TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 286.372 | Formula: C16H22N4O
H donors: 1 H acceptors: 2 LogP: 3.79 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: N#CN1CCCCN1C(=O)C(C(C)C)Nc1ccccc1
InChi: 1S/C16H22N4O/c1-13(2)15(18-14-8-4-3-5-9-14)16(21)20-11-7-6-10-19(20)12-17/h3-5,8-9,13,15,18H,6-7,10-11H2,1-2H3
InChiKey: RSZBUQVRCRNXMR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin B	Starlite/ChEMBL	References
Homo sapiens	cathepsin L	Starlite/ChEMBL	References
Homo sapiens	cathepsin K	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Toxoplasma gondii	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin B-like cysteine proteinase	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin B-like protease (Precursor), related	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania donovani	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	Get druggable targets OG5_127800	All targets in OG5_127800
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cathepsin B	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin b	Get druggable targets OG5_127800	All targets in OG5_127800
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	SmCB2 peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Giardia lamblia	Cathepsin B precursor	Get druggable targets OG5_127800	All targets in OG5_127800
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01363 cathepsin B [EC3.4.22.1], putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	Get druggable targets OG5_127800	All targets in OG5_127800
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase C (CPC)	Get druggable targets OG5_127800	All targets in OG5_127800
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	Get druggable targets OG5_127800	All targets in OG5_127800
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin B-like cysteine proteinase precursor, putative	Get druggable targets OG5_127800	All targets in OG5_127800
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin L	333 aa	359 aa	30.1 %
Plasmodium falciparum	dipeptidyl aminopeptidase 1	cathepsin B	339 aa	368 aa	26.9 %
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin K	329 aa	349 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2727	0.8838
Echinococcus multilocularis	cysteine protease	0.0059	0.2727	0.2733
Leishmania major	cathepsin L-like protease	0.0059	0.2727	0.8557
Onchocerca volvulus		0.0059	0.2727	0.2727
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0176	0.9978	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0059	0.2727	0.2733
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0041	0.1622	0.1625
Onchocerca volvulus		0.0059	0.2727	0.2727
Echinococcus granulosus	cathepsin L cysteine protease	0.0033	0.1106	0.1108
Trypanosoma cruzi	cysteine peptidase, putative	0.0033	0.1106	0.1108
Brugia malayi	Cathepsin L-like precursor	0.0041	0.1622	0.1622
Schistosoma mansoni	cathepsin F (C01 family)	0.0041	0.1622	0.1625
Onchocerca volvulus	Cathepsin L homolog	0.0059	0.2727	0.2727
Trypanosoma cruzi	cysteine proteinase, putative	0.0033	0.1106	0.1108
Brugia malayi	Cathepsin L-like precursor	0.0018	0.018	0.018
Loa Loa (eye worm)	cysteine protease	0.0059	0.2727	0.2727
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2727	0.8838
Entamoeba histolytica	cysteine protease, putative	0.0033	0.1106	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0176	0.9978	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0059	0.2727	0.2733
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.2727	0.2733
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0176	1	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0065	0.3086	1
Giardia lamblia	Cathepsin B precursor	0.0065	0.3086	1
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.1106	0.4054
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0065	0.3086	1
Onchocerca volvulus		0.0059	0.2727	0.2727
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.06	0.0601
Trypanosoma cruzi	cysteine proteinase, putative	0.0033	0.1106	0.1108
Brugia malayi	Cathepsin L-like precursor	0.0059	0.2727	0.2727
Brugia malayi	hypothetical protein	0.0016	0.0059	0.0059
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0065	0.3086	1
Brugia malayi	Cathepsin L-like precursor	0.0059	0.2727	0.2727
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.2727	1
Giardia lamblia	Cathepsin B precursor	0.0065	0.3086	1
Entamoeba histolytica	cysteine protease, putative	0.0033	0.1106	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0059	0.2727	1
Entamoeba histolytica	cysteine protease, putative	0.0033	0.1106	0.4054
Onchocerca volvulus		0.0059	0.2727	0.2727
Trypanosoma cruzi	cysteine peptidase, putative	0.0018	0.018	0.018
Entamoeba histolytica	cysteine protease, putative	0.0059	0.2727	1
Echinococcus granulosus	cathepsin l1	0.0059	0.2727	0.2733
Toxoplasma gondii	cathepsin CPL	0.0059	0.2727	0.8838
Echinococcus multilocularis	cathepsin L	0.0033	0.1106	0.1108
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2727	0.8557
