Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | activin A receptor, type IB | Starlite/ChEMBL | References |
Homo sapiens | mitogen-activated protein kinase 14 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.1092 | 0.5 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.0192 | 0.1756 | 1 |
Schistosoma mansoni | protein kinase | 0.0192 | 0.1756 | 0.5 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.0192 | 0.1756 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.1092 | 0.6219 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.1092 | 0.6219 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0152 | 0.1092 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0676 | 0.9843 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.1092 | 0.6219 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0676 | 0.9843 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0152 | 0.1092 | 0.6219 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.0191 | 0.1742 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.1092 | 0.5 |
Echinococcus granulosus | TGF beta receptor type 1 | 0.0192 | 0.1756 | 1 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0685 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0685 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0152 | 0.1092 | 0.6219 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.1092 | 0.6219 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0676 | 0.9843 | 1 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0458 | 0.6196 | 0.4101 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0152 | 0.1092 | 0.5 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0191 | 0.1742 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0626 uM | Inhibition of human recombinant p38alpha MAPK expressed in Escherichia coli by radioisotopic protein kinase assay | ChEMBL. | 18571921 |
IC50 (binding) | > 1 uM | Inhibition of GST fused human recombinant ALK5 expressed in Sf9 cells by radioisotopic protein kinase assay | ChEMBL. | 18571921 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.