TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 368.334 | Formula: C15H11F3N4O2S
H donors: 3 H acceptors: 5 LogP: 2.49 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OCc1csc(n1)c1ccnc(n1)Nc1cc(O)cc(c1)C(F)(F)F
InChi: 1S/C15H11F3N4O2S/c16-15(17,18)8-3-9(5-11(24)4-8)21-14-19-2-1-12(22-14)13-20-10(6-23)7-25-13/h1-5,7,23-24H,6H2,(H,19,21,22)
InChiKey: CXXHIMHTNIDPAR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cyclin-dependent kinase 3	Starlite/ChEMBL	References
Homo sapiens	spleen tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	zeta-chain (TCR) associated protein kinase 70kDa	Starlite/ChEMBL	References
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08253 non-specific protein-tyrosine kinase [EC2.7.10.2], putative	Get druggable targets OG5_131855	All targets in OG5_131855
Echinococcus multilocularis	cyclin dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Leishmania donovani	cell division protein kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Neospora caninum	CMGC kinase, CDK family TgPK2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei gambiense	cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium vivax	protein kinase Crk2	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Leishmania infantum	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania mexicana	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania donovani	cdc2-related kinase 3, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05855 spleen tyrosine kinase, putative	Get druggable targets OG5_131855	All targets in OG5_131855
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Trypanosoma congolense	cdc2-related kinase 1, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	cell division protein kinase 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126712	All targets in OG5_126712
Giardia lamblia	Kinase, CMGC CDK	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase shark	Get druggable targets OG5_131855	All targets in OG5_131855
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium yoelii	cdc2-related kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Babesia bovis	cell division control protein 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania infantum	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania braziliensis	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_131855	All targets in OG5_131855
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_131855	All targets in OG5_131855
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Trypanosoma cruzi	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Giardia lamblia	Kinase, CMGC CDK	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium falciparum	protein kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma congolense	cdc2-related kinase 3, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Trypanosoma brucei	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania braziliensis	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Theileria parva	cell division control protein 2 related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium knowlesi	Cell division control protein 2 homolog	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Brugia malayi	cell division control protein 2 homolog	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Cryptosporidium parvum	Cdc2-like CDK2/CDC28 like protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Trypanosoma brucei	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	tyrosine protein kinase shark	Get druggable targets OG5_131855	All targets in OG5_131855
Trypanosoma cruzi	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K02087 cyclin-dependent kinase 1, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma japonicum	ko:K02090 cyclin-dependent kinase 5, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium berghei	cdc2-related kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	cyclin dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania mexicana	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	cell division protein kinase 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Cryptosporidium hominis	cdc2-like protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	cyclin dependent kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei gambiense	cell division related protein kinase 2, putative,CDC2-related protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	cyclin dependent kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Leishmania major	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	cyclin-dependent kinase 3	305 aa	303 aa	32.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	growth factor receptor bound protein 2	0.0021	0.0101	0.0086
