Detailed view for Bm1_05720

Basic information

TDR Targets ID: 236804
Brugia malayi, Protein kinase domain containing protein
Source Database / ID:  GenBank

pI: 9.4375 | Length (AA): 404 | MW (Da): 46268 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

Cell cycle (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
11 403 2j0i (A) 312 571 28.00 0 1 0.654572 1.21
18 176 1x8b (A) 292 477 27.00 0 1 0.719364 -0.63
26 403 4f9a (A) 58 568 40.00 0 1 1.03944 0.69
109 165 3vut (A) 202 250 47.00 0.11 0.38 0.222089 1.11
127 184 2izr (A) 146 209 40.00 0.000045 0.98 0.503564 0.22

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129189)

Species Accession Gene Product
Arabidopsis thaliana AT4G16970   protein kinase superfamily protein
Brugia malayi Bm1_05720   Protein kinase domain containing protein
Candida albicans CaO19.11045   protein serine/threonine kinase
Candida albicans CaO19.3561   protein serine/threonine kinase
Caenorhabditis elegans CELE_C34G6.5   Protein CDC-7
Dictyostelium discoideum DDB_G0292152   CDC7 family protein kinase
Dictyostelium discoideum DDB_G0270756   GATA zinc finger domain-containing protein 7
Drosophila melanogaster Dmel_CG5790   CG5790 gene product from transcript CG5790-RB
Drosophila melanogaster Dmel_CG32742   lethal (1) G0148
Echinococcus granulosus EgrG_000953500   CDC7 cell division cycle 7
Echinococcus multilocularis EmuJ_000953500   CDC7 cell division cycle 7
Giardia lamblia GL50803_112076   Kinase, CDC7
Homo sapiens ENSG00000097046   cell division cycle 7
Loa Loa (eye worm) LOAG_03017   CDC7 protein kinase
Mus musculus ENSMUSG00000029283   cell division cycle 7 (S. cerevisiae)
Oryza sativa 4349401   Os10g0563500
Onchocerca volvulus OVOC1780  
Onchocerca volvulus OVOC3268  
Saccharomyces cerevisiae YDL017W   Cdc7p
Schistosoma japonicum Sjp_0111110   ko:K02214 cell division control protein CDC7, putative
Schistosoma mansoni Smp_177120   serine/threonine protein kinase
Schmidtea mediterranea mk4.000196.02   Cdc7-like protein
Trichomonas vaginalis TVAG_202140   CMGC family protein kinase
Trichomonas vaginalis TVAG_199490   CMGC family protein kinase
Trichomonas vaginalis TVAG_373340   CMGC family protein kinase

