugia malayi SWIRM domain containing protein 0.0045 0.0393 0.1952
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.0391 0.2528
Loa Loa (eye worm) hypothetical protein 0.0144 0.2014 0.3057
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0346 0.0616
Schistosoma mansoni amine oxidase 0.0045 0.0393 0.0976
Brugia malayi amine oxidase, flavin-containing family protein 0.0045 0.0393 0.1952
Echinococcus granulosus lysine specific histone demethylase 1A 0.0045 0.0393 0.104
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.011 0.1459 1
Leishmania major heat shock protein 83-1 0.0045 0.0391 0.2528
Loa Loa (eye worm) hypothetical protein 0.009 0.1123 0.1704
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0391 0.2528
Echinococcus multilocularis muscleblind protein 1 0.0144 0.2014 0.5327
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0107 0.1415 0.7025
Leishmania major heat shock protein, putative 0.003 0.0147 0.0824
Loa Loa (eye worm) hypothetical protein 0.0045 0.0393 0.0597
Loa Loa (eye worm) hypothetical protein 0.0045 0.0393 0.0597
Trypanosoma cruzi UDP-galactopyranose mutase 0.0045 0.0393 0.2542
Trichomonas vaginalis CMGC family protein kinase 0.011 0.1459 0.3262
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.1927 0.1846
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0701 0.1856
Schistosoma mansoni serine/threonine protein kinase 0.011 0.1459 0.3623
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0701 0.1856
Schistosoma mansoni heat shock protein 0.0045 0.0391 0.0971
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4295 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0455 0.2259
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.011 0.1459 1
Onchocerca volvulus 0.0064 0.0701 0.1065
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.0391 0.2528
Mycobacterium ulcerans dehydrogenase 0.0045 0.0393 0.0297
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0701 0.1856
Onchocerca volvulus 0.0045 0.0393 0.0597
Giardia lamblia Kinase, CMGC MAPK 0.011 0.1459 0.2927
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0391 0.0262
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0045 0.0393 0.1523
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0701 0.146
Trichomonas vaginalis aldo/keto reductase, putative 0.0064 0.0701 0.146
Loa Loa (eye worm) hypothetical protein 0.0107 0.1415 0.2147
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0701 0.146
Brugia malayi Peptidase family C54 containing protein 0.0057 0.0599 0.2976
Plasmodium falciparum heat shock protein 90 0.0045 0.0391 0.1515
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0701 0.1856
Mycobacterium ulcerans monoamine oxidase 0.0045 0.0393 0.0297
Trypanosoma brucei heat shock protein, putative 0.0045 0.0391 0.2528
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0701 0.146
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.011 0.1459 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0064 0.0701 0.3483
Leishmania major heat shock protein 83-1 0.0045 0.0391 0.2528
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0701 0.1856
Echinococcus multilocularis mitogen activated protein kinase 0.011 0.1459 0.3861
Loa Loa (eye worm) hypothetical protein 0.0045 0.0393 0.0597
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0701 0.1856
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0045 0.0393 0.1523
Leishmania major heat shock protein 83-1 0.0045 0.0391 0.2528
Trypanosoma brucei cytochrome P450, putative 0.0027 0.0099 0.0487
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0455 0.069
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0701 0.1856
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0701 0.1856
Mycobacterium ulcerans oxidoreductase 0.0045 0.0393 0.0297
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.0346 0.5
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0045 0.0393 0.0976
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0611 0.9601 1
Trypanosoma brucei heat shock protein, putative 0.0045 0.0391 0.2528
Echinococcus multilocularis heat shock protein 90 0.0038 0.0286 0.0757
Echinococcus granulosus aldo keto reductase 0.0064 0.0701 0.1856
Mycobacterium tuberculosis Conserved hypothetical protein 0.0045 0.0393 0.005
Echinococcus granulosus hypothetical protein 0.0064 0.0701 0.1856
Loa Loa (eye worm) oxidoreductase 0.0064 0.0701 0.1065
Echinococcus granulosus cysteine protease atg4b 0.0057 0.0599 0.1586
