Detailed view for Bm1_36455

Basic information

TDR Targets ID: 243964
Brugia malayi, RasGEF domain containing protein
Source Database / ID:  GenBank

pI: 8.0972 | Length (AA): 1449 | MW (Da): 162884 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00595   PDZ domain (Also known as DHR or GLGF)
PF00617   RasGEF domain
PF00618   RasGEF N-terminal motif
PF00788   Ras association (RalGDS/AF-6) domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0005085   guanyl-nucleotide exchange factor activity  
GO:0005515   protein binding  
GO:0051056   regulation of small GTPase mediated signal transduction  
GO:0007264   small GTPase mediated signal transduction  
GO:0007165   signal transduction  

Metabolic Pathways

MAPK signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
61 1217 2byv (E) 15 976 29.00 0 1 0.623282 1.56
67 180 5e16 (A) 36 155 17.00 0 0.97 0.384475 -1.24
69 180 2ptm (A) 525 643 12.00 0 0.38 0.191095 -0.5
284 1194 3ksy (A) 77 981 14.00 0 1 0.657509 1.08
644 729 2fne (A) 1956 2043 35.00 0 1 0.592151 -1.86
657 701 1uit (A) 30 71 48.00 0.066 1 0.585856 -0.54
659 700 5f67 (A) 375 417 43.00 0.3 0.92 0.539786 -0.18

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130759)

Species Accession Gene Product
Brugia malayi Bm1_36455   RasGEF domain containing protein
Caenorhabditis elegans CELE_T14G10.2   Protein PXF-1, isoform C
Drosophila melanogaster Dmel_CG9491   PDZ domain-containing guanine nucleotide exchange factor
Echinococcus granulosus EgrG_001152650   rap guanine nucleotide exchange factor 6
Echinococcus multilocularis EmuJ_001152650   rap guanine nucleotide exchange factor 6
Homo sapiens ENSG00000109756   Rap guanine nucleotide exchange factor (GEF) 2
Homo sapiens ENSG00000158987   Rap guanine nucleotide exchange factor (GEF) 6
Loa Loa (eye worm) LOAG_04977   RasGEF domain-containing protein
Mus musculus ENSMUSG00000062232   Rap guanine nucleotide exchange factor (GEF) 2
Mus musculus ENSMUSG00000037533   Rap guanine nucleotide exchange factor (GEF) 6
Schistosoma japonicum Sjp_0019580   ko:K08018 Rap guanine nucleotide exchange factor (GEF) 2, putative
Schistosoma mansoni Smp_053100   pdz domain containing guanine nucleotide exchange factor pdz-gef
Schmidtea mediterranea mk4.010023.00   Rap guanine nucleotide exchange factor
Schmidtea mediterranea mk4.006628.00   Dizzy
Schmidtea mediterranea mk4.013414.00  
Schmidtea mediterranea mk4.000833.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_36455 (Brugia malayi), RasGEF domain containing protein
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