Detailed view for Bm1_39265

Basic information

TDR Targets ID: 241419
Brugia malayi, GH05862p
Source Database / ID:  GenBank

pI: 6.7322 | Length (AA): 179 | MW (Da): 21098 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF10183   ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

Oxidative phosphorylation (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_135648)

Species Accession Gene Product
Brugia malayi Bm1_39265   GH05862p
Caenorhabditis elegans CELE_F42G8.10   Protein F42G8.10, isoform B
Drosophila melanogaster Dmel_CG6008   CG6008 gene product from transcript CG6008-RA
Echinococcus granulosus EgrG_000998400   NADH dehydrogenase ubiquinone 1 beta
Echinococcus multilocularis EmuJ_000998400   NADH dehydrogenase (ubiquinone) 1 beta
Homo sapiens ENSG00000147123   NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
Loa Loa (eye worm) LOAG_00234   hypothetical protein
Mus musculus ENSMUSG00000031059   NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11
Onchocerca volvulus OVOC4954  
Schistosoma japonicum Sjp_0216590   Conserved hypothetical protein
Schistosoma mansoni Smp_080610   hypothetical protein
Schmidtea mediterranea mk4.004447.03   GH05862p

Essentiality

Bm1_39265 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F42G8.10 Caenorhabditis elegans embryonic lethal wormbase
CELE_F42G8.10 Caenorhabditis elegans larval arrest wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0385 0.3087 0.5783
0.0384 0.2768 0.5403
0.0382 0.2751 0.5334
0.023 0.2561 0.5139
0.0402 0.2767 0.5334
0.0393 0.2818 0.5459
0.0411 0.2753 0.5334
0.0394 0.2809 0.5453
0.0429 0.2503 0.5582
0.0385 0.3087 0.5783
0.0388 0.278 0.5418
0.0389 0.2799 0.5441

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_39265 (Brugia malayi), GH05862p
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