Detailed view for Tb08.27P2.140

Basic information

TDR Targets ID: 11875
Trypanosoma brucei, variant surface glycoprotein (VSG, atypical), putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.0409 | Length (AA): 531 | MW (Da): 57513 | Paralog Number: 66

Signal peptide: Y | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF10659   Trypanosome variant surface glycoprotein C-terminal domain
PF13206   Trypanosomal VSG domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_126790)

Species Accession Gene Product
Trypanosoma brucei Tb11.v5.0662   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.2.6430   variant surface glycoprotein, frameshift
Trypanosoma brucei Tb11.0610   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb11.v5.0872   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.11.19400   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb11.v5.0610   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb10.v4.0142   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.11.17320   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.11.18120   variant surface glycoprotein (VSG), frameshifted and degenerate
Trypanosoma brucei Tb927.11.17980   variant surface glycoprotein (VSG), degenerate
Trypanosoma brucei Tb927.9.17910   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb11.0710   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.11.17680   variant surface glycoprotein (VSG), point mutation
Trypanosoma brucei Tb927.11.19010   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb11.v5.0118   variant surface protein (VSG), putative
Trypanosoma brucei Tb10.v4.0056   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb11.v5.0592   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb10.v4.0089   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.5.5050   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb11.v5.0930   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.11.20700   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb927.11.17760   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb11.v5.0955   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb927.5.5660   Variant Surface Glycoprotein, putative
Trypanosoma brucei Tb927.11.20400   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.3.440   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb10.v4.0178   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb08.27P2.140   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb09.v4.0185   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.11.17960   variant surface glycoprotein (VSG), degenerate
Trypanosoma brucei Tb927.11.20490   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb11.v5.0518   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.1.5330   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb11.v5.0916   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb11.v5.0974   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb11.v5.0131   variant surface protein (VSG), putative
Trypanosoma brucei Tb927.11.17440   variant surface glycoprotein (VSG), degenerate
Trypanosoma brucei Tb927.5.5640   Variant Surface Glycoprotein, putative
Trypanosoma brucei Tb11.v5.0145   variant surface protein (VSG), putative
Trypanosoma brucei Tb927.11.18000   variant surface glycoprotein (VSG), frameshifted and point mutation
Trypanosoma brucei Tb11.v5.0950   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb927.9.16200   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb11.v5.0136   variant surface protein (VSG), putative
Trypanosoma brucei Tb927.10.16370   Variant Surface Glycoprotein, putative
Trypanosoma brucei Tb11.v5.0919   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb11.0590   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.11.17460   variant surface glycoprotein (VSG), frameshifted and interrupted
Trypanosoma brucei Tb927.8.460   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb09.v4.0077   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.3.340   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb11.v5.0973   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb10.v4.0145   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb927.9.580   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb11.v5.0956   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb10.v4.0100   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.9.17600   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.9.570   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb11.v5.0947   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.11.20660   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.11.19540   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb11.v5.0951   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb11.v5.0889   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb11.v5.0948   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb927.11.18190   variant surface glycoprotein (VSG), frameshifted
Trypanosoma brucei Tb927.11.19410   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb09.v4.0031   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb11.v5.1009   variant surface glycoprotein (VSG), putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Tb08.27P2.140 (Trypanosoma brucei), variant surface glycoprotein (VSG, atypical), putative
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