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0701 0.146
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0701 0.1856
Echinococcus multilocularis aldo keto reductase 0.0064 0.0701 0.1856
Leishmania major heat shock protein 83-1 0.0045 0.0391 0.2528
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0701 0.1856
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0701 0.146
Leishmania major heat shock protein 83-1 0.0045 0.0391 0.2528
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0701 0.1856
Schistosoma mansoni amine oxidase 0.0045 0.0393 0.0976
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0701 0.1856
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0147 0.0224
Loa Loa (eye worm) heat shock protein 75 0.003 0.0147 0.0224
Plasmodium vivax hypothetical protein, conserved 0.0045 0.0393 0.1083
Trypanosoma cruzi aldo-keto reductase 0.0064 0.0701 0.4699
Toxoplasma gondii Hsp90 domain-containing protein 0.0169 0.2416 1
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.0268 0.4028 1
Toxoplasma gondii heat shock protein HSP90 0.0045 0.0391 0.1515
Loa Loa (eye worm) hypothetical protein 0.0064 0.0701 0.1065
Echinococcus granulosus mitogen activated protein kinase 3 0.011 0.1459 0.3861
Entamoeba histolytica heat shock transcription factor, putative 0.0096 0.1224 0.2801
Giardia lamblia Aldose reductase 0.0064 0.0701 0.1036
Leishmania major heat shock protein 83-1 0.0045 0.0391 0.2528
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0099 0.0487
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0064 0.0701 0.146
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0701 0.1856
Trypanosoma cruzi UDP-galactopyranose mutase 0.0045 0.0393 0.2542
Leishmania major UDP-galactopyranose mutase 0.0045 0.0393 0.2542
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.011 0.1459 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.011 0.1459 0.3861
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0391 0.2528
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0064 0.0701 0.146
Onchocerca volvulus 0.0064 0.0701 0.1065
Giardia lamblia Grp94/Hsp90 0.0042 0.0346 0.015
Echinococcus granulosus muscleblind protein 0.0144 0.2014 0.5327
Echinococcus granulosus endoplasmin 0.0042 0.0346 0.0916
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0064 0.0701 0.4699
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0147 0.0824
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0057 0.0599 0.1217
Mycobacterium ulcerans oxidoreductase 0.0064 0.0701 0.0608
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0057 0.0599 0.1488
Loa Loa (eye worm) hypothetical protein 0.0045 0.0393 0.0597
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0701 0.146
Leishmania major heat shock protein 83-1 0.0045 0.0391 0.2528
Leishmania major aldo-keto reductase-like protein 0.0064 0.0701 0.4699
Loa Loa (eye worm) hypothetical protein 0.0049 0.0455 0.069
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4295 1
Schistosoma mansoni endoplasmin 0.0045 0.0391 0.0971
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.4295 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0045 0.0393 0.104
Loa Loa (eye worm) hypothetical protein 0.0033 0.0205 0.0311
Echinococcus granulosus aldo keto reductase 0.0064 0.0701 0.1856
Leishmania major heat shock protein 83-1 0.0045 0.0391 0.2528
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0286 0.1795
Entamoeba histolytica aldose reductase, putative 0.0064 0.0701 0.1575
Echinococcus multilocularis Peptidase C54 0.0057 0.0599 0.1586
Leishmania major heat shock protein 83-1 0.0045 0.0391 0.2528
Onchocerca volvulus 0.0064 0.0701 0.1065
Echinococcus multilocularis heat shock protein 90 0.0045 0.0391 0.1034
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.4295 1
Echinococcus multilocularis aldehyde reductase 0.0045 0.0401 0.1062
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0701 0.1856
Plasmodium falciparum protoporphyrinogen oxidase 0.0045 0.0393 0.1523
Trypanosoma brucei heat shock protein, putative 0.0045 0.0391 0.2528
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0057 0.0599 0.3985
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0045 0.0393 0.0295
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0701 0.146
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0391 0.2528
Loa Loa (eye worm) oxidoreductase 0.0064 0.0701 0.1065
