Detailed information for compound 994112
Basic information
Technical information
- Name: Unnamed compound
- MW: 505.481 | Formula: C29H30Cl2N4
-
H donors: 1
H acceptors: 1
LogP: 6.83
Rotable bonds: 8
Rule of 5 violations (Lipinski): 2 - SMILES: Clc1ccc(cc1)C(c1ccccc1)N1CCN(CC1)CCCNc1ccnc2c1ccc(c2)Cl
- InChi: 1S/C29H30Cl2N4/c30-24-9-7-23(8-10-24)29(22-5-2-1-3-6-22)35-19-17-34(18-20-35)16-4-14-32-27-13-15-33-28-21-25(31)11-12-26(27)28/h1-3,5-13,15,21,29H,4,14,16-20H2,(H,32,33)
- InChiKey: FYIHUHLFTBIBLG-UHFFFAOYSA-N
Network
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Synonyms
No synonyms found for this compound
Targets
Known targets for this compound
No curated genes were found associated with this compound
Predicted pathogen targets for this compound
By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Schistosoma mansoni | short chain dehydrogenase | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0088 | 1 | 1 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 13 homolog | 0.0088 | 1 | 0.5 |
| Mycobacterium leprae | Probable oxidoreductase | 0.0088 | 1 | 0.5 |
| Leishmania major | hypothetical protein, conserved | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | oxidoreductase | 0.0088 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 1 |
| Entamoeba histolytica | short chain dehydrogenase family protein | 0.0088 | 1 | 0.5 |
| Toxoplasma gondii | carbonyl reductase 1, putative | 0.0088 | 1 | 0.5 |
| Trypanosoma cruzi | short chain dehydrogenase/reductase, putative | 0.0088 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 1 |
| Leishmania major | pteridine reductase 1 | 0.0088 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0088 | 1 | 0.5 |
| Echinococcus granulosus | hypothetical protein | 0.0088 | 1 | 0.5 |
| Echinococcus multilocularis | retinol dehydrogenase 11 | 0.0088 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0088 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0088 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short chain alcohol dehydrogenase/reductase | 0.0088 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0088 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | short-chain membrane-associated dehydrogenase | 0.0088 | 1 | 1 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | oxidoreductase | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 1 |
| Echinococcus granulosus | retinol dehydrogenase 11 | 0.0088 | 1 | 0.5 |
| Onchocerca volvulus | 0.0088 | 1 | 0.5 | |
| Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0088 | 1 | 0.5 |
| Onchocerca volvulus | Sepiapterin reductase homolog | 0.0088 | 1 | 0.5 |
| Trypanosoma brucei | beta-ketoacyl-ACP reductase 3, putative | 0.0088 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0088 | 1 | 1 |
| Trypanosoma cruzi | NAD(P)-dependent oxidoreductase, putative | 0.0088 | 1 | 1 |
| Schistosoma mansoni | carbonyl reductase | 0.0088 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0088 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0088 | 1 | 0.5 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0088 | 1 | 1 |
| Echinococcus granulosus | WW domain containing oxidoreductase | 0.0088 | 1 | 0.5 |
| Trypanosoma cruzi | quinonoid dihydropteridine reductase, putative | 0.0088 | 1 | 1 |
| Trypanosoma brucei | 3-keto-dihydrosphingosine reductase | 0.0088 | 1 | 1 |
| Echinococcus granulosus | Dehydrogenase:reductase SDR family | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Onchocerca volvulus | 0.0088 | 1 | 0.5 | |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 0.5 |
| Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0088 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0088 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 1 |
| Loa Loa (eye worm) | short chain dehydrogenase/reductase family oxidoreductase | 0.0088 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 0.5 |
| Trypanosoma cruzi | 3-keto-dihydrosphingosine reductase | 0.0088 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0088 | 1 | 0.5 |
| Toxoplasma gondii | 3-ketoacyl-CoA reductase, putative | 0.0088 | 1 | 0.5 |
| Loa Loa (eye worm) | dehydrogenase | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Echinococcus multilocularis | conserved hypothetical protein | 0.0088 | 1 | 0.5 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0088 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0088 | 1 | 0.5 |
| Mycobacterium tuberculosis | Possible fatty acyl-CoA reductase | 0.0088 | 1 | 0.5 |
| Trypanosoma cruzi | beta-ketoacyl-ACP reductase 2, putative | 0.0088 | 1 | 1 |
| Brugia malayi | dehydrogenases, short chain protein 9 | 0.0088 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0088 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0088 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0088 | 1 | 0.5 |
| Brugia malayi | oxidoreductase | 0.0088 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, putative | 0.0088 | 1 | 0.5 |
| Leishmania major | short chain dehydrogenase-like protein | 0.0088 | 1 | 1 |
| Trypanosoma brucei | beta-ketoacyl-ACP reductase 2 | 0.0088 | 1 | 1 |
