pI: 8.0655 |
Length (AA): 383 |
MW (Da): 40544 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
11 | 102 | 3cq1 (A) | 7 | 97 | 29.00 | 0.0016 | 1 | 0.750409 | -1.39 |
12 | 97 | 1uwd (A) | 8 | 101 | 38.00 | 0 | 1 | 0.722643 | -1.32 |
104 | 362 | 5aun (B) | 5 | 246 | 31.00 | 0 | 1 | 0.99634 | -0.41 |
113 | 336 | 5auq (E) | 13 | 224 | 40.00 | 0 | 1 | 0.905056 | -0.19 |
117 | 347 | 2ph1 (A) | 16 | 245 | 39.00 | 0 | 1 | 1.06323 | -0.4 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126620)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G24430 | protein high chlorophyll fluorescence 101 |
Arabidopsis thaliana | AT4G19540 | iron-sulfur protein required for NADH dehydrogenase |
Arabidopsis thaliana | AT5G50960 | nucleotide binding protein 35 |
Babesia bovis | BBOV_I000220 | conserved hypothetical protein |
Babesia bovis | BBOV_IV002290 | nucleotide-binding protein 1, putative |
Brugia malayi | Bm1_36105 | Mrp-family putative nucleotide-binding protein F10G8.6, putative |
Candida albicans | CaO19.8965 | similar to conserved putative nucleotide binding protein |
Candida albicans | CaO19.9591 | similar to uncharacterized conserved nucleotide binding protein found outside of yeast |
Candida albicans | CaO19.8367 | N terminus of NBP35-like orf |
Candida albicans | CaO19.8366 | C terminus of NBP35-like orf |
Candida albicans | CaO19.1387 | similar to conserved putative nucleotide binding protein |
Candida albicans | CaO19.747 | similar to essential evolutionarily conserved protein related to bacterial plasmid partitioning ATPases |
Candida albicans | CaO19.2043 | similar to uncharacterized conserved nucleotide binding protein found outside of yeast |
Caenorhabditis elegans | CELE_F10G8.6 | Protein NUBP-1 |
Cryptosporidium hominis | Chro.50297 | nucleotide-binding protein |
Cryptosporidium hominis | Chro.80366 | hypothetical protein |
Cryptosporidium parvum | cgd8_3140 | MRP like MinD family ATpase of the SIMIBI class of P-loop GTpases |
Cryptosporidium parvum | cgd5_900 | MRP like MinD family ATpase |
Dictyostelium discoideum | DDB_G0277437 | nucleotide binding protein 1 |
Dictyostelium discoideum | DDB_G0277157 | nucleotide binding protein 2 |
Dictyostelium discoideum | DDB_G0291193 | Mrp/NBP35 family protein |
Dictyostelium discoideum | DDB_G0285329 | nucleotide binding protein 1-like protein |
Drosophila melanogaster | Dmel_CG4858 | CG4858 gene product from transcript CG4858-RA |
Drosophila melanogaster | Dmel_CG3262 | CG3262 gene product from transcript CG3262-RE |
Drosophila melanogaster | Dmel_CG17904 | CG17904 gene product from transcript CG17904-RA |
Escherichia coli | b2113 | antiporter inner membrane protein |
Echinococcus granulosus | EgrG_000061000 | cytosolic Fe S cluster assembly factor nubp1 |
Echinococcus granulosus | EgrG_000126930 | putative nucleotide binding protein |
Echinococcus granulosus | EgrG_000126920 | cytosolic Fe S cluster assembly factor NUBP2 |
Echinococcus granulosus | EgrG_001016900 | nucleotide binding protein |
Entamoeba histolytica | EHI_047750 | Nucleotide-binding protein , putative |
Entamoeba histolytica | EHI_000610 | nucleotide binding protein 2, putative |
Echinococcus multilocularis | EmuJ_001016900 | nucleotide binding protein |
Echinococcus multilocularis | EmuJ_000061000 | cytosolic Fe S cluster assembly factor nubp1 |
Echinococcus multilocularis | EmuJ_000126910 | |
Giardia lamblia | GL50803_15324 | Nucleotide-binding protein 1 |
Giardia lamblia | GL50803_10969 | Nucleotide-binding protein 1 |
Homo sapiens | ENSG00000103274 | nucleotide binding protein 1 |
