Detailed view for LmjF.36.3180

Basic information

TDR Targets ID: 21915
Leishmania major, receptor-type adenylate cyclase a-like protein
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.5059 | Length (AA): 1401 | MW (Da): 150455 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00211   Adenylate and Guanylate cyclase catalytic domain
PF09149   Domain of unknown function (DUF1935)

Gene Ontology

Mouse over links to read term descriptions.
GO:0035556   GO:intracellular signal transduction  

GO:0016849   phosphorus-oxygen lyase activity  
GO:0009190   cyclic nucleotide biosynthetic process  
GO:0007242   intracellular signaling cascade  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
22 422 1dp4 (A) 1 415 8.00 0 0.96 0.16 -0.51
37 414 1pea () 8 364 9.00 0 0.81 0.23 -1.07
853 1066 1fx2 (A) 888 1111 56.00 0 1 0.88 -1.4
1288 1401 1r75 (A) 12 128 30.00 0 0.95 0.46 -0.86
44 380 4n0q (A) 24 348 13.00 0 0.99 0.335742 -0.05
113 343 3lkb (A) 89 302 14.00 0 0.5 0.268082 -0.16
115 343 3sg0 (A) 105 324 16.00 0 0.98 0.346655 0.1
452 642 5hgr (A) 12 221 31.00 0.28 0.26 0.194831 0.96
577 713 4hk5 (A) 245 373 29.00 0.55 0.14 0.177287 0.53
853 1073 1fx4 (A) 876 1106 53.00 0.000000000006 1 0.838944 -1.1
1277 1400 2fe0 (A) 1 121 35.00 0 0.85 0.529708 -0.45
1288 1401 1r75 (A) 12 128 31.00 0 0.86 0.44257 -0.74

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_171511)