Echinococcus granulosus	cathepsin b	0.0176	0.9978	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.018	0.018
Onchocerca volvulus		0.0059	0.2727	0.2727
Schistosoma mansoni	cathepsin s	0.0018	0.018	0.018
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0059	0.2727	0.2727
Leishmania major	cysteine peptidase A (CPA)	0.0059	0.2727	0.8557
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2727	0.8838
Entamoeba histolytica	cysteine protease, putative	0.0033	0.1106	0.4054
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.06	0.0601
Entamoeba histolytica	cysteine protease, putative	0.0033	0.1106	0.4054
Toxoplasma gondii	cathepsin B	0.0065	0.3086	1
Plasmodium vivax	vivapain-2	0.0059	0.2727	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.1106	0.2035
Onchocerca volvulus		0.0153	0.8594	0.8594
Echinococcus granulosus	cathepsin b	0.0176	0.9978	1
Leishmania major	cathepsin L-like protease	0.0059	0.2727	0.8557
Loa Loa (eye worm)	fibroinase	0.0059	0.2727	0.2727
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1622	0.1622
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2727	0.8838
Loa Loa (eye worm)	hypothetical protein	0.0018	0.018	0.018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2727	0.8838
Loa Loa (eye worm)	hypothetical protein	0.0153	0.8594	0.8594
Entamoeba histolytica	cysteine protease, putative	0.0033	0.1106	0.4054
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0033	0.1106	0.1108
Onchocerca volvulus		0.0059	0.2727	0.2727
Entamoeba histolytica	cysteine protease, putative	0.0033	0.1106	0.4054
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0041	0.1622	0.1622
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2727	0.8838
Leishmania major	cathepsin L-like protease	0.0059	0.2727	0.8557
Brugia malayi	cathepsin L-like precursor	0.0041	0.1622	0.1622
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2727	0.8557
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2727	0.8838
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2727	0.8838
Loa Loa (eye worm)	hypothetical protein	0.0025	0.06	0.06
Echinococcus granulosus	cathepsin L	0.0033	0.1106	0.1108
Echinococcus multilocularis	cathepsin b	0.0176	0.9978	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.2727	0.8838
Leishmania major	cathepsin L-like protease	0.0059	0.2727	0.8557
Trypanosoma cruzi	cysteine protease, putative	0.0033	0.1106	0.1108
Leishmania major	cathepsin L-like protease	0.0059	0.2727	0.8557
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.1106	0.1106
Echinococcus multilocularis	cathepsin b	0.0176	0.9978	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0059	0.2727	0.2727
Loa Loa (eye worm)	hypothetical protein	0.0018	0.018	0.018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2727	0.8838
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0059	0.2727	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.06	0.2199
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.06	0.1943
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.2727	0.2733
Leishmania major	cathepsin L-like protease	0.0059	0.2727	0.8557
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.2727	0.8838
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2727	0.8557
Brugia malayi	Papain family cysteine protease containing protein	0.0059	0.2727	0.2727
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0033	0.1106	0.1108
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.2727	0.8838
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2727	0.8838
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2727	0.8557
Plasmodium vivax	vivapain-1	0.0033	0.1106	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.2727	0.8838
Brugia malayi	Cathepsin L-like precursor	0.0059	0.2727	0.2727
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0176	0.9978	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0033	0.1106	0.1108
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1622	0.1622
Loa Loa (eye worm)	ctsf protein	0.0059	0.2727	0.2727
Plasmodium vivax	vivapain-3	0.0033	0.1106	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.2727	0.2733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2727	0.8838
Echinococcus multilocularis	cathepsin L cysteine protease	0.0059	0.2727	0.2733
Echinococcus multilocularis	cysteine protease	0.0059	0.2727	0.2733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1106	0.3583
Plasmodium vivax	unspecified product	0.0033	0.1106	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2727	0.8557
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2727	0.8557
Brugia malayi	Cathepsin L-like precursor	0.0059	0.2727	0.2727
Onchocerca volvulus	Cathepsin L homolog	0.0059	0.2727	0.2727
Entamoeba histolytica	cysteine protease, putative	0.0033	0.1106	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2727	0.8557
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0041	0.1622	0.5255
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.06	0.2199
