Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | dynamin-1-like protein, putative | 0.00578919 | 0.811199 | 0.5 |
Trypanosoma cruzi | dynamin-1-like protein | 0.00578919 | 0.811199 | 0.5 |
Echinococcus granulosus | dynamin 1 | 0.00623214 | 1 | 1 |
Trichomonas vaginalis | dynamin, putative | 0.00578919 | 0.811199 | 0.5 |
Trichomonas vaginalis | dynamin, putative | 0.00578919 | 0.811199 | 0.5 |
Trichomonas vaginalis | dynamin, putative | 0.00578919 | 0.811199 | 0.5 |
Trichomonas vaginalis | dynamin, putative | 0.00578919 | 0.811199 | 0.5 |
Schistosoma mansoni | dynamin | 0.00623214 | 1 | 1 |
Plasmodium vivax | dynamin protein, putative | 0.00578919 | 0.811199 | 0.5 |
Plasmodium falciparum | dynamin-like protein | 0.00578919 | 0.811199 | 0.5 |
Trichomonas vaginalis | interferon-induced GTP-binding protein mx, putative | 0.00578919 | 0.811199 | 0.5 |
Trichomonas vaginalis | dynamin, putative | 0.00578919 | 0.811199 | 0.5 |
Plasmodium falciparum | dynamin-like protein | 0.00578919 | 0.811199 | 0.5 |
Trichomonas vaginalis | dynamin, putative | 0.00578919 | 0.811199 | 0.5 |
Brugia malayi | Dynamin | 0.00623214 | 1 | 1 |
Leishmania major | GTP-binding protein, putative | 0.00578919 | 0.811199 | 0.5 |
Schistosoma mansoni | dynamin | 0.00623214 | 1 | 1 |
Trichomonas vaginalis | mgm1, putative | 0.00578919 | 0.811199 | 0.5 |
Toxoplasma gondii | dynamin-related protein DRPA | 0.00578919 | 0.811199 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00623214 | 1 | 1 |
Trypanosoma brucei | dynamin-1-like protein | 0.00578919 | 0.811199 | 0.5 |
Giardia lamblia | Dynamin | 0.00578919 | 0.811199 | 0.5 |
Brugia malayi | Dynamin | 0.00623214 | 1 | 1 |
Echinococcus multilocularis | dynamin 1 | 0.00623214 | 1 | 1 |
Plasmodium vivax | dynamin-like protein, putative | 0.00578919 | 0.811199 | 0.5 |
Toxoplasma gondii | dynamin-related protein DRPB | 0.00578919 | 0.811199 | 1 |
Entamoeba histolytica | dynamin-like protein | 0.00578919 | 0.811199 | 0.5 |
Trypanosoma brucei | dynamin-1-like protein | 0.00578919 | 0.811199 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.79 ug ml-1 | Antiplasmodial activity against Plasmodium falciparum NF54 in human erythrocytes by [3H]hypoxanthine uptake | ChEMBL. | 11087584 |
IC50 (functional) | = 2.03 ug ml-1 | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 by Alamar blue assay | ChEMBL. | 11087584 |
IC50 (functional) | = 10 ug ml-1 | Antileishmanial activity against Leishmania donovani MHOM-ET-67/L82 amastigotes in mouse peritoneal macrophages | ChEMBL. | 11087584 |
IC50 (functional) | = 17.6 ug ml-1 | Antitrypanosomal activity against galactosidase gene containing Trypanosoma cruzi Tulahuen C2C4 trypomastigotes in rat L6 cells after 4 days | ChEMBL. | 11087584 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Leishmania donovani | ChEMBL23 | 11087584 | |
Trypanosoma brucei gambiense | 11087584 | ||
Plasmodium falciparum | ChEMBL23 | 11087584 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.