Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | cysteine protease, putative | 0.1162 | 0.2113 | 0.4054 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.1162 | 0.2113 | 0.2113 |
Leishmania major | cathepsin L-like protease | 0.2161 | 0.5212 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Plasmodium vivax | vivapain-2 | 0.2161 | 0.5212 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.2161 | 0.5212 | 1 |
Plasmodium vivax | vivapain-2 | 0.2161 | 0.5212 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1478 | 0.3093 | 0.3093 |
Entamoeba histolytica | cysteine proteinase, putative | 0.2161 | 0.5212 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.148 | 0.3099 | 0.5946 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2161 | 0.5212 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.1162 | 0.2113 | 0.4054 |
Giardia lamblia | Cathepsin B precursor | 0.1478 | 0.3093 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Leishmania major | cathepsin L-like protease | 0.2161 | 0.5212 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3705 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1162 | 0.2113 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1162 | 0.2113 | 0.4054 |
Entamoeba histolytica | cysteine protease, putative | 0.1162 | 0.2113 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.2161 | 0.5212 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.1162 | 0.2113 | 0.4054 |
Onchocerca volvulus | 0.2161 | 0.5212 | 1 | |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0681 | 0.0624 | 0.0624 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2161 | 0.5212 | 0.5212 |
Echinococcus granulosus | cathepsin b | 0.3705 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.1478 | 0.3093 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.2161 | 0.5212 | 0.5212 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.148 | 0.3099 | 0.5946 |
Onchocerca volvulus | Cathepsin L homolog | 0.2161 | 0.5212 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0681 | 0.0624 | 0.0624 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Echinococcus multilocularis | cathepsin b | 0.3705 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.3705 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.2161 | 0.5212 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2161 | 0.5212 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0604 | 0.0383 | 0.0383 |
Schistosoma mansoni | cathepsin s | 0.0681 | 0.0624 | 0.0624 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.2161 | 0.5212 | 0.5212 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0564 | 0.026 | 0.0499 |
Brugia malayi | Cathepsin L-like precursor | 0.148 | 0.3099 | 0.3099 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.2161 | 0.5212 | 0.5212 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.2161 | 0.5212 | 0.5212 |
Plasmodium vivax | unspecified product | 0.1162 | 0.2113 | 0.4054 |
Echinococcus granulosus | cysteine protease | 0.1162 | 0.2113 | 0.2113 |
Onchocerca volvulus | 0.2161 | 0.5212 | 1 | |
Trypanosoma cruzi | cysteine proteinase, putative | 0.1162 | 0.2113 | 0.2113 |
Brugia malayi | Cathepsin L-like precursor | 0.148 | 0.3099 | 0.3099 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.148 | 0.3099 | 0.3099 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0681 | 0.0624 | 0.0624 |
Brugia malayi | Papain family cysteine protease containing protein | 0.2161 | 0.5212 | 0.5212 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.2161 | 0.5212 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.1162 | 0.2113 | 0.2113 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.1162 | 0.2113 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2161 | 0.5212 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.148 | 0.3099 | 0.3099 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.1162 | 0.2113 | 0.2113 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.1162 | 0.2113 | 0.4054 |
Leishmania major | cathepsin L-like protease | 0.2161 | 0.5212 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.1162 | 0.2113 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.148 | 0.3099 | 0.3099 |
Entamoeba histolytica | cysteine proteinase, putative | 0.148 | 0.3099 | 0.5946 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.2161 | 0.5212 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.1162 | 0.2113 | 0.4054 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0604 | 0.0383 | 0.0383 |
Onchocerca volvulus | Cathepsin L homolog | 0.2161 | 0.5212 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.2161 | 0.5212 | 0.5212 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0564 | 0.026 | 0.0499 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.1478 | 0.3093 | 0.5934 |
Echinococcus granulosus | cathepsin l1 | 0.148 | 0.3099 | 0.3099 |
Loa Loa (eye worm) | hypothetical protein | 0.0681 | 0.0624 | 0.0624 |
Plasmodium vivax | vivapain-1 | 0.1162 | 0.2113 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.3705 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.2161 | 0.5212 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.2161 | 0.5212 | 0.5212 |
Entamoeba histolytica | cysteine protease, putative | 0.1162 | 0.2113 | 0.4054 |
Loa Loa (eye worm) | cysteine protease | 0.2161 | 0.5212 | 0.5212 |
Loa Loa (eye worm) | cathepsin B | 0.1478 | 0.3093 | 0.3093 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.2161 | 0.5212 | 0.5212 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.148 | 0.3099 | 0.3099 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.1162 | 0.2113 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1162 | 0.2113 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.2161 | 0.5212 | 0.5212 |
Loa Loa (eye worm) | hypothetical protein | 0.148 | 0.3099 | 0.3099 |
Brugia malayi | Cathepsin L-like precursor | 0.2161 | 0.5212 | 0.5212 |
Brugia malayi | Cathepsin L-like precursor | 0.2161 | 0.5212 | 0.5212 |
Brugia malayi | Cathepsin L-like precursor | 0.0681 | 0.0624 | 0.0624 |