Loa Loa (eye worm)	glutaminase 2	0.0267	0.4849	0.6434
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0065	0.0938	0.1229
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0027	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0356	0.0454
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0021	0.0101	0.0086
Brugia malayi	SH2 domain containing protein	0.0017	0.0015	0.002
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0017	0.0027	0.0012
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0061	0.087	0.0856
Mycobacterium tuberculosis	Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at)	0.0021	0.0101	0.0105
Echinococcus multilocularis	tyrosine kinase	0.0021	0.0105	0.009
Trypanosoma cruzi	cdc2-related kinase 3	0.0053	0.0723	0.7559
Echinococcus multilocularis	c src tyrosine kinase	0.0026	0.0191	0.0176
Brugia malayi	Tensin	0.0017	0.0015	0.002
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0017	0.0027	0.0036
Onchocerca volvulus		0.0021	0.0105	1
Brugia malayi	protein-tyrosine kinase	0.0057	0.0785	0.1042
Toxoplasma gondii	ornithine aminotransferase, mitochondrial precursor, putative	0.0021	0.0101	0.0219
Schistosoma mansoni	tyrosine kinase	0.0061	0.087	0.0856
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0123	0.2075	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0105	0.012
Onchocerca volvulus		0.0021	0.0105	1
Schistosoma mansoni	succinate semialdehyde dehydrogenase	0.0034	0.0356	0.0341
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0053	0.0723	0.3302
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0017	0.0027	0.0012
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0105	0.012
Mycobacterium ulcerans	carbon monoxyde dehydrogenase medium chain CoxM	0.0059	0.0824	0.16
Schistosoma mansoni	nuclear hormone receptor	0.0017	0.0027	0.0012
Giardia lamblia	Kinase, CMGC CDK	0.0053	0.0723	1
Mycobacterium ulcerans	carbon monoxyde dehydrogenase small chain CoxS	0.0033	0.0333	0.0576
Schistosoma mansoni	thyroid hormone receptor	0.0017	0.0027	0.0012
Entamoeba histolytica	protein kinase, putative	0.0406	0.7528	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0061	0.087	0.0856
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0017	0.0027	0.0012
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0017	0.0027	0.0016
Echinococcus granulosus	tyrosine protein kinase Srms	0.0021	0.0105	0.009
Brugia malayi	ecdysteroid receptor	0.0017	0.0027	0.0036
Brugia malayi	SH2 domain containing protein	0.0017	0.0015	0.002
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0061	0.087	0.0856
Brugia malayi	hypothetical protein	0.0021	0.0105	0.014
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0021	0.0101	0.0114
Mycobacterium ulcerans	acetylornithine aminotransferase	0.0021	0.0101	0.0092
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.0938	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0026	0.0191	0.0176
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0021	0.0101	0.0086
Mycobacterium ulcerans	carbon monoxyde dehydrogenase small chain CoxS	0.0033	0.0333	0.0576
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0027	0.0016
Onchocerca volvulus	Bile acid receptor homolog	0.0017	0.0027	0.1331
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0057	0.0785	0.0771
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0123	0.2075	0.4211
Brugia malayi	Variant SH3 domain containing protein	0.0017	0.0015	0.002
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0017	0.0027	0.0012
Giardia lamblia	Kinase, CMGC CDK	0.0053	0.0723	1
Mycobacterium ulcerans	carbon monoxide dehydrogenase	0.0115	0.1911	0.3869
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0021	0.0101	0.0114
Echinococcus granulosus	tyrosine protein kinase Blk	0.0057	0.0785	0.0771
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0061	0.087	0.0856
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0017	0.0027	0.0012
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0017	0.0027	0.0036
Echinococcus granulosus	ornithine aminotransferase	0.0021	0.0101	0.0086
Schistosoma mansoni	RAR-like nuclear receptor	0.0017	0.0027	0.0012
Trichomonas vaginalis	glutaminase, putative	0.0267	0.4849	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0018	0.005	0.0047
Mycobacterium ulcerans	aerobic-type carbon monoxide dehydrogenase subunit CoxM_2	0.0059	0.0824	0.16
Echinococcus granulosus	cyclin dependent kinase 5	0.0053	0.0723	0.0709
Schistosoma mansoni	growth factor receptor-bound protein	0.0021	0.0101	0.0086
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0072	0.1082	0.1069