Essentiality

Bm1_05720 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
YDL017W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens cell division cycle 7 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Patiria pectinifera Cdc2 300 aa 20.5% 254 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 21.7% 253 aa Compounds References
Sus scrofa Casein kinase I isoform alpha 125 aa 35.6% 104 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 21.8% 280 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.076 0.8307 0.8304
0.0093 0.8828 0
0.0023 0.5 0.5
0.057 0.6804 1
0.0039 0.9485 1
0.2196 0.2887 0.2887
0.057 0.518 0.5594
0.0293 0.5996 0.5996
0.0064 0.3377 0.3377
0.1003 0.9561 1
0.0694259 1 1
0.0131 0.4146 1
0.0059 1 1
0.1106 0.9641 0.9641
0.0655 0.3838 0.4654
0.0304 0.3579 1
0.0003 0.5 0.5
0.025 0.2706 0.2814
0.0993 0.572 0.6961
0.1233 0.296 1
0.0799 0.2612 0.2612
0.0294 0.3441 0.5954
0.019 0.5643 0.733
0.0066 0.3101 0
0.0432 0.4115 0.444
0.2124 0.2777 1
0.0007 0.5 0.5
0.0467 0.4664 1
0.1488 0.4188 0.456
0.0432 0.5276 0.5425
0.0016 0.5 0.5
0.0036 0.5 0.5
0.0289 0.6739 1
0.047 0.5298 1
0.0427 0.2853 0.2843
0.0443 0.5272 0.6221
0.0012 0.5 0.5
0.1583 0.2913 0.2912
0.0062 0.6935 0.7231
0.2094 0.6724 0.6723
0.1527 0.3751 0.3751
0.0655 0.3838 0.4654
0.101 0.7623 0.7622
0.0477 0.4013 0.4013
0.0091 1 1
0.139319 1 1
0.0633 0.9151 0.9149
0.0888 0.8222 0.8222
0.0039 0.2718 0.2718
0.032 0.34 0.6195
0.0098 0.3242 0.2614
0.0655 0.3838 0.4654
0.0032 0.5 0.5
0.0029 0.5 0.5
0.0242 0.2815 1
0.0407 0.4994 0.4994
0.0007 0.5 0.5
0.0483 0.4903 1
0.007 0.333 0.333
0.0059 1 1
0.025 0.2706 0.2814
0.1761 0.2645 0.2627
0.1583 0.2913 0.2912
0.0432 0.5276 0.5425
0.1198 0.3693 0.3693
0.2124 0.2777 1
0.0637 0.3419 0.429
0.0069 0.3427 0.3345
0.0655 0.3838 0.4654
0.0679 0.3704 0.4494
0.007 0.333 0.333
0.0037 1 0.5
0.0734844 1 1
0.1594 0.2817 0.2812
0.0069 0.3067 0.9179
0.1198 0.371 0.5528
0.0022 0.5 0.5
0.0542 0.5429 0.7348
0.0081 0.5 0.5
0.0069 0.6408 0.6258
0.0059 1 1
0.1972 0.9118 1
0.0326 0.2624 0.2838
0.1806 0.2505 0.2505
0.0116 0.3659 0.3659
0.0027 1 1
0.0655 0.3838 0.4654
0.0477 0.4013 0.4013
0.0069 0.3378 1
0.0637 0.3419 0.429
0.0032 0.5 0.5
0.0445 0.6136 0.6136
0.0353 0.2783 0.4971
0.0184 0.3639 1
0.0443 0.5272 0.6221
0.0117 0.6447 0.6313
0.0069 0.3739 0.6242
0.0067 0.5 0.5
0.0431 0.4349 1
0.0007 0.5 0.5
0.0786 0.8914 1
0.1493 0.344 0.4569
0.0069 0.5032 0.456
0.0682 0.7706 0.7706
0.0166783 1 1
0.0061 0.8224 1
0.0116 0.3659 0.3659
0.0069 0.2638 0.9899
0.0232 0.3305 1
0.2196 0.2887 0.2887
0.2196 0.2887 0.2887
0.0061 0.6883 0.6808
0.0063 0.7244 0
0.0437 0.6221 0.6209
0.0056 1 1
0.029 0.7941 1
0.0295 0.2964 0.3213
0.061 0.3549 0.5631
0.0081 1 1
0.061 0.3549 0.5631
0.025 0.2706 0.2814
0.0239 0.2646 0.9307
0.076 0.8307 0.8304
0.0427 0.2853 0.2843
0.0039 0.5 0.5
0.0423 0.3022 1
0.0012 0.5 0.5
0.0294 0.3441 0.5954
0.118923 1 1
0.1092 0.3222 0.3222
0.0477 0.4013 0.4013
0.0993 0.6069 0.6697
0.0071 0.2577 0.2682
0.1328 0.367 0.367
0.0302 0.3532 1
0.0323 0.2522 0.2722
0.1509 0.6391 0.6369
0.0295 0.9121 1
0.018 0.8345 1
0.007 0.333 0.333
0.0432 0.5276 0.5425
0.018 0.3138 0.3118
0.2196 0.2887 0.2887
0.1861 0.7918 0.7917
0.049 0.468 0.5056
0.0061 0.6048 0.6048
0.2827 0.2561 0.256
0.0121 0.2748 0.2748
0.0033 1 1
0.0012 0.5 0.5
0.1564 0.9603 0.9603
0.0315 0.2566 0.278
0.2124 0.2777 1
0.0232 0.9456 1
0.133 0.5669 0.5669
0.0004 0.5 0.5
0.0069 0.2889 0.4408
0.1428 0.3274 0.433
0.0655 0.3838 0.4654
0.0437 0.6175 0.6169
0.0011 1 1
0.0416 0.4039 0.4039
0.1032 0.2627 0.3097
0.1233 0.296 1
0.023 0.5116 0.5116
0.0069 0.5118 0.5118
0.0042 0.5 0.5
0.0421 0.4439 1
0.1509 0.6391 0.6369
0.0474 0.4044 0.4044
0.0008 0.5 0.5
0.0092 1 1
0.1802 0.9974 0.9974
0.0016 0.5 0.5
0.0939 0.9098 0.9611
0.0902 0.2787 1
0.0063 1 1
0.0633 0.9151 0.9149
0.1198 0.3693 0.3693
0.019 0.486 0.7154
0.0033 0.5 0.5
0.0026 0.5 0.5
0.0481 0.405 0.405
0.0088 0.4477 0.4477
0.0018 0.5 0.5
0.0039 0.5 0.5
0.0261 0.2797 0.5081
0.1509 0.6391 0.6369
0.2543 0.7576 1
0.0313 0.347 0.632

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_05720 (Brugia malayi), Protein kinase domain containing protein
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