Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0092 | 0.2781 | 0.2781 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0278 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0092 | 0.2781 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 1 | 1 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0053 | 0.1278 | 0.1278 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0053 | 0.1278 | 0.1278 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1046 | 0.1046 |
Echinococcus granulosus | cathepsin b | 0.0278 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0278 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0278 | 1 | 1 |
Brugia malayi | calpain family protein 1 | 0.0053 | 0.1278 | 0.1278 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0092 | 0.2781 | 0.5 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0055 | 0.1371 | 0.1371 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0504 | 0.0504 |
Loa Loa (eye worm) | cathepsin B | 0.0092 | 0.2781 | 0.2781 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0092 | 0.2781 | 1 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0039 | 0.0737 | 0.0737 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0055 | 0.1371 | 0.1371 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0039 | 0.0737 | 0.0737 |
Echinococcus granulosus | calpain A | 0.0055 | 0.1371 | 0.1371 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0278 | 1 | 1 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0092 | 0.2781 | 1 |
Echinococcus multilocularis | calpain A | 0.0055 | 0.1371 | 0.1371 |
Brugia malayi | calpain family protein 1 | 0.0053 | 0.1278 | 0.1278 |
Plasmodium vivax | calpain, putative | 0.002 | 0 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.0092 | 0.2781 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0278 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0278 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0737 | 0.0737 |
Echinococcus granulosus | cathepsin b | 0.0278 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1278 | 0.1278 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0055 | 0.1371 | 0.1371 |
Giardia lamblia | Cathepsin B precursor | 0.0092 | 0.2781 | 0.5 |
Toxoplasma gondii | cathepsin B | 0.0092 | 0.2781 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0092 | 0.2781 | 0.2781 |
Echinococcus multilocularis | cathepsin b | 0.0278 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 0.0504 | 0.5 | |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0055 | 0.1371 | 0.1371 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 58.2 % | Peripheral analgesic activity in Swiss albino mouse assessed as protection against acetic acid-induced writhing response at 20 mg/kg, po administered 30 mins before acetic acid challenge measured after 3 hrs relative to control | ChEMBL. | 18462840 |
Activity (functional) | = 69 % | Peripheral analgesic activity in Swiss albino mouse assessed as protection against acetic acid-induced writhing response at 20 mg/kg, po administered 30 mins before acetic acid challenge measured after 30 mins relative to control | ChEMBL. | 18462840 |
Activity (functional) | = 74 % | Peripheral analgesic activity in Swiss albino mouse assessed as protection against acetic acid-induced writhing response at 20 mg/kg, po administered 30 mins before acetic acid challenge measured after 1 hr relative to control | ChEMBL. | 18462840 |
Activity (functional) | = 75.4 % | Peripheral analgesic activity in Swiss albino mouse assessed as protection against acetic acid-induced writhing response at 20 mg/kg, po administered 30 mins before acetic acid challenge measured after 2 hrs relative to control | ChEMBL. | 18462840 |
Activity (functional) | = 9.84 min | Central analgesic activity in Swiss albino mouse assessed as thermal stimuli reaction time at 20 mg/kg, po after 30 mins by hot plate method | ChEMBL. | 18462840 |
Activity (functional) | = 11.62 min | Central analgesic activity in Swiss albino mouse assessed as thermal stimuli reaction time at 20 mg/kg, po after 60 mins by hot plate method | ChEMBL. | 18462840 |
Activity (functional) | = 11.88 min | Central analgesic activity in Swiss albino mouse assessed as thermal stimuli reaction time at 20 mg/kg, po after 90 mins by hot plate method | ChEMBL. | 18462840 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.