Detailed view for PF3D7_1351100

Basic information

TDR Targets ID: 172
Plasmodium falciparum, conserved protein, unknown function
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 4.3342 | Length (AA): 156 | MW (Da): 18691 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05907   Eukaryotic protein of unknown function (DUF866)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 156 1zso (A) 1 156 99.99 0 1 2.17 -1.75
1 156 1zso (A) 1 156 99.99 0 1 2.2684 -1.76

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 1ZSO:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 48 hs, sporozoite, early ring, early trophozoite, late ring, late trophozoite, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 40 hs, merozoite, early schizont, late schizont, Oocyst. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Male Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile gametocyte, Female Gametocyte. PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Sporozoite. Zanghi G
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.

Orthologs

Ortholog group members (OG5_128549)

Species Accession Gene Product
Arabidopsis thaliana AT4G32930   hypothetical protein
Babesia bovis BBOV_I004060   conserved hypothetical protein
Candida albicans CaO19.8972   conserved hypothetical protein similar to N. crassa NCU08505.1, S. pombe SPBC2D10.03c and S. cerevisiae YCR090C
Candida albicans CaO19.1394   conserved hypothetical protein similar to N. crassa NCU08505.1, S. pombe SPBC2D10.03c and S. cerevisiae YCR090C
Caenorhabditis elegans CELE_F46B6.12   Protein F46B6.12
Cryptosporidium hominis Chro.30197   hypothetical protein
Cryptosporidium parvum cgd3_1630   hypothetical protein
Dictyostelium discoideum DDB_G0270194   DUF866 family protein
Drosophila melanogaster Dmel_CG4646   CG4646 gene product from transcript CG4646-RB
Echinococcus granulosus EgrG_000153900   protein of unknown function DUF866 eukaryotic
Echinococcus multilocularis EmuJ_000153900   protein of unknown function DUF866, eukaryotic
Giardia lamblia GL50803_5568   Hypothetical protein
Homo sapiens ENSG00000162384   chromosome 1 open reading frame 123
Leishmania braziliensis LbrM.12.0440   hypothetical protein, conserved
Leishmania donovani LdBPK_120370.1   Eukaryotic protein of unknown function (DUF866), putative
Leishmania infantum LinJ.12.0370   hypothetical protein, conserved
Leishmania major LmjF.12.0410   hypothetical protein, conserved
Leishmania mexicana LmxM.12.0410   hypothetical protein, conserved
Mus musculus ENSMUSG00000028608   RIKEN cDNA 0610037L13 gene
Neospora caninum NCLIV_041300   C1orf123, related
Oryza sativa 4327927   Os01g0565600
Plasmodium berghei PBANKA_1363900   conserved protein, unknown function
Plasmodium falciparum PF3D7_1351100   conserved protein, unknown function
Plasmodium knowlesi PKNH_1249800   conserved protein, unknown function
Plasmodium vivax PVX_083450   conserved protein, unknown function
Plasmodium yoelii PY06217   hypothetical protein
Saccharomyces cerevisiae YCR090C   hypothetical protein
Schistosoma japonicum Sjp_0203240   IPR008584,Protein of unknown function DUF866, eukaryotic,domain-containing
Schistosoma mansoni Smp_050880   hypothetical protein
Trypanosoma brucei gambiense Tbg972.1.2140   hypothetical protein, conserved
Trypanosoma brucei Tb927.1.3390   Eukaryotic protein of unknown function (DUF866), putative
Trypanosoma congolense TcIL3000_0_54820   Eukaryotic protein of unknown function (DUF866), putative
Trypanosoma congolense TcIL3000_0_60080   Eukaryotic protein of unknown function (DUF866), putative
Trypanosoma cruzi TcCLB.506529.669   Eukaryotic protein of unknown function (DUF866), putative
Trypanosoma cruzi TcCLB.510889.340   Eukaryotic protein of unknown function (DUF866), putative
Toxoplasma gondii TGME49_288910   DUF866 domain-containing protein
Theileria parva TP02_0714   hypothetical protein, conserved
Trichomonas vaginalis TVAG_414020   conserved hypothetical protein

Essentiality

PF3D7_1351100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.1.3390 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.1.3390 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.1.3390 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.1.3390 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_288910 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

  • Pfal004331AAA;
  • Type Source Notes
    soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Pfal004331; Recombinant protein: full-length; Source: P falciparum; hypothetical protein, conserved ;

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_1351100 (Plasmodium falciparum), conserved protein, unknown function
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