Detailed view for Bm1_48215

Basic information

TDR Targets ID: 238126
Brugia malayi, Vacuolar h atpase protein 16
Source Database / ID:  GenBank

pI: 4.615 | Length (AA): 348 | MW (Da): 40210 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01992   ATP synthase (C/AC39) subunit

Gene Ontology

Mouse over links to read term descriptions.
GO:0033179   proton-transporting V-type ATPase, V0 domain  
GO:0015078   hydrogen ion transmembrane transporter activity  
GO:0015991   ATP hydrolysis coupled proton transport  
GO:0015986   ATP synthesis coupled proton transport  

Metabolic Pathways

Oxidative phosphorylation (KEGG)
Global map (KEGG)
Lysosome (KEGG)
Phagosome (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
10 347 1v9m (A) 5 322 17.00 0 1 1.17876 -0.66

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127683)

Species Accession Gene Product
Arabidopsis thaliana AT3G28710   V-type proton ATPase subunit d1
Arabidopsis thaliana AT3G28715   V-type proton ATPase subunit d2
Babesia bovis BBOV_II001540   vacuolar ATP synthase subunit d, putative
Brugia malayi Bm1_48215   Vacuolar h atpase protein 16
Candida albicans CaO19.364   vacuolar hydrogen-transporting ATPase VO domain
Candida albicans CaO19.7996   vacuolar hydrogen-transporting ATPase VO domain
Caenorhabditis elegans CELE_C30F8.2   Protein VHA-16
Cryptosporidium hominis Chro.50039   ATP synthase (C/AC39) subunit
Cryptosporidium parvum cgd5_3340   putative vacuolar ATP synthase subunit d
Dictyostelium discoideum DDB_G0273071   vacuolar ATPase subunit DVA41
Dictyostelium discoideum DDB_G0273657   vacuolar ATPase subunit DVA41
Drosophila melanogaster Dmel_CG2934   Vacuolar H[+] ATPase AC39 subunit 1
Drosophila melanogaster Dmel_CG4624   Vacuolar H[+] ATPase AC39 subunit 2
Echinococcus granulosus EgrG_000617100   vacuolar h atpase
Entamoeba histolytica EHI_106350   Vacuolar ATP synthase subunit d, putative
Echinococcus multilocularis EmuJ_000617100   vacuolar h atpase
Giardia lamblia GL50803_13000   Vacuolar ATP synthase subunit d
Homo sapiens ENSG00000147614   ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2
Homo sapiens ENSG00000159720   ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
Leishmania braziliensis LbrM.05.1140   vacuolar ATPase subunit-like protein
Leishmania donovani LdBPK_051140.1   V-type proton ATPase subunit D, putative
Leishmania infantum LinJ.05.1140   vacuolar ATPase subunit-like protein
Leishmania major LmjF.05.1140   vacuolar ATPase subunit-like protein
Leishmania mexicana LmxM.05.1140   vacuolar ATPase subunit-like protein
Loa Loa (eye worm) LOAG_01725   vacuolar h ATPase 16
Mus musculus ENSMUSG00000013160   ATPase, H+ transporting, lysosomal V0 subunit D1
Mus musculus ENSMUSG00000028238   ATPase, H+ transporting, lysosomal V0 subunit D2
Neospora caninum NCLIV_027480   hypothetical protein
Oryza sativa 4327660   Os01g0587000
Plasmodium berghei PBANKA_1328100   ATP synthase (C/AC39) subunit, putative
Plasmodium falciparum PF3D7_1464700   ATP synthase (C/AC39) subunit, putative
Plasmodium knowlesi PKNH_1216800   ATP synthase (C/AC39) subunit, putative
Plasmodium vivax PVX_117225   ATP synthase (C/AC39) subunit, putative
Plasmodium yoelii PY04403   ATP synthase subunit
Saccharomyces cerevisiae YLR447C   H(+)-transporting V0 sector ATPase subunit D
Schistosoma japonicum Sjp_0303140   ko:K02146 V-type H+-transporting ATPase subunit AC39, putative
Schistosoma mansoni Smp_079950   vacuolar ATP synthase subunit ac39
Schmidtea mediterranea mk4.001624.01   V-type proton ATPase subunit d 1
Trypanosoma brucei gambiense Tbg972.5.570   vacuolar ATP synthase, putative
Trypanosoma brucei Tb927.5.550   V-type proton ATPase subunit D, putative
Trypanosoma congolense TcIL3000_5_240   V-type proton ATPase subunit D, putative
Trypanosoma cruzi TcCLB.508397.10   V-type proton ATPase subunit D, putative
Trypanosoma cruzi TcCLB.509885.10   V-type proton ATPase subunit D, putative
Toxoplasma gondii TGME49_259010   vacuolar ATP synthase subunit d, putative
Theileria parva TP04_0436   vacuolar ATP synthase (C/AC39) subunit, putative
Trichomonas vaginalis TVAG_006020   vacuolar ATP synthase subunit ac39, putative

Essentiality

Bm1_48215 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.5.550 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.5.550 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.5.550 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.5.550 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_C30F8.2 Caenorhabditis elegans larval arrest wormbase
CELE_C30F8.2 Caenorhabditis elegans larval lethal wormbase
CELE_C30F8.2 Caenorhabditis elegans sterile wormbase
PBANKA_1328100 Plasmodium berghei Essential plasmo
TGME49_259010 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_48215 (Brugia malayi), Vacuolar h atpase protein 16
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