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0026	0.0191	0.0176
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0105	0.014
Brugia malayi	photoreceptor-specific nuclear receptor	0.0017	0.0027	0.0036
Onchocerca volvulus		0.0017	0.0027	0.1331
Mycobacterium ulcerans	NAD-dependent aldehyde dehydrogenase AldA	0.0034	0.0356	0.0624
Mycobacterium ulcerans	carbon monoxyde dehydrogenase large chain CoxL	0.0082	0.1272	0.2535
Schistosoma mansoni	tyrosine kinase	0.0534	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0105	0.012
Treponema pallidum	quinoline 2-oxidoreductase	0.0028	0.0225	0.93
Schistosoma mansoni	retinoic acid receptor RXR	0.0017	0.0027	0.0012
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0053	0.0723	0.3302
Echinococcus multilocularis	ornithine aminotransferase	0.0021	0.0101	0.0086
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0065	0.0938	0.0925
Schistosoma mansoni	ap endonuclease	0.0019	0.0057	0.0042
Schistosoma mansoni	glutaminase	0.0267	0.4849	0.4841
Schistosoma mansoni	tyrosine kinase	0.0517	0.9676	0.9676
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0105	0.012
Treponema pallidum	hypothetical protein	0.0028	0.0238	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0061	0.087	0.0856
Schistosoma mansoni	growth factor receptor-bound protein	0.0021	0.0101	0.0086
Schistosoma mansoni	aldehyde dehydrogenase	0.0123	0.2075	0.2063
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0057	0.0056
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0021	0.0105	0.009
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0026	0.0191	0.0176
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0061	0.087	0.0856
Schistosoma mansoni	aldehyde dehydrogenase	0.0123	0.2075	0.2063
Mycobacterium ulcerans	glutamate-1-semialdehyde aminotransferase	0.0021	0.0101	0.0092
Schistosoma mansoni	serine/threonine protein kinase	0.0208	0.3715	0.3706
Plasmodium falciparum	protein kinase 5	0.0053	0.0723	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0061	0.087	0.0856
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0057	0.0785	0.0771
Echinococcus granulosus	c src tyrosine kinase	0.0026	0.0191	0.0176
Echinococcus multilocularis	cyclin dependent kinase 1	0.0053	0.0723	0.0709
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+])	0.0034	0.0356	0.071
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0027	0.0016
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0052	0.0694	0.068
Mycobacterium ulcerans	NAD-dependent aldehyde dehydrogenase AldA	0.0034	0.0356	0.0624
Leishmania major	aldehyde dehydrogenase, putative	0.0034	0.0356	0.1482
Echinococcus multilocularis	ornithine aminotransferase	0.0021	0.0101	0.0086
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0017	0.0027	0.0036
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0061	0.087	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0027	0.0016
Schistosoma mansoni	tyrosine kinase	0.0026	0.0191	0.0176
Entamoeba histolytica	protein kinase, putative	0.004	0.0463	0.0596
Plasmodium vivax	ornithine aminotransferase, putative	0.0021	0.0101	0.0664
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0017	0.0027	0.0012
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0053	0.0723	0.0709
Echinococcus granulosus	serine:threonine protein kinase:endoribonuclease	0.0406	0.7528	0.7524
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0065	0.0938	0.1229
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0065	0.0938	0.4369
Echinococcus granulosus	Aminotransferase class III	0.0021	0.0101	0.0086
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0017	0.0027	0.0016
Echinococcus multilocularis	Aminotransferase class III	0.0021	0.0101	0.0086
Trichomonas vaginalis	xanthine dehydrogenase, putative	0.0174	0.3041	0.6227
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0053	0.0723	0.0943
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0026	0.0191	0.0176
Mycobacterium leprae	PROBABLE SUCCINATE-SEMIALDEHYDE DEHYDROGENASE [NADP+] DEPENDENT (SSDH) GABD	0.0034	0.0356	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0017	0.0027	0.0012
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0061	0.087	0.0856
Echinococcus multilocularis	tyrosine protein kinase shark	0.0534	1	1
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0105	0.014
Brugia malayi	SH2 domain containing protein	0.0017	0.0015	0.002
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0021	0.0105	0.009
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0017	0.0027	0.0012
Echinococcus granulosus	tyrosine kinase	0.0057	0.0785	0.0771
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0017	0.0027	0.0012
Plasmodium vivax	protein kinase Crk2	0.0053	0.0723	1
