Detailed information for compound 998553

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 392.193 | Formula: C17H11Cl2N3O4
  • H donors: 2 H acceptors: 4 LogP: 4.84 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)Nc1[nH]c2c(Cl)cc(cc2c(=O)c1C(=O)C)[N+](=O)[O-]
  • InChi: 1S/C17H11Cl2N3O4/c1-8(23)14-16(24)12-6-11(22(25)26)7-13(19)15(12)21-17(14)20-10-4-2-9(18)3-5-10/h2-7H,1H3,(H2,20,21,24)
  • InChiKey: DVJGXMUWYFGXAS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens calpain 1, (mu/I) large subunit Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin H Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) calpain family protein 1 Get druggable targets OG5_127139 All targets in OG5_127139
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127139 All targets in OG5_127139
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis calpain A Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni family C2 unassigned peptidase (C02 family) Get druggable targets OG5_127139 All targets in OG5_127139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis calpain family protein 1, d Get druggable targets OG5_127139 All targets in OG5_127139
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K08585 calpain, invertebrate, putative Get druggable targets OG5_127139 All targets in OG5_127139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi calpain family protein 1 Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Calpain-1 catalytic subunit, putative Get druggable targets OG5_127139 All targets in OG5_127139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni family C2 unassigned peptidase (C02 family) Get druggable targets OG5_127139 All targets in OG5_127139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Calpain-A, putative Get druggable targets OG5_127139 All targets in OG5_127139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) calpain family protein 1 Get druggable targets OG5_127139 All targets in OG5_127139
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127139 All targets in OG5_127139
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni family C2 unassigned peptidase (C02 family) Get druggable targets OG5_127139 All targets in OG5_127139
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus calpain A Get druggable targets OG5_127139 All targets in OG5_127139
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus family C2 unassigned peptidase C02 family Get druggable targets OG5_127139 All targets in OG5_127139
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) Get druggable targets OG5_127139 All targets in OG5_127139
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_127139 All targets in OG5_127139
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127139 All targets in OG5_127139
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127139 All targets in OG5_127139
Brugia malayi calpain family protein 1 Get druggable targets OG5_127139 All targets in OG5_127139
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum cysteine proteinase falcipain 2b cathepsin H 335 aa 340 aa 33.2 %
Echinococcus granulosus calpain A calpain 1, (mu/I) large subunit 714 aa 753 aa 31.7 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0176 1 1
Entamoeba histolytica cysteine protease, putative 0.0033 0.0945 0.2667
Giardia lamblia Cathepsin B precursor 0.0065 0.2966 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.1772 0.486
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 1 1
Schistosoma mansoni calpain (C02 family) 0.0025 0.0443 0.0443
Onchocerca volvulus Cathepsin F homolog 0.0046 0.1772 1
Brugia malayi Cathepsin L-like precursor 0.0046 0.1772 0.1772
Onchocerca volvulus 0.0046 0.1772 1
Schistosoma mansoni cathepsin F (C01 family) 0.0046 0.1772 0.1772
Onchocerca volvulus 0.0046 0.1772 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0069 0.3226 0.3226
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0046 0.1772 0.486
Onchocerca volvulus Cathepsin L homolog 0.0046 0.1772 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0046 0.1772 0.1391
Entamoeba histolytica cysteine protease, putative 0.0033 0.0945 0.2667
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0443 0.0443
Loa Loa (eye worm) ctsf protein 0.0046 0.1772 0.1772
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.0945 0.0945
Onchocerca volvulus 0.0041 0.1466 0.7285
Schistosoma mansoni calpain-7 (C02 family) 0.0025 0.0443 0.0443
Entamoeba histolytica cysteine protease, putative 0.0033 0.0945 0.2667
Onchocerca volvulus Cathepsin L homolog 0.0046 0.1772 1
Entamoeba histolytica cysteine protease, putative 0.0033 0.0945 0.2667
Echinococcus granulosus cathepsin l cysteine peptidase 0.0046 0.1772 0.1391
Entamoeba histolytica cysteine proteinase, putative 0.0046 0.1772 1
Echinococcus granulosus cathepsin L cysteine protease 0.0033 0.0945 0.0525
Brugia malayi Cathepsin L-like precursor 0.0028 0.0644 0.0644
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.3038 0.3038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.1772 0.486
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.1772 0.1772
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 1 1
Brugia malayi Cathepsin L-like precursor 0.0046 0.1772 0.1772
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0945 0.0945
Brugia malayi Cathepsin L-like precursor 0.0046 0.1772 0.1772
Echinococcus multilocularis cysteine protease 0.0046 0.1772 0.1391
Echinococcus multilocularis cathepsin L cysteine protease 0.0046 0.1772 0.1391
