Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Fatty acid desaturase 1 | Starlite/ChEMBL | References |
Homo sapiens | stearoyl-CoA desaturase (delta-9-desaturase) | Starlite/ChEMBL | References |
Rattus norvegicus | Fatty acid desaturase 2 | Starlite/ChEMBL | References |
Rattus norvegicus | Acyl-CoA desaturase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Fatty acid desaturase 2 | 444 aa | 422 aa | 29.6 % | |
Candida albicans | one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase | Acyl-CoA desaturase 1 | 358 aa | 317 aa | 27.1 % |
Dictyostelium discoideum | delta 5 fatty acid desaturase | Fatty acid desaturase 2 | 444 aa | 452 aa | 23.7 % |
Candida albicans | one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase | Acyl-CoA desaturase 1 | 358 aa | 317 aa | 27.1 % |
Dictyostelium discoideum | delta 5 fatty acid desaturase | Fatty acid desaturase 2 | 444 aa | 470 aa | 24.5 % |
Dictyostelium discoideum | delta 5 fatty acid desaturase | Fatty acid desaturase 2 | 444 aa | 464 aa | 26.1 % |
Onchocerca volvulus | Fatty acid desaturase 2 | 444 aa | 431 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | fatty acid desaturase, putative | 0.0247 | 0.7874 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.986 | 1 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0258 | 0.986 | 1 |
Leishmania major | delta-5 fatty acid desaturase | 0.0258 | 0.986 | 1 |
Loa Loa (eye worm) | FAT-3 protein | 0.0258 | 0.986 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.2126 | 0.2156 |
Schistosoma mansoni | fatty acid desaturase | 0.0259 | 1 | 0.5 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0205 | 0 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0205 | 0 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0247 | 0.7874 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.05 nM | Inhibition of Delta-9-desaturase in human HepG2 cells | ChEMBL. | 19249203 |
IC50 (binding) | = 0.05 nM | Inhibition of stearoyl-CoA delta9 desaturase in human HepG2 cells | ChEMBL. | 19577469 |
IC50 (binding) | = 0.6 nM | Inhibition of stearoyl-CoA delta9 desaturase in rat microsome | ChEMBL. | 19577469 |
IC50 (binding) | > 30 nM | Inhibition of rat microsomal Delta-5-desaturase | ChEMBL. | 19249203 |
IC50 (binding) | > 30 nM | Inhibition of rat microsomal Delta-6-desaturase | ChEMBL. | 19249203 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.