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0065	0.0938	0.1247
Brugia malayi	SH2 domain containing protein	0.0017	0.0015	0.002
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0061	0.087	0.0856
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0021	0.0105	0.012
Brugia malayi	Variant SH3 domain containing protein	0.0021	0.0101	0.0134
Mycobacterium tuberculosis	Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)	0.0021	0.0101	0.0105
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.0021	0.0101	0.0092
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0017	0.0027	0.0036
Mycobacterium ulcerans	aerobic-type carbon monoxide dehydrogenase subunit CoxL_2	0.0082	0.1272	0.2535
Brugia malayi	RhoGAP domain containing protein	0.0017	0.0015	0.002
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0017	0.0015	0.002
Trypanosoma cruzi	cdc2-related kinase 3	0.0053	0.0723	0.7559
Schistosoma mansoni	tyrosine kinase	0.0061	0.087	0.0856
Mycobacterium ulcerans	succinate-semialdehyde dehydrogenase	0.0034	0.0356	0.0624
Loa Loa (eye worm)	TK protein kinase	0.004	0.0463	0.0596
Brugia malayi	SRC-1	0.0061	0.087	0.1156
Mycobacterium tuberculosis	Probable acetylornithine aminotransferase ArgD	0.0021	0.0101	0.0105
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0021	0.0101	0.0092
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0017	0.0027	0.0036
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0123	0.2075	0.4793
Brugia malayi	Variant SH3 domain containing protein	0.0021	0.0101	0.0134
Echinococcus granulosus	FTZ F1 alpha	0.0017	0.0027	0.0012
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0105	0.012
Brugia malayi	steroid hormone receptor	0.0017	0.0027	0.0036
Mycobacterium ulcerans	glutaminase	0.0267	0.4849	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0017	0.0027	0.0036
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0017	0.0027	0.0012
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0021	0.0105	0.009
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0723	0.0709
Trichomonas vaginalis	aldehyde oxidase, putative	0.0174	0.3041	0.6227
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0017	0.0027	0.0012
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0105	0.012
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0105	0.012
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0105	0.014
Brugia malayi	Tyrosine-protein kinase abl-1	0.0026	0.0191	0.0254
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0065	0.0938	0.0925
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0027	0.0016
Brugia malayi	SH2 domain containing protein	0.0021	0.0105	0.014
Schistosoma mansoni	adapter molecule crk	0.0021	0.0101	0.0086
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0017	0.0027	0.0016
Onchocerca volvulus	Protein ultraspiracle homolog	0.0017	0.0027	0.1331
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0017	0.0027	0.0012
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	0.0034	0.0356	0.071
Brugia malayi	SH2 domain containing protein	0.0017	0.0015	0.002
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0723	0.1391
Onchocerca volvulus		0.0021	0.0105	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0017	0.0027	0.0012
Entamoeba histolytica	cell division protein kinase 2, putative	0.0053	0.0723	0.0943
Trypanosoma brucei	aldehyde dehydrogenase, putative	0.0034	0.0356	0.3391
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0017	0.0027	0.0036
Echinococcus granulosus	ecdysone induced protein 78C	0.0017	0.0027	0.0012
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0057	0.0042
Mycobacterium tuberculosis	Probable aminotransferase	0.0021	0.0101	0.0105
Chlamydia trachomatis	glutamate-1-semialdehyde-2,1-aminomutase	0.0021	0.0101	0.5
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0017	0.0027	0.0012
Mycobacterium tuberculosis	Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase)	0.0237	0.4266	1
Trichomonas vaginalis	acetylornithine aminotransferase, putative	0.0021	0.0101	0.0092
Brugia malayi	SH2 domain containing protein	0.0017	0.0015	0.002
Echinococcus multilocularis	FTZ F1 alpha	0.0017	0.0027	0.0012
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0063	0.0905	0.0892
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0021	0.0101	0.0092
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0105	0.012
Loa Loa (eye worm)	steroid hormone receptor	0.0017	0.0027	0.0016
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0723	0.0709
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0017	0.0027	0.0012
Brugia malayi	Sex muscle abnormal protein 5	0.0021	0.0101	0.0134
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.0021	0.0101	0.0105