| Onchocerca volvulus | 0.0088 | 1 | 0.5 | |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0088 | 1 | 0.5 |
| Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type oxidoreductase | 0.0088 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 1 |
| Schistosoma mansoni | carbonyl reductase | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0088 | 1 | 0.5 |
| Trichomonas vaginalis | estradiol 17 beta-dehydrogenase, putative | 0.0088 | 1 | 0.5 |
| Leishmania major | 3-keto-dihydrosphingosine reductase | 0.0088 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0088 | 1 | 1 |
| Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0088 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0088 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0088 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0088 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0088 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0088 | 1 | 1 |
| Leishmania major | short chain dehydrogenase/reductase, putative | 0.0088 | 1 | 1 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0088 | 1 | 1 |
| Schistosoma mansoni | carbonyl reductase | 0.0088 | 1 | 0.5 |
| Giardia lamblia | Short-chain dehydrogenase, putative | 0.0088 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0088 | 1 | 0.5 |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0088 | 1 | 0.5 |
| Leishmania major | hypothetical protein, conserved | 0.0088 | 1 | 1 |
| Plasmodium vivax | hypothetical protein, conserved | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0088 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0088 | 1 | 0.5 |
| Onchocerca volvulus | 0.0088 | 1 | 0.5 | |
| Leishmania major | dehydrogenase-like protein | 0.0088 | 1 | 1 |
| Entamoeba histolytica | hypothetical protein | 0.0088 | 1 | 0.5 |
| Onchocerca volvulus | 0.0088 | 1 | 0.5 | |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0088 | 1 | 1 |
| Onchocerca volvulus | 0.0088 | 1 | 0.5 | |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0088 | 1 | 1 |
| Leishmania major | oxidoreductase-like protein | 0.0088 | 1 | 1 |
| Echinococcus granulosus | retinol dehydrogenase 11 | 0.0088 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0088 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0088 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain dehydrogenase/reductase | 0.0088 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0088 | 1 | 0.5 |
| Giardia lamblia | Oxidoreductase, short chain dehydrogenase/reductase family | 0.0088 | 1 | 0.5 |
| Plasmodium vivax | steroid dehydrogenase, putative | 0.0088 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0088 | 1 | 0.5 |
| Mycobacterium tuberculosis | Possible short-chain dehydrogenase EphD | 0.0088 | 1 | 0.5 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 0.5 |
| Mycobacterium leprae | Probable short-chain type dehydrogenase/reductase | 0.0088 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0088 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Brugia malayi | dehydrogenases, short chain protein 2 | 0.0088 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0088 | 1 | 1 |
| Echinococcus granulosus | 3 ketodihydrosphingosine reductase | 0.0088 | 1 | 0.5 |
| Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0088 | 1 | 1 |
| Trypanosoma cruzi | 3-ketoacyl-CoA reductase, putative | 0.0088 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0088 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0088 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0088 | 1 | 0.5 |
| Trypanosoma cruzi | beta-ketoacyl-ACP reductase 2, putative | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Entamoeba histolytica | 3-ketodihydrosphingosine reductase protein, putative | 0.0088 | 1 | 0.5 |
| Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0088 | 1 | 0.5 |
| Entamoeba histolytica | oxidoreductase, short chain dehydrogenase/reductase family | 0.0088 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable shortchain dehydrogenase | 0.0088 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0088 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenases/reductase, putative | 0.0088 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0088 | 1 | 0.5 |
| Mycobacterium tuberculosis | Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 | 0.0088 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0088 | 1 | 0.5 |
| Entamoeba histolytica | short chain dehydrogenase family protein | 0.0088 | 1 | 0.5 |
| Trypanosoma cruzi | short chain dehydrogenase/reductase, putative | 0.0088 | 1 | 1 |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0088 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0088 | 1 | 0.5 |
| Plasmodium falciparum | oxidoreductase, short-chain dehydrogenase family, putative | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0088 | 1 | 0.5 |
| Schistosoma mansoni | oxidoreductase short chain dehydrogenase/reductase family | 0.0088 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Leishmania major | short chain dehydrogenase, putative | 0.0088 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0088 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0088 | 1 | 1 |
