pI: 11.131 |
Length (AA): 213 |
MW (Da): 24736 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_126951)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G26910 | 60S ribosomal protein L10-2 |
Arabidopsis thaliana | AT1G66580 | 60S ribosomal protein L10-3 |
Babesia bovis | BBOV_III010500 | ribosomal protein L10, putative |
Brugia malayi | Bm1_34250 | 60S ribosomal protein L10 |
Candida albicans | CaO19.2935 | likely cytosolic ribosomal protein similar to S. cerevisiae RPL10 (YLR075W) large subunit protein L10 |
Candida albicans | CaO19.10452 | likely cytosolic ribosomal protein similar to S. cerevisiae RPL10 (YLR075W) large subunit protein L10 |
Caenorhabditis elegans | CELE_F10B5.1 | Protein RPL-10 |
Cryptosporidium hominis | Chro.60480 | ribosomal protein L10 |
Cryptosporidium parvum | cgd6_4190 | 60S ribosomal protein L10, alpha/beta hammerhead |
Dictyostelium discoideum | DDB_G0288273 | S60 ribosomal protein L10 |
Drosophila melanogaster | Dmel_CG17521 | Ribosomal protein L10 |
Echinococcus granulosus | EgrG_000094300 | 60S ribosomal protein L10 |
Entamoeba histolytica | EHI_044810 | ribosomal protein L10, putative |
Entamoeba histolytica | EHI_098780 | ribosomal protein L10, putative |
Entamoeba histolytica | EHI_185010 | ribosomal protein L10, putative |
Echinococcus multilocularis | EmuJ_000094300 | 60S ribosomal protein L10 |
Giardia lamblia | GL50803_10428 | Ribosomal protein L10 |
Homo sapiens | ENSG00000165496 | ribosomal protein L10-like |
Homo sapiens | ENSG00000147403 | ribosomal protein L10 |
Leishmania braziliensis | LbrM.04.0950 | 60S ribosomal protein L10, putative |
Leishmania braziliensis | LbrM.04.0740 | 60S ribosomal protein L10, putative |
Leishmania donovani | LdBPK_040750.1 | 60S ribosomal protein L10, putative |
Leishmania infantum | LinJ.04.0750 | 60S ribosomal protein L10, putative |
Leishmania infantum | LinJ.04.0950 | 60S ribosomal protein L10, putative |
Leishmania major | LmjF.04.0950 | 60S ribosomal protein L10, putative |
Leishmania major | LmjF.04.0750 | 60S ribosomal protein L10, putative |
Leishmania mexicana | LmxM.04.0950 | |
Loa Loa (eye worm) | LOAG_04367 | 60S ribosomal protein L10 |
Mus musculus | ENSMUSG00000008682 | ribosomal protein L10 |
Mus musculus | ENSMUSG00000060499 | ribosomal protein L10-like |
Mus musculus | 434434 | predicted gene 5621 |
Neospora caninum | NCLIV_041180 | 60S ribosomal protein L10, related |
Oryza sativa | 4337928 | Os05g0169100 |
Oryza sativa | 4350098 | Os11g0220800 |
Oryza sativa | 4332737 | Os03g0332500 |
Plasmodium berghei | PBANKA_1028400 | 60S ribosomal protein L10, putative |
Plasmodium falciparum | PF3D7_1414300 | 60S ribosomal protein L10, putative |
Plasmodium knowlesi | PKNH_1343800 | 60S ribosomal protein L10, putative |
Plasmodium vivax | PVX_085735 | 60S ribosomal protein L10, putative |
Plasmodium yoelii | PY07431 | Ribosomal L10, putative |
Saccharomyces cerevisiae | YLR075W | ribosomal 60S subunit protein L10 |
Schistosoma japonicum | Sjp_0046280 | ko:K02866 large subunit ribosomal protein L10e, putative |
Schistosoma japonicum | Sjp_0037300 | 60S ribosomal protein L10, putative |
Schistosoma mansoni | Smp_013200.2 | 60S ribosomal protein L10 |
Schistosoma mansoni | Smp_013200.1 | 60S ribosomal protein L10 |
Schmidtea mediterranea | mk4.020561.00 | 60S ribosomal protein L10 |
Schmidtea mediterranea | mk4.000466.07 | 60S ribosomal protein L10 |
Schmidtea mediterranea | mk4.000500.07 | 60S ribosomal protein L10 |
Schmidtea mediterranea | mk4.032294.01 | 60S ribosomal protein L10 |
Schmidtea mediterranea | mk4.003708.05 | 60S ribosomal protein L10 |
Schmidtea mediterranea | mk4.001001.00 | 60S ribosomal protein L10 |
Trypanosoma brucei gambiense | Tbg972.9.4600 | 60S ribosomal protein L10, putative,QM-like protein |
Trypanosoma brucei gambiense | Tbg972.9.4410 | 60S ribosomal protein L10, putative,QM-like protein |
Trypanosoma brucei | Tb927.9.8420 | QM-like protein |
Trypanosoma brucei | Tb927.9.8070 | QM-like protein |
Trypanosoma congolense | TcIL3000_9_2800 | 60S ribosomal protein L10, putative |
Trypanosoma congolense | TcIL3000_9_2910 | 60S ribosomal protein L10, putative |
Trypanosoma cruzi | TcCLB.510241.50 | 60S ribosomal protein L10, putative |
Trypanosoma cruzi | TcCLB.510243.40 | 60S ribosomal protein L10, putative |
Trypanosoma cruzi | TcCLB.510579.80 | 60S ribosomal protein L10, putative |
Trypanosoma cruzi | TcCLB.510575.190 | 60S ribosomal protein L10, putative |
Toxoplasma gondii | TGME49_288720 | ribosomal protein RPL10 |
Theileria parva | TP02_0093 | 60S ribosomal protein L10, putative |
Trichomonas vaginalis | TVAG_232820 | 60S ribosomal protein L10, putative |
Trichomonas vaginalis | TVAG_437020 | 50S ribosomal protein L10e, putative |
Trichomonas vaginalis | TVAG_291010 | 60S ribosomal protein L10, putative |
Trichomonas vaginalis | TVAG_074610 | 60S ribosomal protein L10, putative |
Trichomonas vaginalis | TVAG_407240 | 60S ribosomal protein L10, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.211.0110 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb09.211.0110 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb09.211.0110 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb09.211.0110 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb09.211.0340 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb09.211.0340 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb09.211.0340 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb09.211.0340 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F10B5.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F10B5.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F10B5.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F10B5.1 | Caenorhabditis elegans | sterile | wormbase |
YLR075W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_288720 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.