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0061	0.087	0.0856
Toxoplasma gondii	aldehyde dehydrogenase	0.0123	0.2075	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0017	0.0027	0.0012
Trichomonas vaginalis	conserved hypothetical protein	0.0207	0.368	0.7562
Echinococcus multilocularis	serine:threonine protein kinase:endoribonuclease	0.0406	0.7528	0.7524
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0021	0.0105	0.009
Brugia malayi	Steroid receptor seven-up type 2	0.0017	0.0027	0.0036
Trypanosoma brucei	cdc2-related kinase 3	0.0053	0.0723	0.7559
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0017	0.0027	0.0012
Echinococcus multilocularis	tyrosine protein kinase HCK	0.004	0.0463	0.0449
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0105	0.012
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0017	0.0027	0.0036
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0017	0.0027	0.0036
Brugia malayi	Variant SH3 domain containing protein	0.0017	0.0015	0.002
Loa Loa (eye worm)	glutaminase	0.0267	0.4849	0.6434
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.0414	0.04
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0053	0.0723	0.0943
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.0938	1
Echinococcus multilocularis	cyclin dependent kinase 5	0.0053	0.0723	0.0709
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (large chain)	0.0082	0.1272	0.2886
Loa Loa (eye worm)	TK protein kinase	0.0057	0.0785	0.1024
Wolbachia endosymbiont of Brugia malayi	acetylornithine transaminase protein	0.0021	0.0101	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0017	0.0015	0.002
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0017	0.0027	0.0012
Loa Loa (eye worm)	SRC-1	0.0061	0.087	0.1138
Brugia malayi	cell division control protein 2 homolog	0.0053	0.0723	0.0961
Entamoeba histolytica	protein kinase, putative	0.0018	0.005	0.0047
Schistosoma mansoni	tyrosine kinase	0.0021	0.0105	0.009
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0027	0.0016
Toxoplasma gondii	NADP-dependent succinate-semialdehyde dehydrogenase	0.0034	0.0356	0.1482
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0123	0.2075	0.2063
Brugia malayi	SH2 domain containing protein	0.0017	0.0015	0.002
Echinococcus multilocularis	cyclin dependent kinase	0.0053	0.0723	0.0709
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0123	0.2075	0.2063
Echinococcus granulosus	cyclin dependent kinase	0.0053	0.0723	0.0709
Schistosoma mansoni	nck2/grb4	0.0021	0.0101	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0027	0.0016
Brugia malayi	SH2 domain containing protein	0.0021	0.0105	0.014
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0057	0.0076
Mycobacterium ulcerans	hypothetical protein	0.0028	0.0238	0.0377
Mycobacterium ulcerans	carbon monoxyde dehydrogenase large chain CoxL	0.0051	0.0686	0.1312
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0072	0.1082	0.1069
Onchocerca volvulus		0.0021	0.0105	1
Echinococcus multilocularis	NCK adaptor protein	0.0021	0.0101	0.0086
Echinococcus multilocularis	cyclin dependent kinase 1	0.0053	0.0723	0.0709
Brugia malayi	4-aminobutyrate aminotransferase, mitochondrial precursor	0.0237	0.4266	0.5668
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0017	0.0027	0.1331
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0017	0.0027	0.0016
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0017	0.0027	0.0036
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0105	0.014
Schistosoma mansoni	tyrosine kinase	0.0026	0.0191	0.0176
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0105	0.014
Mycobacterium ulcerans	ornithine aminotransferase RocD1 and RocD2	0.0021	0.0101	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0101	0.0114
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0017	0.0027	0.0012
Echinococcus multilocularis	succinate semialdehyde dehydrogenase	0.0034	0.0356	0.0341
Echinococcus granulosus	tyrosine protein kinase HCK	0.004	0.0463	0.0449
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0061	0.087	0.0856
Echinococcus granulosus	tyrosine kinase	0.0021	0.0105	0.009
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0053	0.0723	0.3302
Brugia malayi	Succinate semialdehyde dehydrogenase, mitochondrial precursor	0.0034	0.0356	0.0473
Schistosoma mansoni	ap endonuclease	0.0019	0.0057	0.0042
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0017	0.0027	0.0036
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0052	0.0694	0.068
Entamoeba histolytica	protein kinase, putative	0.0406	0.7528	1
Entamoeba histolytica	cell division protein kinase 2, putative	0.0053	0.0723	0.0943