Leishmania major heat shock protein 83-1 0.0045 0.0391 0.2528
Brugia malayi Phospholipase A2 family protein 0.009 0.1123 0.5575
Trypanosoma brucei heat shock protein, putative 0.0045 0.0391 0.2528
Brugia malayi Muscleblind-like protein 0.0144 0.2014 1
Schistosoma mansoni endoplasmin 0.0045 0.0391 0.0971
Onchocerca volvulus 0.0064 0.0701 0.1065
Schistosoma mansoni hypothetical protein 0.0268 0.4028 1
Entamoeba histolytica aldose reductase, putative 0.0064 0.0701 0.1575
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0057 0.0599 0.1217
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.1927 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.011 0.1459 1
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0346 0.0616
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.0253 0.378 1
Leishmania major prostaglandin f synthase, putative 0.0064 0.0701 0.4699
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0205 0.1018
Schistosoma mansoni aldo-keto reductase 0.0064 0.0701 0.1741
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0391 0.0848
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0701 0.146
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4295 1
Toxoplasma gondii aldose reductase, putative 0.0064 0.0701 0.2816
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0701 0.1856
Echinococcus multilocularis aldo keto reductase 0.0064 0.0701 0.1856
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4295 1
Plasmodium falciparum endoplasmin, putative 0.0032 0.0192 0.0681
Schistosoma mansoni hypothetical protein 0.0033 0.0205 0.0509
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0096 0.1224 0.1858
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0064 0.0701 0.3483
Loa Loa (eye worm) oxidoreductase 0.0064 0.0701 0.1065
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0057 0.0599 0.1488
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0057 0.0599 0.1217
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.0253 0.378 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0455 0.2259
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0391 0.0722
Echinococcus multilocularis aldo keto reductase 0.0064 0.0701 0.1856
Trichomonas vaginalis CMGC family protein kinase 0.011 0.1459 0.3262
Echinococcus granulosus aldo keto reductase 0.0064 0.0701 0.1856
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0064 0.0701 0.3483
Trichomonas vaginalis aldo/keto reductase, putative 0.0064 0.0701 0.146
Brugia malayi MAP kinase sur-1 0.011 0.1459 0.7247
Loa Loa (eye worm) CYP4Cod1 0.0027 0.0099 0.0151
Brugia malayi Hsp90 protein 0.003 0.0147 0.0732
Trypanosoma cruzi aldo/keto reductase, putative 0.0064 0.0701 0.4699
Loa Loa (eye worm) hypothetical protein 0.0144 0.2014 0.3057
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.4295 1
Entamoeba histolytica heat shock transcription factor, putative 0.0096 0.1224 0.2801
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0064 0.0701 0.1856
Brugia malayi heat shock protein 90 0.0045 0.0391 0.1942
Echinococcus granulosus lysine specific histone demethylase 1A 0.0045 0.0393 0.104
Onchocerca volvulus 0.0064 0.0701 0.1065
Leishmania major heat shock protein 83-1 0.0045 0.0391 0.2528
Trichomonas vaginalis CMGC family protein kinase 0.011 0.1459 0.3262
Brugia malayi hypothetical protein 0.0045 0.0393 0.1952
Loa Loa (eye worm) hypothetical protein 0.0057 0.0599 0.091
Onchocerca volvulus Phospholipase A2 homolog 0.009 0.1123 0.1704
Leishmania major heat shock protein 83-1 0.0045 0.0391 0.2528
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0064 0.0701 0.4699
Brugia malayi Cytochrome P450 family protein 0.0027 0.0099 0.0492
Mycobacterium leprae Conserved hypothetical protein 0.0045 0.0401 0.0347
Entamoeba histolytica peptidase, C54 family 0.0057 0.0599 0.1336
Trypanosoma brucei heat shock protein, putative 0.0045 0.0391 0.2528
Toxoplasma gondii histone lysine-specific demethylase 0.0045 0.0393 0.1523
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.0286 0.0757
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0701 0.146
Echinococcus multilocularis cysteine protease atg4b 0.0057 0.0599 0.1586
Echinococcus multilocularis protoporphyrinogen oxidase 0.0045 0.0393 0.104
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.1927 0.1708
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0391 0.2528
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0701 0.146
Echinococcus granulosus heat shock protein 90 0.0045 0.0391 0.1034
