Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Hormone-sensitive lipase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.0061 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.6283 | 0.6283 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0142 | 0.4876 | 0.4876 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0 | 0.5 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0142 | 0.4876 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.6283 | 0.6283 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0038 | 0.0061 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0253 | 1 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0253 | 1 | 1 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0253 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0237 | 0.925 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0042 | 0.0222 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.0142 | 0.4876 | 0.4876 |
Echinococcus multilocularis | geminin | 0.0173 | 0.6283 | 0.6283 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0042 | 0.0222 | 1 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Echinococcus granulosus | geminin | 0.0173 | 0.6283 | 0.6283 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0253 | 1 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0142 | 0.4876 | 0.4876 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0042 | 0.0222 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0253 | 1 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0042 | 0.0222 | 0.0222 |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Onchocerca volvulus | 0.0037 | 0 | 0.5 | |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0042 | 0.0222 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0 | 0.5 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0038 | 0.0061 | 0.5 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0042 | 0.0222 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0138 | 0.4691 | 0.4691 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.98 uM | Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay | ChEMBL. | 18808096 |
Inhibition (binding) | = 45 % | Inhibition of HSL in Wistar rat isolated fat cells at 1 uM by spectrophotometric assay | ChEMBL. | 18808096 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.