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0018	0.018	0.018
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.2727	0.2733
Echinococcus multilocularis	cathepsin L cysteine protease	0.0059	0.2727	0.2733
Brugia malayi	hypothetical protein	0.0025	0.06	0.06
Plasmodium vivax	vivapain-2	0.0059	0.2727	1
Entamoeba histolytica	cysteine protease, putative	0.0033	0.1106	0.4054
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0065	0.3086	0.3093
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0041	0.1622	0.5255
Trypanosoma cruzi	cruzipain precursor, putative	0.0059	0.2727	0.2733
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0059	0.2727	0.8838
Brugia malayi	cathepsin F-like cysteine proteinase	0.0018	0.018	0.018
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.1106	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2727	0.8557
Entamoeba histolytica	cysteine protease, putative	0.0033	0.1106	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0041	0.1622	0.5946
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0059	0.2727	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0033	0.1106	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.2727	0.8838
Brugia malayi	Papain family cysteine protease containing protein	0.0033	0.1106	0.1106
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2727	0.8838
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0065	0.3086	0.3093
Plasmodium vivax	unspecified product	0.0018	0.018	0.066
Entamoeba histolytica	cysteine protease, putative	0.0033	0.1106	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0059	0.2727	0.2727
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0059	0.2727	1
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.1106	0.4054
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0059	0.2727	0.2733
Onchocerca volvulus		0.0059	0.2727	0.2727
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0033	0.1106	0.3583
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.2727	0.8838
Giardia lamblia	Cathepsin B precursor	0.0065	0.3086	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0059	0.2727	0.8838
Trypanosoma cruzi	cruzipain precursor, putative	0.0018	0.018	0.018
Onchocerca volvulus		0.0041	0.1622	0.1622
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0033	0.1106	0.2035
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0176	0.9978	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2727	0.8838
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2727	0.8557
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0059	0.2727	0.2733
Leishmania major	cathepsin L-like protease	0.0059	0.2727	0.8557
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.2727	0.8838
Brugia malayi	cathepsin B-like cysteine proteinase	0.0176	0.9978	0.9978
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0176	0.9978	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.06	0.2199
Leishmania major	cathepsin L-like protease	0.0059	0.2727	0.8557
Brugia malayi	hypothetical protein	0.0153	0.8594	0.8594
Loa Loa (eye worm)	hypothetical protein	0.0041	0.1622	0.1622
Entamoeba histolytica	cysteine protease, putative	0.0033	0.1106	0.4054
Echinococcus granulosus	cathepsin l1	0.0041	0.1622	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0176	1	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0033	0.1106	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.2727	0.8838
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0033	0.1106	0.1108
Loa Loa (eye worm)	hypothetical protein	0.0176	0.9978	0.9978
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2727	0.8557
Entamoeba histolytica	cysteine protease, putative	0.0033	0.1106	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0059	0.2727	0.8838
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.018	0.018
Loa Loa (eye worm)	cathepsin B	0.0065	0.3086	0.3086
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.2727	0.2733
Onchocerca volvulus	Cathepsin F homolog	0.0059	0.2727	0.2727
Echinococcus granulosus	cysteine protease	0.0033	0.1106	0.1108
Entamoeba histolytica	cysteine proteinase, putative	0.0033	0.1106	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0059	0.2727	0.2727
Brugia malayi	Cathepsin L-like precursor	0.0059	0.2727	0.2727
Entamoeba histolytica	cysteine proteinase 2	0.0033	0.1106	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0059	0.2727	0.8838
Schistosoma mansoni	cathepsin F (C01 family)	0.0059	0.2727	0.2733
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0059	0.2727	0.8557
Brugia malayi	Cathepsin L-like precursor	0.0041	0.1622	0.1622

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 25 nM	Inhibition of human recombinant cathepsin K	ChEMBL.	18571402
IC50 (binding)	= 53 nM	Inhibition of human recombinant cathepsin B	ChEMBL.	18571402
IC50 (binding)	= 625 nM	Inhibition of human recombinant cathepsin L	ChEMBL.	18571402

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL492617

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 995241