Chlamydia trachomatis protoporphyrinogen oxidase 0.0045 0.0393 0.5
Loa Loa (eye worm) hypothetical protein 0.0096 0.1224 0.1858
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0286 0.1795
Mycobacterium tuberculosis Probable oxidoreductase 0.0064 0.0701 0.0384
Onchocerca volvulus Phospholipase A2 homolog 0.0425 0.6588 1
Schistosoma mansoni aldo-keto reductase 0.0064 0.0701 0.1741
Leishmania major heat shock protein 83-1 0.0045 0.0391 0.2528
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0391 0.2528
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0057 0.0599 0.3985
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0581 0.0882
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0701 0.1856
Schistosoma mansoni heat shock protein 0.003 0.0147 0.0366
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0064 0.0701 0.3483
Schistosoma mansoni pol-related 0.0064 0.0701 0.1741
Brugia malayi Endoplasmin precursor 0.0045 0.0391 0.1942
Loa Loa (eye worm) hypothetical protein 0.0425 0.6588 1
Echinococcus granulosus Peptidase C54 0.0057 0.0599 0.1586
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0064 0.0701 0.1856
Loa Loa (eye worm) heat shock protein 90 0.0045 0.0391 0.0594
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.011 0.1459 1
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0391 0.2528
Giardia lamblia Aldose reductase 0.0064 0.0701 0.1036
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.0391 0.1515
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0064 0.0701 0.146
Onchocerca volvulus 0.0064 0.0701 0.1065
Trypanosoma brucei protein kinase, putative 0.011 0.1459 1
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.0346 0.2216
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0286 0.0473
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0045 0.0393 0.0976
Loa Loa (eye worm) oxidoreductase 0.0064 0.0701 0.1065
Echinococcus granulosus heat shock protein 0.0045 0.0391 0.1034
Schistosoma mansoni autophagin-1 (C54 family) 0.0057 0.0599 0.1488
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0057 0.0599 0.1217
Echinococcus granulosus mitogen activated protein kinase 0.011 0.1459 0.3861
Mycobacterium ulcerans heat shock protein 90 0.0042 0.0346 0.025
Trypanosoma brucei heat shock protein, putative 0.0045 0.0391 0.2528
Plasmodium vivax endoplasmin, putative 0.0045 0.0391 0.1074
Trypanosoma brucei heat shock protein, putative 0.0045 0.0391 0.2528
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0045 0.0393 0.1523
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0147 0.039
Brugia malayi HSF-type DNA-binding domain containing protein 0.0096 0.1224 0.6079
Echinococcus granulosus heat shock protein 90 0.0038 0.0286 0.0757
Brugia malayi Cytochrome P450 family protein 0.0027 0.0099 0.0492
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0147 0.0276
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0635 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0027 0.0099 0.0487
Echinococcus multilocularis muscleblind protein 0.0144 0.2014 0.5327
Schistosoma mansoni heat shock protein 0.0045 0.0391 0.0971
Leishmania major heat shock protein 83-1 0.0045 0.0391 0.2528
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0045 0.0393 0.1083
Loa Loa (eye worm) endoplasmin 0.0045 0.0391 0.0594
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.4295 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0701 0.146
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0192 0.0249
Loa Loa (eye worm) hypothetical protein 0.0045 0.0393 0.0597
Trypanosoma brucei heat shock protein, putative 0.0045 0.0391 0.2528
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0057 0.0599 0.3985
Leishmania major heat shock protein 83-1 0.0045 0.0391 0.2528
Trypanosoma brucei aldo-keto reductase, putative 0.0064 0.0701 0.4699
Trichomonas vaginalis aldo-keto reductase, putative 0.0064 0.0701 0.146
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.011 0.1459 0.5992
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0147 0.0494
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0064 0.0701 0.2246
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.011 0.1459 1
Leishmania major heat shock protein 83-1 0.0045 0.0391 0.2528
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.4295 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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