Brugia targets ranked by Kumar et al.

Posted by Greg Crowther on 2008-07-10 01:41:55

WARNING: This list was made prior to the version 4 release of TDR Targets (Aug, 2010). Some queries included in this list may not work properly. Most likely reasons for this are changes in parameters, and/or data updates. If you experience any problem, please try re-running each search from the search page.

List description

Based on PLoS ONE 2: e1189, 2007. The authors first narrowed the Brugia genes down to those with essential orthologs in E. coli but lacking close homologs in humans. They then ranked these 589 genes with an algorithm based on data on homology, essentiality, stage-specific expression, druggability, and expressability. My list includes the top 10% of their rankings.

● Mining predicted essential genes of Brugia malayi for nematode drug targets. (2007). PLoS ONE 2: e1189 PubMed, Publisher.

Click on the links below to browse the contents of each query. You can also use the checkboxes to select queries you would like to import into your history.
Import ranked queries into your history to redo the scoring strategy
  • Brugia targets ranked by Kumar et al., re-revised (59 records), 3
    • Unmatched identifiers: () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; () ; ()
    • Query: Uploaded list