Detailed view for Tb927.9.9210

Basic information

TDR Targets ID: 14714
Trypanosoma brucei, 60S ribosomal protein L37, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 12.2255 | Length (AA): 84 | MW (Da): 10100 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01907   Ribosomal protein L37e

Gene Ontology

Mouse over links to read term descriptions.
GO:0022625   cytosolic large ribosomal subunit  
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

PDB tag
  • 3ZF7:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_126918)

Species Accession Gene Product
Arabidopsis thaliana AT1G52300   60S ribosomal protein L37-2
Arabidopsis thaliana AT1G15250   60S ribosomal protein L37-1
Arabidopsis thaliana AT3G16080   60S ribosomal protein L37-3
Babesia bovis BBOV_III004310   60S ribosomal protein L37e, putative
Brugia malayi Bm1_15745   60S ribosomal protein L37-A
Caenorhabditis elegans CELE_C54C6.1   Protein RPL-37
Caenorhabditis elegans CELE_W01D2.1   Protein W01D2.1
Cryptosporidium hominis Chro.20237   ribosomal protein L37e
Cryptosporidium parvum cgd2_2200   60S ribosomal protein L37
Dictyostelium discoideum DDB_G0285971   ribosomal protein L37
Drosophila melanogaster Dmel_CG9091   Ribosomal protein L37a
Drosophila melanogaster Dmel_CG9873   Ribosomal protein L37b
Echinococcus granulosus EgrG_000183700   ribosomal protein L37a
Entamoeba histolytica EHI_156690   60S ribosomal protein L37
Entamoeba histolytica EHI_048990   60S ribosomal protein L37
Entamoeba histolytica EHI_025600   60S ribosomal protein L37, putative
Entamoeba histolytica EHI_015320   60S ribosomal protein L37
Entamoeba histolytica EHI_158270   60S ribosomal protein L37
Echinococcus multilocularis EmuJ_000183700   ribosomal protein L37a
Giardia lamblia GL50803_14171   Ribosomal protein L37
Homo sapiens 6167   ribosomal protein L37
Leishmania braziliensis LbrM.34.5040   60S ribosomal protein L37
Leishmania donovani LdBPK_332070.1   60S ribosomal protein L37
Leishmania infantum LinJ.35.5420   60S ribosomal protein L37
Leishmania infantum LinJ.33.2070   60S ribosomal protein L37
Leishmania major LmjF.33.1955   60S ribosomal protein L37
Leishmania major LmjF.35.5100   60S ribosomal protein L37
Leishmania mexicana LmxM.32.1955   60S ribosomal protein L37
Leishmania mexicana LmxM.34.5100   60S ribosomal protein L37
Loa Loa (eye worm) LOAG_02185   60S ribosomal protein L37-A
Mus musculus ENSMUSG00000041841   ribosomal protein L37
Mus musculus 100502825   predicted gene 13826
Neospora caninum NCLIV_015990   hypothetical protein
Oryza sativa 4344579   Os08g0128500
Oryza sativa 4328048   Os02g0111700
Oryza sativa 9267955   Os02g0815001
Onchocerca volvulus OVOC11013   60S ribosomal protein L37 homolog
Plasmodium berghei PBANKA_0804000   60S ribosomal protein L37, putative
Plasmodium falciparum PF3D7_0706400   60S ribosomal protein L37
Plasmodium knowlesi PKNH_0104900   60S ribosomal protein L37, putative
Plasmodium vivax PVX_087860   60S ribosomal protein L37, putative
Plasmodium yoelii PY02795   Ribosomal protein L37e, putative
Saccharomyces cerevisiae YDR500C   ribosomal 60S subunit protein L37B
Saccharomyces cerevisiae YLR185W   ribosomal 60S subunit protein L37A
Schistosoma japonicum Sjp_0014990   ko:K02922 large subunit ribosomal protein L37e, putative
Schistosoma mansoni Smp_035800   60S ribosomal protein L37
Schmidtea mediterranea mk4.005517.01   60S ribosomal protein L37
Schmidtea mediterranea mk4.015298.01   60S ribosomal protein L37
Trypanosoma brucei gambiense Tbg972.11.3320   60S ribosomal protein L37, putative
Trypanosoma brucei gambiense Tbg972.9.5150   60S ribosomal protein L37, putative
Trypanosoma brucei Tb927.11.3000   60S ribosomal protein L37, putative
Trypanosoma brucei Tb927.9.9210   60S ribosomal protein L37, putative
Trypanosoma cruzi TcCLB.507773.34   60S ribosomal protein L37, putative
Trypanosoma cruzi TcCLB.510431.274   60S ribosomal protein L37, putative
Trypanosoma cruzi TcCLB.506885.14   ribosomal protein L37, putative
Toxoplasma gondii TGME49_239330   ribosomal protein RPL37
Theileria parva TP02_0235   60S ribosomal protein L37, putative
Trichomonas vaginalis TVAG_454260   60S ribosomal protein L37, putative
Trichomonas vaginalis TVAG_432450   60S ribosomal protein L37, putative
Trichomonas vaginalis TVAG_339320   60S ribosomal protein L37, putative
Trichomonas vaginalis TVAG_067100   60S ribosomal protein L37, putative
Trichomonas vaginalis TVAG_005760   60S ribosomal protein L37, putative

Essentiality

Tb927.9.9210 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.0865 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.211.0865 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.211.0865 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.211.0865 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.02.0500 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.02.0500 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.02.0500 this record Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.02.0500 this record Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C54C6.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_C54C6.1 Caenorhabditis elegans larval arrest wormbase
CELE_C54C6.1 Caenorhabditis elegans slow growth wormbase
CELE_C54C6.1 Caenorhabditis elegans sterile wormbase
CELE_W01D2.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_W01D2.1 Caenorhabditis elegans larval arrest wormbase
CELE_W01D2.1 Caenorhabditis elegans slow growth wormbase
PBANKA_0804000 Plasmodium berghei Essential plasmo
TGME49_239330 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) decreased (PATO:0000468) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 3 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in procyclic forms . References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Tb927.9.9210 (Trypanosoma brucei), 60S ribosomal protein L37, putative
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