Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0082 | 0.0526 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0082 | 0.0526 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0076 | 0.0385 | 0.0436 |
Trypanosoma brucei | glucosidase, putative | 0.0082 | 0.0526 | 0.9586 |
Schistosoma mansoni | alpha-glucosidase | 0.0465 | 0.8827 | 1 |
Trypanosoma cruzi | lysosomal alpha-mannosidase precursor, putative | 0.0083 | 0.0547 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.2234 | 0.2234 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0082 | 0.0526 | 0.0489 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0187 | 0.0187 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0519 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha mannosidase | 0.0083 | 0.0547 | 0.0587 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6127 | 0.6112 |
Onchocerca volvulus | 0.0083 | 0.0548 | 0.0653 | |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0243 | 0.4023 | 0.4319 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0385 | 0.0385 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0519 | 1 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0082 | 0.0526 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6127 | 0.6112 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0076 | 0.0385 | 0.0348 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0548 | 0.0548 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0082 | 0.0526 | 0.0489 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0243 | 0.4023 | 0.4557 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0519 | 1 | 1 |
Echinococcus granulosus | beta galactosidase | 0.0161 | 0.2234 | 0.2399 |
Schistosoma mansoni | alpha-glucosidase | 0.0465 | 0.8827 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6127 | 0.6112 |
Plasmodium falciparum | plasmepsin II | 0.0076 | 0.0385 | 1 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.0212 | 0.3349 | 0.3596 |
Trypanosoma brucei | lysosomal alpha-mannosidase precursor, putative | 0.0083 | 0.0547 | 1 |
Giardia lamblia | Ceramide glucosyltransferase | 0.011 | 0.1134 | 0.5 |
Trypanosoma brucei | lysosomal alpha-mannosidase precursor, putative | 0.007 | 0.0248 | 0.4111 |
Schistosoma mansoni | beta-galactosidase | 0.0161 | 0.2234 | 0.2531 |
Schistosoma mansoni | alpha glucosidase | 0.0082 | 0.0526 | 0.0595 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.034 | 0.6127 | 0.7804 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.4654 | 0.4654 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0082 | 0.0526 | 0.0489 |
Trypanosoma cruzi | lysosomal alpha-mannosidase precursor, putative | 0.0083 | 0.0547 | 1 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0076 | 0.0385 | 0.0414 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0082 | 0.0526 | 0.0489 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0519 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0359 | 0.6525 | 0.6512 |
Onchocerca volvulus | 0.0419 | 0.784 | 1 | |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0082 | 0.0526 | 0.0489 |
Echinococcus granulosus | lysosomal alpha mannosidase | 0.0083 | 0.0547 | 0.0587 |
Echinococcus granulosus | L aminoadipate semialdehyde | 0.0083 | 0.0548 | 0.0588 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0082 | 0.0526 | 0.9586 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0082 | 0.0526 | 0.0489 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0082 | 0.0526 | 0.0564 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0076 | 0.0385 | 0.0414 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.0212 | 0.3349 | 0.3596 |
Echinococcus granulosus | bile acid beta glucosidase | 0.0212 | 0.3349 | 0.3596 |
Echinococcus multilocularis | L aminoadipate semialdehyde | 0.0083 | 0.0548 | 0.0588 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0082 | 0.0526 | 0.0489 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0243 | 0.4023 | 0.4557 |
Plasmodium vivax | plasmepsin IV, putative | 0.0076 | 0.0385 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0082 | 0.0526 | 0.9586 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0039 | 0.0039 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0487 | 0.9314 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6127 | 0.6112 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0487 | 0.9314 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0212 | 0.3349 | 0.3794 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.0212 | 0.3349 | 0.3596 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.1851 | 0.1851 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0519 | 1 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.0212 | 0.3349 | 0.3794 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0082 | 0.0526 | 0.0489 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0082 | 0.0526 | 0.0526 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0487 | 0.9314 | 1 |
Plasmodium falciparum | plasmepsin I | 0.0076 | 0.0385 | 1 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0076 | 0.0385 | 0.0385 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0243 | 0.4023 | 0.5106 |
Brugia malayi | Ceramide glucosyltransferase | 0.0243 | 0.4023 | 0.4023 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0082 | 0.0526 | 0.0489 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0076 | 0.0385 | 0.0436 |
Brugia malayi | aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase | 0.0083 | 0.0548 | 0.0548 |
Plasmodium falciparum | plasmepsin IV | 0.0076 | 0.0385 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0487 | 0.9314 | 0.9314 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6127 | 0.6112 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0487 | 0.9314 | 0.9314 |
Schistosoma mansoni | aminoadipate-semialdehyde dehydrogenase | 0.0083 | 0.0548 | 0.0621 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.006 | 0.0039 | 0.0039 |
Echinococcus multilocularis | beta galactosidase | 0.0161 | 0.2234 | 0.2399 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0359 | 0.6525 | 0.6512 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6127 | 0.6112 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0076 | 0.0385 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0076 | 0.0385 | 0.0436 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0082 | 0.0526 | 0.0564 |
Plasmodium falciparum | plasmepsin VI | 0.0076 | 0.0385 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0082 | 0.0526 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0082 | 0.0526 | 0.0526 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.034 | 0.6127 | 0.6112 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0243 | 0.4023 | 0.4319 |
Schistosoma mansoni | lysosomal alpha-mannosidase (mannosidase alpha class 2b member 1) | 0.0083 | 0.0547 | 0.0619 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0243 | 0.4023 | 0.4023 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.