Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0041 | 0.0198 | 0.9972 |
Schistosoma mansoni | ran | 0.0023 | 0.006 | 0.0229 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0041 | 0.0198 | 0.0992 |
Treponema pallidum | penicillin-binding protein (pbp-1) | 0.0752 | 0.59 | 0.0472 |
Mycobacterium tuberculosis | Probable penicillin-binding membrane protein PbpB | 0.025 | 0.1878 | 0.1743 |
Mycobacterium leprae | conserved hypothetical protein | 0.0198 | 0.1458 | 0.2106 |
Mycobacterium ulcerans | hypothetical protein | 0.0198 | 0.1458 | 0.1949 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0198 | 0.099 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0491 | 0.3807 | 0.3704 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0198 | 0.1458 | 0.1316 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0198 | 0.1458 | 0.1316 |
Schistosoma mansoni | ran | 0.0023 | 0.006 | 0.0229 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0198 | 0.1458 | 0.1949 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0041 | 0.0198 | 0.0992 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0491 | 0.3807 | 0.5583 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0127 | 0.0479 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.075 | 0.588 | 0.879 |
Brugia malayi | Importin beta-1 subunit | 0.0032 | 0.0127 | 0.0869 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQF | 0.007 | 0.0434 | 0.0439 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0041 | 0.0198 | 0.0766 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0196 | 0.1444 | 0.1302 |
Loa Loa (eye worm) | inositol-1 | 0.0041 | 0.0198 | 0.0767 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0041 | 0.0198 | 0.0766 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0041 | 0.0198 | 0.0766 |
Echinococcus multilocularis | lamin | 0.003 | 0.011 | 0.0425 |
Mycobacterium tuberculosis | Conserved protein | 0.0198 | 0.1458 | 0.1316 |
Plasmodium falciparum | importin beta, putative | 0.0032 | 0.0127 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.1458 | 0.5644 |
Schistosoma mansoni | hypothetical protein | 0.0338 | 0.2583 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0032 | 0.0127 | 0.0489 |
Brugia malayi | beta-lactamase family protein | 0.0198 | 0.1458 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0198 | 0.099 |
Echinococcus granulosus | lamin | 0.003 | 0.011 | 0.0425 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0198 | 0.1458 | 0.1316 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0023 | 0.006 | 0.0231 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0041 | 0.0198 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0127 | 0.0479 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0198 | 0.1458 | 0.1316 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0041 | 0.0198 | 0.0222 |
Brugia malayi | intermediate filament protein | 0.003 | 0.011 | 0.0756 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.011 | 0.0427 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0 | 0.0002 |
Mycobacterium ulcerans | multidrug-transport integral membrane protein Mmr | 0.0213 | 0.1583 | 0.2142 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0041 | 0.0198 | 0.0766 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0023 | 0.006 | 0.0229 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.011 | 0.0427 |
Mycobacterium ulcerans | multidrugs-transport integral membrane protein Mmr-like | 0.0847 | 0.6662 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0198 | 0.1458 | 0.1316 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0041 | 0.0198 | 0.0765 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE | 0.0803 | 0.6309 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0198 | 0.1458 | 0.5643 |
Brugia malayi | beta-lactamase family protein | 0.0198 | 0.1458 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0041 | 0.0198 | 0.0221 |
Chlamydia trachomatis | transglycolase/transpeptidase | 0.0752 | 0.59 | 1 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0041 | 0.0198 | 0.0222 |
Mycobacterium ulcerans | lipoprotein LpqF | 0.007 | 0.0434 | 0.0365 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0198 | 0.1458 | 1 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0041 | 0.0198 | 0.0766 |
Onchocerca volvulus | 0.0198 | 0.1458 | 1 | |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0081 | 0.0521 | 0.2016 |
Mycobacterium leprae | Probable penicillin-binding membrane protein PbpB | 0.025 | 0.1878 | 0.2789 |
Schistosoma mansoni | lamin | 0.003 | 0.011 | 0.0425 |
Echinococcus multilocularis | snurportin 1 | 0.0338 | 0.2583 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.1365 | 0.5283 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.1458 | 0.5644 |
Mycobacterium ulcerans | class a beta-lactamase, BlaC | 0.0146 | 0.1041 | 0.1305 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0041 | 0.0198 | 0.1361 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0198 | 0.099 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0198 | 0.1458 | 0.5644 |
Loa Loa (eye worm) | beta-lactamase | 0.0198 | 0.1458 | 0.5644 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0198 | 0.1458 | 0.2237 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0198 | 0.1458 | 0.5643 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0041 | 0.0198 | 0.0992 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.011 | 0.0425 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.0198 | 0.0221 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0198 | 0.1458 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.011 | 0.0425 |
Echinococcus granulosus | importin subunit beta 1 | 0.0032 | 0.0127 | 0.0489 |