| Echinococcus granulosus | hypothetical protein | 0.0088 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0088 | 1 | 0.5 |
| Leishmania major | short chain dehydrogenase/reductase, putative | 0.0088 | 1 | 1 |
| Echinococcus multilocularis | steroid dehydrogenase | 0.0088 | 1 | 0.5 |
| Brugia malayi | Cytochrome P450 family protein | 0.0035 | 0.1886 | 0.1886 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0088 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0088 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0088 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0088 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0088 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0088 | 1 | 1 |
| Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0088 | 1 | 0.5 |
| Echinococcus multilocularis | epidermal retinal dehydrogenase 2 | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0088 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0088 | 1 | 0.5 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0088 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0088 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Entamoeba histolytica | hypothetical protein, conserved | 0.0088 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0088 | 1 | 1 |
| Trypanosoma brucei | 3-ketoacyl-CoA reductase, putative | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 13 homolog | 0.0088 | 1 | 0.5 |
| Trypanosoma brucei | oxidoreductase-like protein | 0.0088 | 1 | 1 |
| Echinococcus multilocularis | transient receptor potential cation channel | 0.0088 | 1 | 0.5 |
| Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0088 | 1 | 1 |
| Onchocerca volvulus | 0.0088 | 1 | 0.5 | |
| Mycobacterium tuberculosis | Probable dehydrogenase | 0.0088 | 1 | 0.5 |
| Loa Loa (eye worm) | oxidoreductase | 0.0088 | 1 | 1 |
| Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0088 | 1 | 0.5 |
| Toxoplasma gondii | oxidoreductase, putative | 0.0088 | 1 | 0.5 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0088 | 1 | 1 |
| Schistosoma mansoni | short-chain dehydrogenase/reductase | 0.0088 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0088 | 1 | 0.5 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0088 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | dehydrogenase/decarboxylase protein | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Onchocerca volvulus | 0.0088 | 1 | 0.5 | |
| Trypanosoma cruzi | short-chain dehydrogenase, putative | 0.0088 | 1 | 1 |
| Echinococcus granulosus | oxidoreductase | 0.0088 | 1 | 0.5 |
| Entamoeba histolytica | hypothetical protein, conserved | 0.0088 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0088 | 1 | 0.5 |
| Loa Loa (eye worm) | oxidoreductase | 0.0088 | 1 | 1 |
| Mycobacterium tuberculosis | Possible oxidoreductase | 0.0088 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 1 |
| Echinococcus multilocularis | oxidoreductase | 0.0088 | 1 | 0.5 |
| Brugia malayi | Dehydrogenases, short chain protein 30 | 0.0088 | 1 | 1 |
| Mycobacterium tuberculosis | Decaprenylphosphoryl-D-2-keto erythro pentose reductase | 0.0088 | 1 | 0.5 |
| Trypanosoma brucei | beta-D-hydroxybutyrate dehydrogenase | 0.0088 | 1 | 1 |
| Mycobacterium leprae | ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE | 0.0088 | 1 | 0.5 |
| Plasmodium falciparum | steroid dehydrogenase, putative | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0088 | 1 | 1 |
| Brugia malayi | Hypothetical oxidoreductase F56D1.5 | 0.0088 | 1 | 1 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 1 homolog | 0.0088 | 1 | 0.5 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0088 | 1 | 1 |
| Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0088 | 1 | 0.5 |
| Trichomonas vaginalis | steroid dehydrogenase, putative | 0.0088 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | carveol-like dehydrogenase | 0.0088 | 1 | 1 |
| Echinococcus multilocularis | Dehydrogenase:reductase SDR family | 0.0088 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0088 | 1 | 1 |
| Onchocerca volvulus | 0.0088 | 1 | 0.5 | |
| Schistosoma mansoni | short chain dehydrogenase | 0.0088 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0088 | 1 | 0.5 |
| Schistosoma mansoni | retinal dehydrogenase | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0088 | 1 | 1 |
| Onchocerca volvulus | 0.0088 | 1 | 0.5 | |
| Onchocerca volvulus | 0.0088 | 1 | 0.5 | |
| Echinococcus multilocularis | retinol dehydrogenase 11 | 0.0088 | 1 | 0.5 |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0088 | 1 | 0.5 |
| Leishmania major | hypothetical protein, conserved | 0.0088 | 1 | 1 |
| Trypanosoma cruzi | 3-ketoacyl-CoA reductase, putative | 0.0088 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0088 | 1 | 1 |
| Loa Loa (eye worm) | cytochrome P450 family protein | 0.0035 | 0.1886 | 0.1886 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Echinococcus granulosus | steroid dehydrogenase | 0.0088 | 1 | 0.5 |
| Brugia malayi | Retinol dehydrogenase 12 | 0.0088 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0088 | 1 | 0.5 |