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0025 0.0443 0.0443
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0025 0.0443 0.0443
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0046 0.1772 1
Entamoeba histolytica cysteine protease, putative 0.0033 0.0945 0.2667
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0028 0.0644 0.0644
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.1772 0.486
Toxoplasma gondii cathepsin B 0.0065 0.2966 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0945 0.1989
Brugia malayi calpain family protein 1 0.0066 0.3038 0.3038
Brugia malayi calpain family protein 1 0.0066 0.3038 0.3038
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0065 0.2966 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0033 0.0945 0.0945
Echinococcus multilocularis calpain A 0.0069 0.3226 0.2912
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.1772 0.486
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0025 0.0443 0.0443
Loa Loa (eye worm) hypothetical protein 0.0058 0.2565 0.2565
Schistosoma mansoni cathepsin F (C01 family) 0.0028 0.0644 0.0644
Schistosoma mansoni calpain-7 (C02 family) 0.0025 0.0443 0.0443
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.1772 0.486
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0046 0.1772 0.1772
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.1772 0.486
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0025 0.0443 0.0443
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.1772 0.486
Loa Loa (eye worm) calpain 0.0025 0.0443 0.0443
Schistosoma mansoni cathepsin F (C01 family) 0.0046 0.1772 0.1772
Brugia malayi Cathepsin L-like precursor 0.0046 0.1772 0.1772
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0069 0.3226 0.2912
Entamoeba histolytica cysteine protease, putative 0.0046 0.1772 1
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0069 0.3226 0.2912
Entamoeba histolytica cysteine protease, putative 0.0033 0.0945 0.2667
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.1772 0.5269
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0065 0.2966 1
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0945 0.0945
Echinococcus multilocularis cathepsin L 0.0033 0.0945 0.0525
Loa Loa (eye worm) hypothetical protein 0.0028 0.0644 0.0644
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.1772 0.486
Echinococcus multilocularis cathepsin b 0.0176 1 1
Entamoeba histolytica cysteine protease, putative 0.0033 0.0945 0.2667
Leishmania major cathepsin L-like protease 0.0046 0.1772 0.5269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.1772 0.486
Brugia malayi Cathepsin L-like cysteine proteinase 0.0028 0.0644 0.0644
Giardia lamblia Cathepsin B precursor 0.0065 0.2966 0.5
Echinococcus multilocularis cathepsin b 0.0176 1 1
Schistosoma mansoni Mername-AA248 (C02 family) 0.0025 0.0443 0.0443
Loa Loa (eye worm) hypothetical protein 0.0041 0.1466 0.1466
Plasmodium falciparum cysteine proteinase falcipain 3 0.0046 0.1772 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0065 0.2966 1
Brugia malayi cathepsin L-like precursor 0.0028 0.0644 0.0644
Echinococcus granulosus cathepsin L 0.0033 0.0945 0.0525
Echinococcus granulosus cathepsin L cysteine proteinase 0.0046 0.1772 0.1391
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0025 0.0443 0.0443
Entamoeba histolytica cysteine protease, putative 0.0033 0.0945 0.2667
Onchocerca volvulus 0.0046 0.1772 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.1772 0.486
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.1772 0.5269
Entamoeba histolytica cysteine proteinase 1, putative 0.0033 0.0945 0.2667
Loa Loa (eye worm) cysteine protease 0.0046 0.1772 0.1772
Leishmania major cysteine peptidase A (CPA) 0.0046 0.1772 0.5269
Trypanosoma cruzi cysteine protease, putative 0.0033 0.0945 0.0945
Echinococcus granulosus cathepsin b 0.0176 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.1772 0.1772
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0065 0.2966 0.2966
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0945 0.0945
Onchocerca volvulus 0.0046 0.1772 1
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0945 0.0945
Echinococcus granulosus cathepsin l1 0.0046 0.1772 0.1391
Giardia lamblia Cathepsin B precursor 0.0065 0.2966 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.1772 0.5269
Brugia malayi Cathepsin L-like precursor 0.0028 0.0644 0.0644
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.1772 0.486
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.1772 0.486
Loa Loa (eye worm) hypothetical protein 0.0028 0.0644 0.0644
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.1772 0.5269
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0046 0.1772 0.1772
Entamoeba histolytica cysteine protease, putative 0.0033 0.0945 0.2667
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.1772 0.5269
Echinococcus multilocularis cysteine protease 0.0046 0.1772 0.1391
Entamoeba histolytica cysteine protease, putative 0.0033 0.0945 0.2667
Loa Loa (eye worm) hypothetical protein 0.0048 0.1938 0.1938
Trypanosoma cruzi cruzipain precursor, putative 0.0046 0.1772 0.1772
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.1772 0.1772
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.1772 0.486
Entamoeba histolytica cysteine protease, putative 0.0033 0.0945 0.2667
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0025 0.0443 0.0443
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.1772 0.5269