Schistosoma mansoni | lamin | 0.003 | 0.011 | 0.0425 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.1458 | 0.5644 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0041 | 0.0198 | 0.0766 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0023 | 0.006 | 0.0229 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0198 | 0.1458 | 0.5643 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0803 | 0.6309 | 1 |
Trichomonas vaginalis | importin beta-1, putative | 0.0026 | 0.0079 | 0.003 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0198 | 0.1458 | 0.5643 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0041 | 0.0198 | 0.0765 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0198 | 0.1458 | 0.2237 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0081 | 0.0521 | 0.2016 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.011 | 0.0425 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0338 | 0.2583 | 1 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0491 | 0.3807 | 0.5929 |
Treponema pallidum | penicillin-binding protein (pbp-2) | 0.0803 | 0.6309 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0.0079 | 0.137 |
Leishmania major | hypothetical protein, conserved | 0.0198 | 0.1458 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0106 | 0.041 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.0198 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.1458 | 0.5644 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0041 | 0.0198 | 0.099 |
Plasmodium vivax | hypothetical protein, conserved | 0.0198 | 0.1458 | 1 |
Brugia malayi | Inositol-1 | 0.0041 | 0.0198 | 0.1358 |
Onchocerca volvulus | 0.0198 | 0.1458 | 1 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0198 | 0.1458 | 0.2237 |
Echinococcus granulosus | snurportin 1 | 0.0338 | 0.2583 | 1 |
Trypanosoma brucei | beta lactamase | 0.007 | 0.0434 | 0.2675 |
Brugia malayi | RNA, U transporter 1 | 0.009 | 0.0595 | 0.408 |
Mycobacterium leprae | Probable lipase LipE | 0.0198 | 0.1458 | 0.2106 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0026 | 0.0079 | 0.0136 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqF | 0.007 | 0.0434 | 0.0274 |
Schistosoma mansoni | importin beta-1 | 0.0032 | 0.0127 | 0.0489 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.011 | 0.0756 |
Mycobacterium ulcerans | beta-lactamase | 0.0198 | 0.1458 | 0.1949 |
Leishmania major | importin beta-1 subunit, putative | 0.0026 | 0.0079 | 0.0136 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0079 | 0.003 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0041 | 0.0198 | 0.0766 |
Mycobacterium tuberculosis | Conserved protein | 0.0198 | 0.1458 | 0.1316 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0449 | 0.347 | 0.3361 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.1458 | 0.5644 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0127 | 0.049 |
Onchocerca volvulus | 0.0198 | 0.1458 | 1 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0198 | 0.1458 | 0.2237 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsI | 0.0752 | 0.59 | 1 |
Brugia malayi | beta-lactamase | 0.0198 | 0.1458 | 1 |
Echinococcus multilocularis | musashi | 0.003 | 0.011 | 0.0425 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0041 | 0.0198 | 1 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0196 | 0.1444 | 0.1928 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0198 | 0.0768 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0198 | 0.099 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0079 | 0.003 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0198 | 0.0765 |
Mycobacterium tuberculosis | Conserved protein | 0.0198 | 0.1458 | 0.1316 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0198 | 0.1458 | 0.2237 |
Mycobacterium tuberculosis | Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase | 0.0312 | 0.2375 | 0.2248 |
Echinococcus granulosus | geminin | 0.0186 | 0.1365 | 0.5283 |
Mycobacterium ulcerans | lipase LipD | 0.0198 | 0.1458 | 0.1949 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0023 | 0.006 | 0.0409 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.011 | 0.0427 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0449 | 0.347 | 0.5061 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.011 | 0.0425 |
Mycobacterium ulcerans | bifunctional penicillin-binding protein 1A/1B PonA1 | 0.0803 | 0.6309 | 0.9454 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0198 | 0.1458 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0032 | 0.0127 | 0.0479 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0198 | 0.1458 | 0.1316 |
Echinococcus multilocularis | geminin | 0.0186 | 0.1365 | 0.5283 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0198 | 0.1458 | 0.1316 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0198 | 0.1458 | 1 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0449 | 0.347 | 0.5379 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0196 | 0.1444 | 0.2083 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0041 | 0.0198 | 0.0766 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0032 | 0.0127 | 0.0479 |
Trichomonas vaginalis | esterase, putative | 0.0198 | 0.1458 | 0.2237 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0198 | 0.0222 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.1365 | 0.5283 |
Toxoplasma gondii | ABC1 family protein | 0.0198 | 0.1458 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0198 | 0.0765 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0041 | 0.0198 | 0.0992 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 0.1458 | 0.5644 |
Mycobacterium tuberculosis | Class a beta-lactamase BlaC | 0.0146 | 0.1041 | 0.0892 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0198 | 0.1458 | 0.1949 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.