| Mycobacterium leprae | Possible short-chain dehydrogenase EphD | 0.0088 | 1 | 0.5 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0088 | 1 | 1 |
| Giardia lamblia | Reductase, putative | 0.0088 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 1 |
| Trypanosoma cruzi | short-chain dehydrogenase, putative | 0.0088 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0088 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0088 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0088 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 1 |
| Echinococcus multilocularis | steroid dehydrogenase | 0.0088 | 1 | 0.5 |
| Brugia malayi | hypothetical protein | 0.0088 | 1 | 1 |
| Trypanosoma cruzi | short chain dehydrogenase, putative | 0.0088 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0088 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Giardia lamblia | Hypothetical protein | 0.0088 | 1 | 0.5 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0088 | 1 | 1 |
| Brugia malayi | D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor | 0.0088 | 1 | 1 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0088 | 1 | 0.5 |
| Mycobacterium leprae | Probable short-chain type dehydrogenase/reductase | 0.0088 | 1 | 0.5 |
| Leishmania major | short chain dehydrogenase, putative | 0.0088 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0088 | 1 | 1 |
| Brugia malayi | Dehydrogenases, short chain protein 2 | 0.0088 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0088 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Loa Loa (eye worm) | dehydrogenase | 0.0088 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 1 |
| Mycobacterium tuberculosis | Possible oxidoreductase | 0.0088 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0088 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0088 | 1 | 0.5 |
| Onchocerca volvulus | 0.0088 | 1 | 0.5 | |
| Echinococcus granulosus | epidermal retinal dehydrogenase 2 | 0.0088 | 1 | 0.5 |
| Echinococcus multilocularis | estradiol 17 beta dehydrogenase 12 | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0088 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0088 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0088 | 1 | 0.5 |
| Mycobacterium leprae | PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE | 0.0088 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0088 | 1 | 1 |
| Wolbachia endosymbiont of Brugia malayi | Short-chain alcohol dehydrogenase family enzyme | 0.0088 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0088 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0088 | 1 | 0.5 |
| Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0088 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0088 | 1 | 1 |
| Echinococcus multilocularis | 3 ketodihydrosphingosine reductase | 0.0088 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | dehydrogenase | 0.0088 | 1 | 1 |
| Mycobacterium tuberculosis | Possible iron-regulated short-chain dehydrogenase/reductase | 0.0088 | 1 | 0.5 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0088 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0088 | 1 | 0.5 |
| Onchocerca volvulus | 0.0088 | 1 | 0.5 | |
| Trypanosoma cruzi | short chain dehydrogenase, putative | 0.0088 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0088 | 1 | 1 |
| Trichomonas vaginalis | hydroxyacyl dehydrogenase, putative | 0.0088 | 1 | 0.5 |
| Echinococcus multilocularis | retinol dehydrogenase 13 | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | dehydrogenase/reductase | 0.0088 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type oxidoreductase | 0.0088 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 1 |
| Schistosoma mansoni | 3-keto-dihydrosphingosine reductase | 0.0088 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0088 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0088 | 1 | 1 |
| Trypanosoma cruzi | 3-keto-dihydrosphingosine reductase | 0.0088 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0088 | 1 | 1 |
| Trypanosoma cruzi | NAD(P)-dependent oxidoreductase, putative | 0.0088 | 1 | 1 |
| Mycobacterium tuberculosis | Possible ketoacyl reductase | 0.0088 | 1 | 0.5 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| Ratio IC50 (functional) | = 3.2 | Ratio of compound IC50 to chloroquine IC50 for chloroquine-sensitive Plasmodium falciparum D6 | ChEMBL. | 20684562 |
| Ratio IC50 (functional) | = 3.5 | Ratio of compound IC50 to chloroquine IC50 for chloroquine-resistant Plasmodium falciparum Dd2 | ChEMBL. | 20684562 |
| Ratio IC50 (functional) | = 12 | Ratio of compound IC50 to chloroquine IC50 for chloroquine-resistant Plasmodium falciparum 7G8 | ChEMBL. | 20684562 |
Phenotypes
Whole-cell/tissue/organism interactions
We have no records of whole-cell/tissue assays done with this compound
What does this mean?
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL1254234
Bibliographic References
No literature references available for this target.
If you have references for this compound, please enter them in a user comment (below) or Contact us.