Leishmania major cathepsin L-like protease 0.0046 0.1772 0.5269
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.1772 0.486
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.1772 0.5269
Loa Loa (eye worm) hypothetical protein 0.0066 0.3038 0.3038
Plasmodium vivax unspecified product 0.0033 0.0945 0.5331
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.1772 0.5269
Loa Loa (eye worm) fibroinase 0.0046 0.1772 0.1772
Entamoeba histolytica cysteine protease, putative 0.0033 0.0945 0.2667
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0945 0.0945
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.1772 0.486
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0046 0.1772 1
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0945 0.2667
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0945 0.1989
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.1772 0.486
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.1772 0.1772
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.1772 0.5269
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.1772 0.5269
Schistosoma mansoni calpain C (C02 family) 0.0025 0.0443 0.0443
Onchocerca volvulus 0.0046 0.1772 1
Leishmania major cathepsin L-like protease 0.0046 0.1772 0.5269
Plasmodium vivax calpain, putative 0.0025 0.0443 0.25
Leishmania major cathepsin L-like protease 0.0046 0.1772 0.5269
Loa Loa (eye worm) hypothetical protein 0.0028 0.0644 0.0644
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.1772 0.5269
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0945 0.2667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.1772 0.486
Leishmania major cathepsin L-like protease 0.0046 0.1772 0.5269
Onchocerca volvulus 0.0046 0.1772 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0945 0.1296
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0069 0.3226 0.3226
Plasmodium vivax vivapain-2 0.0046 0.1772 1
Brugia malayi calpain 7 0.0025 0.0443 0.0443
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0443 0.0443
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0176 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.1772 0.486
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.1772 0.486
Leishmania major cathepsin L-like protease 0.0046 0.1772 0.5269
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0046 0.1772 0.486
Plasmodium vivax vivapain-3 0.0033 0.0945 0.5331
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0065 0.2966 0.2966
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0443 0.0443
Entamoeba histolytica cysteine proteinase, putative 0.0046 0.1772 1
Loa Loa (eye worm) calpain family protein 1 0.0048 0.1938 0.1938
Loa Loa (eye worm) cathepsin B 0.0065 0.2966 0.2966
Onchocerca volvulus 0.0046 0.1772 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0046 0.1772 0.1391
Plasmodium vivax vivapain-1 0.0033 0.0945 0.5331
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0945 0.0945
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.1772 0.486
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0945 0.2667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0945 0.1296
Echinococcus multilocularis cathepsin L cysteine protease 0.0046 0.1772 0.1391
Brugia malayi Cathepsin L-like precursor 0.0046 0.1772 0.1772
Loa Loa (eye worm) calpain family protein 1 0.0066 0.3038 0.3038
Leishmania major cathepsin L-like protease 0.0046 0.1772 0.5269
Echinococcus multilocularis calpain family protein 1, d 0.0048 0.1938 0.1565
Leishmania major cathepsin L-like protease 0.0046 0.1772 0.5269
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0945 0.2667
Loa Loa (eye worm) hypothetical protein 0.0046 0.1772 0.1772
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.1772 0.1772
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.0945 0.0945
Echinococcus granulosus cathepsin b 0.0176 1 1
Entamoeba histolytica cysteine protease, putative 0.0033 0.0945 0.2667
Plasmodium vivax vivapain-2 0.0046 0.1772 1
Echinococcus granulosus calpain A 0.0069 0.3226 0.2912
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.1772 0.486
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0046 0.1772 0.486
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0025 0.0443 0.0443
Echinococcus granulosus cathepsin l1 0.0028 0.0644 0.021
Brugia malayi Cathepsin L-like precursor 0.0046 0.1772 0.1772
Loa Loa (eye worm) hypothetical protein 0.0176 1 1
Entamoeba histolytica cysteine proteinase 2 0.0033 0.0945 0.2667
Echinococcus granulosus cysteine protease 0.0033 0.0945 0.0525
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.1772 0.486

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.000437 uM Inhibition of human liver cathepsin L after 30 mins by fluorometric end-point assay ChEMBL. 19419206
IC50 (binding) = 0.0142 uM Inhibition of human liver cathepsin B after 30 mins by fluorometric end-point assay ChEMBL. 19419206
IC50 (binding) = 0.145 uM Inhibition of human liver cathepsin H after 30 mins by fluorometric end-point assay ChEMBL. 19419206
IC50 (binding) = 4.56 uM Inhibition of human erythrocytes mu-calpain after 30 mins by fluorometric assay using pep1 as substrate ChEMBL. 19419206
IC50 (binding) = 8.08 uM Inhibition of human erythrocytes mu-calpain by fluorometric assay using pep2 as substrate ChEMBL. 19419206
IC50 (binding) > 100 uM Inhibition of human liver cathepsin D after 30 mins by fluorometric end-point assay ChEMBL. 19419206

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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