Species Accession Gene Product
Leishmania braziliensis LbrM.35.3400   receptor-type adenylate cyclase a-like protein
Leishmania donovani LdBPK_363330.1   receptor-type adenylate cyclase a-like protein
Leishmania infantum LinJ.36.3330   receptor-type adenylate cyclase a-like protein
Leishmania major LmjF.36.3180   receptor-type adenylate cyclase a-like protein
Leishmania mexicana LmxM.36.3180   receptor-type adenylate cyclase a-like protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Leishmania major small myristoylated protein-2 136 aa 36.3% 113 aa Compounds References
Leishmania major small myristoylated protein-3, putative 115 aa 37.6% 109 aa Compounds References
Leishmania major small myristoylated protein-1 131 aa 37.2% 113 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0285 0.2766 0.2989
0.0249 0.2651 0.2651
0.0292 0.302 0.302
0.0264 0.3022 0.3022
0.0282 0.2706 0.3096
0.0304 0.3008 0.3068
0.031 0.3022 0.3022
0.032 0.3023 0.3022
0.0269 0.3022 0.3022
0.0299 0.3007 0.2962
0.0287 0.2746 0.2962
0.0301 0.2936 0.2909
0.0259 0.3022 0.3022
0.0311 0.2891 0.2874
0.0647 0.3006 0.295
0.0304 0.2959 0.3068
0.0299 0.3038 0.3038
0.0268 0.3022 0.3022
0.0292 0.302 0.302
0.0276 0.2611 0.2813
0.0304 0.3065 0.3106
0.0468 0.299 0.2979
0.0654 0.3006 0.295
0.0651 0.299 0.2979
0.0276 0.2792 0.3114
0.0323 0.2952 0.295
0.0353 0.2581 0.3099
0.0619 0.299 0.2979
0.0267 0.2923 0.2862
0.0289 0.2951 0.295
0.0279 0.2915 0.2909
0.0276 0.2792 0.3114
0.0271 0.3027 0.3022
0.0293 0.2965 0.2909
0.0144 0.2852 0.2745
0.0269 0.3022 0.3022
0.0278 0.3022 0.3022
0.0587219 0.280237 0.27328
0.0619 0.299 0.2979
0.0587 0.299 0.2979
0.0304727 0.252447 0.250702
0.0266 0.2706 0.307
0.0269 0.3022 0.3022
0.0262 0.3027 0.3022
0.0323 0.3111 0.3107
0.0293 0.3022 0.3022
0.0651 0.299 0.2979
0.0273 0.2915 0.2909
0.0284 0.2873 0.2827
0.0615 0.299 0.2979
0.0317 0.3007 0.2962
0.0317 0.3007 0.2962
0.0249 0.2651 0.2651
0.0647 0.3006 0.295
0.0305 0.3022 0.3022
0.0619 0.299 0.2979
0.03 0.3112 0.3097
0.0275 0.2934 0.2909
0.0276 0.2792 0.3114
0.0294 0.3051 0.3068
0.0323 0.2888 0.2888
0.0263 0.3103 0.3096
0.0278 0.281 0.2745
0.0587 0.299 0.2979
0.0323 0.3066 0.295
0.0323 0.3111 0.3107
0.0269 0.3112 0.3096
0.0555 0.299 0.2979
0.0294 0.3112 0.3096
0.0311 0.2891 0.2874
0.0276 0.3007 0.2962
0.0285 0.2635 0.2954
0.021 0.316 0.3154
0.0318 0.3117 0.3114
0.0265 0.2968 0.2909
0.032 0.307 0.3068
0.0208 0.301 0.301
0.0285 0.2943 0.295
0.0647 0.2979 0.295
0.0500157 0.280356 0.27328
0.0647 0.299 0.2979
0.0314 0.307 0.3068
0.0263 0.2832 0.2697
0.0500157 0.280356 0.27328
0.0312 0.307 0.3068
0.031 0.2997 0.2914
0.0208 0.301 0.301
0.0284 0.2935 0.2909
0.0267 0.2938 0.2909
0.0261 0.2734 0.295
0.0282 0.3112 0.3096
0.0289 0.2888 0.2847
0.0314 0.307 0.3068
0.0263 0.2909 0.2909
0.0317 0.3022 0.3022
0.0264 0.2862 0.2862
0.0268 0.2883 0.2816
0.0265 0.3103 0.3096
0.032 0.307 0.3068
0.0555 0.299 0.2979
0.0144 0.2745 0.2745
0.0249 0.2651 0.2651
0.0263 0.307 0.3068
0.0278 0.3007 0.2962
0.0262 0.3022 0.3022
0.0279 0.2938 0.2909
0.0318 0.307 0.3068
0.0292 0.2941 0.2958
0.0293 0.3007 0.2962
0.0262 0.3027 0.3022
0.0304 0.3008 0.3068
0.0293 0.2979 0.295
0.0647 0.299 0.2979
0.0317 0.3007 0.2962
0.0269 0.2915 0.2909
0.0292 0.302 0.302
0.0281 0.2806 0.2821
0.0267 0.2923 0.2862
0.0315 0.3112 0.3097
0.0318 0.3117 0.3114
0.0261 0.2734 0.295
0.0287 0.2746 0.2962
0.0275 0.3007 0.2962
0.0651 0.299 0.2979
0.0205 0.2872 0.2745
0.0269 0.3022 0.3022
0.0615 0.299 0.2979
0.0293 0.3007 0.2962
0.0275 0.3112 0.3096
0.0262 0.2859 0.2745
0.026 0.3098 0.3068
0.0275 0.3007 0.2962
0.0274 0.269 0.295
0.0278 0.3096 0.3096
0.0249 0.2651 0.2651
0.0278 0.3022 0.3022
0.0274 0.269 0.295
0.0289 0.2668 0.2956
0.0583 0.299 0.2979
0.0323 0.2852 0.2784
0.0265 0.3103 0.3096
0.0259 0.2877 0.3114
0.0292 0.2872 0.2849
0.0261 0.2734 0.295
0.0615 0.299 0.2979
0.026 0.3022 0.3022
0.0262 0.2951 0.295
0.0291 0.2951 0.295
0.0279 0.3103 0.3096
0.0208 0.2991 0.295
0.0146 0.2979 0.295
0.0263 0.307 0.3068
0.0312 0.307 0.3068
0.0273 0.3112 0.3096
0.0288 0.3022 0.3022
0.0583 0.299 0.2979
0.0323 0.3111 0.3107
0.0314 0.3007 0.2962
0.0288 0.3022 0.3022
0.0615 0.299 0.2979
0.0283 0.3007 0.2962
0.0203 0.2672 0.2651
0.0587 0.299 0.2979
0.0318 0.3117 0.3114
0.0271 0.3007 0.2962

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier LmjF.36.3180 (Leishmania major), receptor-type adenylate cyclase a-like protein
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