pI: 5.1071 |
Length (AA): 288 |
MW (Da): 32095 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
18 | 282 | 5jgk (A) | 7 | 261 | 17.00 | 0 | 1 | 1.05284 | -0.01 |
24 | 256 | 4obx (A) | 73 | 306 | 45.00 | 0 | 1 | 1.37283 | -1.11 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127211)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G57300 | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase |
Babesia bovis | BBOV_III009020 | ubiquinone/menaquinone biosynthesis methyltransferases family protein |
Brugia malayi | Bm1_26350 | Ubiquinone biosynthesis methyltransferase ZK652.9, putative |
Candida albicans | CaO19.3577 | putative mitochondrial C-methyltransferase |
Candida albicans | CaO19.11061 | putative mitochondrial C-methyltransferase |
Caenorhabditis elegans | CELE_ZK652.9 | Protein COQ-5 |
Cryptosporidium hominis | Chro.10320 | hypothetical protein |
Cryptosporidium parvum | cgd1_2860 | hypothetical protein |
Chlamydia trachomatis | CT_428 | demethylmenaquinone methyltransferase |
Dictyostelium discoideum | DDB_G0280237 | ubiE/COQ5 methyltransferase family protein |
Drosophila melanogaster | Dmel_CG2453 | CG2453 gene product from transcript CG2453-RC |
Escherichia coli | b3833 | bifunctional 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase/S-adenosylmethionine:2-DMK methyltransferase |
Echinococcus granulosus | EgrG_000905300 | 2 methoxy 6 polyprenyl 14 benzoquinol |
Echinococcus multilocularis | EmuJ_000905300 | 2 methoxy 6 polyprenyl 1,4 benzoquinol |
Homo sapiens | ENSG00000110871 | coenzyme Q5 homolog, methyltransferase (S. cerevisiae) |
Leishmania braziliensis | LbrM.35.5610 | ubiquinone biosynthesis methyltransferase, putative |
Leishmania donovani | LdBPK_365590.1 | ubiquinone biosynthesis methyltransferase, putative |
Leishmania infantum | LinJ.36.5590 | ubiquinone biosynthesis methyltransferase, putative |
Leishmania major | LmjF.36.5360 | ubiquinone biosynthesis methyltransferase, putative |
Leishmania mexicana | LmxM.36.5360 | ubiquinone biosynthesis methyltransferase, putative |
Loa Loa (eye worm) | LOAG_00003 | ubiquinone biosynthesis methyltransferase |
Mycobacterium leprae | ML2273 | PROBABLE UBIQUINONE/MENAQUINONE BIOSYNTHESIS METHYLTRANSFERASE MENH (2-heptaprenyl-1,4-naphthoquinone methyltransferase) |
Mus musculus | ENSMUSG00000041733 | coenzyme Q5 homolog, methyltransferase (yeast) |
Mycobacterium tuberculosis | Rv0558 | Probable ubiquinone/menaquinone biosynthesis methyltransferase MenH (2-heptaprenyl-1,4-naphthoquinone methyltransferase) |
Mycobacterium ulcerans | MUL_0660 | ubiquinone/menaquinone biosynthesis methyltransferase |
Mycobacterium ulcerans | MUL_0820 | methyltransferase |
Neospora caninum | NCLIV_002130 | ubiquinone/menaquinone biosynthesis methyltransferae, putative |
Oryza sativa | 4324310 | Os01g0976600 |
Plasmodium berghei | PBANKA_0302700 | methyltransferase, putative |
Plasmodium falciparum | PF3D7_0204900 | ubiE/COQ5 methyltransferase, putative |
Plasmodium knowlesi | PKNH_0416000 | DEAD/DEAH box helicase, putative |
Plasmodium vivax | PVX_003675 | ubiquinone biosynthesis methyltransferase, putative |
Plasmodium yoelii | PY00901 | methlytransferase, UbiE/COQ5 family |
Saccharomyces cerevisiae | YML110C | 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase |
Schistosoma japonicum | Sjp_0105150 | ko:K00599 methyltransferase [EC:2.1.1.-], putative |
Schistosoma mansoni | Smp_021910 | ubiquinone/menaquinone biosynthesis methyltransferase |
Schmidtea mediterranea | mk4.003844.02 | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial |
Schmidtea mediterranea | mk4.003844.01 | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial |
Trypanosoma brucei gambiense | Tbg972.11.11780 | ubiquinone biosynthesis methyltransferase, putative |
Trypanosoma brucei | Tb927.11.10510 | ubiquinone biosynthesis methyltransferase, putative |
Trypanosoma congolense | TcIL3000.11.11100 | ubiquinone biosynthesis methyltransferase, putative |
Trypanosoma congolense | TcIL3000_0_52950 | ubiquinone biosynthesis methyltransferase, putative |
Trypanosoma cruzi | TcCLB.503823.160 | ubiquinone biosynthesis methyltransferase, putative |
Trypanosoma cruzi | TcCLB.510285.60 | ubiquinone biosynthesis methyltransferase, putative |
Toxoplasma gondii | TGME49_295690 | ubiquinone/menaquinone biosynthesis methyltransferase subfamily protein |
Theileria parva | TP04_0806 | ubiquinone/menaquinone biosynthesis methyltransferase, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0202 | ubiquinone/menaquinone biosynthesis methylase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu566 | Mycobacterium tuberculosis | essential | nmpdr |
Tb11.01.2280 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.2280 this record | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.2280 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.2280 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3833 | Escherichia coli | essential | goodall |
PBANKA_0302700 | Plasmodium berghei | Essential | plasmo |
TGME49_295690 | Toxoplasma gondii | Probably essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
33 literature references were collected for this gene.