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0053	0.0723	0.0943
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0017	0.0027	0.0012
Mycobacterium ulcerans	hypothetical protein	0.0021	0.0101	0.0092
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0017	0.0015	0.002
Onchocerca volvulus		0.0021	0.0105	1
Brugia malayi	nuclear hormone receptor	0.0017	0.0027	0.0036
Echinococcus multilocularis	ecdysone induced protein 78C	0.0017	0.0027	0.0012
Echinococcus multilocularis	succinate semialdehyde dehydrogenase	0.0034	0.0356	0.0341
Mycobacterium ulcerans	L-lysine aminotransferase	0.0237	0.4266	0.8785
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0057	0.0785	0.0771
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0105	0.012
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.0938	1
Trypanosoma cruzi	cdc2-related kinase 1	0.0053	0.0723	0.7559
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0123	0.2075	0.4211
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0017	0.0027	0.0016
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0123	0.2075	0.4211
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0723	0.1391
Schistosoma mansoni	coup transcription factor	0.0017	0.0027	0.0012
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0017	0.0027	0.0012
Trichomonas vaginalis	serine threonine-protein kinase, putative	0.0207	0.368	0.7562
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0057	0.0785	0.0771
Brugia malayi	nuclear receptor NHR-88	0.0017	0.0027	0.0036
Schistosoma mansoni	thyroid hormone receptor	0.0017	0.0027	0.0012
Echinococcus granulosus	NCK adaptor protein	0.0021	0.0101	0.0086
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0057	0.0042
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0017	0.0027	0.0016
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (small chain)	0.0033	0.0333	0.0655
Brugia malayi	hypothetical protein	0.0017	0.0015	0.002
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0356	0.0454
Schistosoma mansoni	ornithine--oxo-acid transaminase	0.0021	0.0101	0.0086
Brugia malayi	Protein kinase domain containing protein	0.0053	0.0723	0.0961
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0688	0.0896
Treponema pallidum	hypothetical protein	0.0023	0.0142	0.4689
Brugia malayi	Ribonuclease 2-5A family protein	0.0406	0.7528	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0061	0.087	0.0856
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0057	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0105	0.012
Trypanosoma cruzi	cdc2-related kinase 1	0.0053	0.0723	0.7559
Brugia malayi	glutaminase DH11.1	0.0267	0.4849	0.6441
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0061	0.087	0.0856
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0061	0.087	0.0856
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0723	0.1391
Trypanosoma cruzi	aldehyde dehydrogenase, putative	0.0034	0.0356	0.3391
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0017	0.0027	0.0036
Echinococcus granulosus	succinate semialdehyde dehydrogenase	0.0034	0.0356	0.0341
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0017	0.0015	0.002
Loa Loa (eye worm)	IRE protein kinase	0.0406	0.7528	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0021	0.0105	0.012
Onchocerca volvulus		0.0021	0.0105	1
Mycobacterium tuberculosis	Probable carbon monoxyde dehydrogenase (medium chain)	0.0059	0.0824	0.1822
Echinococcus granulosus	cyclin dependent kinase 1	0.0053	0.0723	0.0709
Trypanosoma brucei	cdc2-related kinase 1	0.0053	0.0723	0.7559
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0017	0.0027	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0027	0.0016
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0065	0.0938	0.0925
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0017	0.0027	0.0016
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0061	0.087	0.0856
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.0414	0.04
Trichomonas vaginalis	xanthine dehydrogenase, putative	0.0174	0.3041	0.6227
Plasmodium falciparum	ornithine aminotransferase	0.0021	0.0101	0.0664
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0017	0.0027	0.0036

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.09 uM	Inhibition of SYK-mediated FCepsilonRI signaling activity by mast cell degranulation assay	ChEMBL.	18938080
Ki (binding)	= 0.05 uM	Inhibition of SYK	ChEMBL.	18938080
Ki (binding)	= 0.68 uM	Inhibition of ZAP70	ChEMBL.	18938080
Ki (binding)	= 1.5 uM	Inhibition of CDK2	ChEMBL.	18938080
Ki (binding)	= 4 uM	Inhibition of SRC	ChEMBL.	18938080

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL485730

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 986957