Leishmania major | cathepsin L-like protease | 0.2161 | 0.5212 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0659 | 0.0555 | 0.0555 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2161 | 0.5212 | 0.5212 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1162 | 0.2113 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2161 | 0.5212 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2161 | 0.5212 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.1162 | 0.2113 | 0.4054 |
Onchocerca volvulus | 0.148 | 0.3099 | 0.5946 | |
Onchocerca volvulus | 0.2161 | 0.5212 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2161 | 0.5212 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0681 | 0.0624 | 0.0624 |
Onchocerca volvulus | 0.2161 | 0.5212 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3705 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.2161 | 0.5212 | 1 |
Echinococcus multilocularis | cathepsin b | 0.3705 | 1 | 1 |
Echinococcus granulosus | cathepsin L | 0.1162 | 0.2113 | 0.2113 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1478 | 0.3093 | 0.3093 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.1162 | 0.2113 | 0.2113 |
Loa Loa (eye worm) | hypothetical protein | 0.0681 | 0.0624 | 0.0624 |
Onchocerca volvulus | 0.2161 | 0.5212 | 1 | |
Entamoeba histolytica | cysteine proteinase 2 | 0.1162 | 0.2113 | 0.4054 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.2161 | 0.5212 | 1 |
Loa Loa (eye worm) | fibroinase | 0.2161 | 0.5212 | 0.5212 |
Brugia malayi | Cathepsin L-like precursor | 0.2161 | 0.5212 | 0.5212 |
Onchocerca volvulus | Cathepsin F homolog | 0.2161 | 0.5212 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.148 | 0.3099 | 0.3099 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.1162 | 0.2113 | 0.2113 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0604 | 0.0383 | 0.0383 |
Brugia malayi | Cathepsin L-like precursor | 0.2161 | 0.5212 | 0.5212 |
Entamoeba histolytica | cysteine protease, putative | 0.2161 | 0.5212 | 1 |
Echinococcus multilocularis | cathepsin L | 0.1162 | 0.2113 | 0.2113 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0681 | 0.0624 | 0.0624 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0524 | 0.0136 | 0.0136 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2161 | 0.5212 | 0.5212 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2161 | 0.5212 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.2161 | 0.5212 | 0.5212 |
Toxoplasma gondii | cathepsin B | 0.1478 | 0.3093 | 0.5934 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.2161 | 0.5212 | 0.5212 |
Entamoeba histolytica | cysteine protease, putative | 0.1162 | 0.2113 | 0.4054 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0659 | 0.0555 | 0.0555 |
Entamoeba histolytica | cysteine protease, putative | 0.1162 | 0.2113 | 0.4054 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.1478 | 0.3093 | 0.3162 |
Brugia malayi | Cathepsin L-like precursor | 0.2161 | 0.5212 | 0.5212 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.2161 | 0.5212 | 0.5212 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Plasmodium vivax | unspecified product | 0.0681 | 0.0624 | 0.1198 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.2161 | 0.5212 | 0.5212 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2161 | 0.5212 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.1162 | 0.2113 | 0.4054 |
Echinococcus multilocularis | cysteine protease | 0.2161 | 0.5212 | 0.5212 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0681 | 0.0624 | 0.0624 |
Onchocerca volvulus | 0.2161 | 0.5212 | 1 | |
Echinococcus multilocularis | cysteine protease | 0.2161 | 0.5212 | 0.5212 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.3705 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.148 | 0.3099 | 0.3099 |
Entamoeba histolytica | cysteine protease, putative | 0.1162 | 0.2113 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2161 | 0.5212 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0604 | 0.0383 | 0.0383 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.2161 | 0.5212 | 0.5212 |
Trypanosoma cruzi | cysteine protease, putative | 0.1162 | 0.2113 | 0.2113 |
Echinococcus granulosus | cathepsin l1 | 0.2161 | 0.5212 | 0.5212 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.2161 | 0.5212 | 0.5212 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1162 | 0.2113 | 0.2113 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Plasmodium vivax | vivapain-3 | 0.1162 | 0.2113 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.2161 | 0.5212 | 1 |
Leishmania major | cathepsin L-like protease | 0.2161 | 0.5212 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.3705 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3705 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2161 | 0.5212 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.2161 | 0.5212 | 0.5212 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.1478 | 0.3093 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.2161 | 0.5212 | 1 |
Onchocerca volvulus | 0.2161 | 0.5212 | 1 | |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.1162 | 0.2113 | 0.2113 |
Brugia malayi | Papain family cysteine protease containing protein | 0.1162 | 0.2113 | 0.2113 |
Entamoeba histolytica | cysteine proteinase, putative | 0.1162 | 0.2113 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.2161 | 0.5212 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.1162 | 0.2113 | 0.2113 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.1162 | 0.2113 | 0.4054 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1.76 ug ml-1 | Cytotoxicity against human SKOV3 cells | ChEMBL. | 18990572 |
EC50 (functional) | = 2.84 ug ml-1 | Cytotoxicity against human SK-MEL-2 cells | ChEMBL. | 18990572 |
EC50 (functional) | = 2.96 ug ml-1 | Cytotoxicity against human XF498 cells | ChEMBL. | 18990572 |
EC50 (functional) | = 4.15 ug ml-1 | Cytotoxicity against human A549 cells | ChEMBL. | 18990572 |
EC50 (functional) | = 6.51 ug ml-1 | Cytotoxicity against human HCT15 cells | ChEMBL. | 18990572 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.