Homo sapiens | ENSG00000151413 | nucleotide binding protein-like |
Homo sapiens | ENSG00000095906 | nucleotide binding protein 2 |
Leishmania braziliensis | LbrM.21.0720 | nucleotide-binding protein, putative |
Leishmania braziliensis | LbrM.26.0450 | nucleotide binding protein-like protein |
Leishmania braziliensis | LbrM.28.2670 | MRP protein-like protein |
Leishmania donovani | LdBPK_210720.1 | nucleotide-binding protein, putative |
Leishmania donovani | LdBPK_282660.1 | MRP protein-like protein |
Leishmania donovani | LdBPK_260420.1 | nucleotide binding protein-like protein |
Leishmania infantum | LinJ.26.0420 | nucleotide binding protein-like protein |
Leishmania infantum | LinJ.21.0720 | nucleotide-binding protein, putative |
Leishmania infantum | LinJ.28.2660 | MRP protein-like protein |
Leishmania major | LmjF.28.2470 | MRP protein-like protein |
Leishmania major | LmjF.26.0430 | nucleotide binding protein-like protein |
Leishmania major | LmjF.21.0660 | nucleotide-binding protein, putative |
Leishmania mexicana | LmxM.26.0430 | nucleotide binding protein-like protein |
Leishmania mexicana | LmxM.21.0660 | nucleotide-binding protein, putative |
Leishmania mexicana | LmxM.28.2470 | MRP protein-like protein |
Loa Loa (eye worm) | LOAG_05712 | hypothetical protein |
Mycobacterium leprae | ML1080c | PROBABLE MRP-RELATED PROTEIN MRP |
Mus musculus | ENSMUSG00000039183 | nucleotide binding protein 2 |
Mus musculus | 76826 | nucleotide binding protein-like |
Mus musculus | ENSMUSG00000022503 | nucleotide binding protein 1 |
Mycobacterium tuberculosis | Rv1229c | Probable Mrp-related protein Mrp |
Mycobacterium ulcerans | MUL_4515 | Mrp-related protein Mrp |
Neospora caninum | NCLIV_010950 | ATP-binding protein, Mrp/Nbp35 family, related |
Neospora caninum | NCLIV_019460 | hypothetical protein |
Oryza sativa | 4329891 | Os02g0601100 |
Oryza sativa | 4324700 | Os01g0719700 |
Oryza sativa | 9271868 | Os03g0627300 |
Plasmodium berghei | PBANKA_0919700 | conserved protein, unknown function |
Plasmodium berghei | PBANKA_0811900 | cytosolic Fe-S cluster assembly factor NBP35, putative |
Plasmodium falciparum | PF3D7_0910800 | cytosolic Fe-S cluster assembly factor NBP35, putative |
Plasmodium falciparum | PF3D7_1128500 | conserved protein, unknown function |
Plasmodium knowlesi | PKNH_0926600 | conserved protein, unknown function |
Plasmodium knowlesi | PKNH_0708800 | cytosolic Fe-S cluster assembly factor NBP35, putative |
Plasmodium vivax | PVX_098980 | cytosolic Fe-S cluster assembly factor NBP35, putative |
Plasmodium vivax | PVX_092045 | hypothetical protein, conserved |
Plasmodium yoelii | PY03468 | nucleotide-binding protein |
Plasmodium yoelii | PY00852 | nucleotide-binding protein |
Saccharomyces cerevisiae | YGL091C | Nbp35p |
Saccharomyces cerevisiae | YIL003W | Cfd1p |
Schistosoma japonicum | Sjp_0302950 | Nucleotide binding protein 1, putative |
Schistosoma japonicum | Sjp_0089600 | Nucleotide-binding protein 2, putative |
Schistosoma mansoni | Smp_165770 | nucleotide-binding protein 1 (nbp 1)/nbp35 |
Schistosoma mansoni | Smp_154750 | nucleotide binding protein 2 (nbp 2) |
Schmidtea mediterranea | mk4.030023.00 | Cytosolic Fe-S cluster assembly factor NUBP1 homolog |
Schmidtea mediterranea | mk4.012841.00 | Cytosolic Fe-S cluster assembly factor NUBP1 homolog |
Schmidtea mediterranea | mk4.002482.03 | Iron-sulfur protein NUBPL |
Schmidtea mediterranea | mk4.004486.01 | |
Schmidtea mediterranea | mk4.011732.00 | Putative nucleotide-binding protein 1 |
Schmidtea mediterranea | mk4.017209.01 | Cytosolic Fe-S cluster assembly factor NUBP2 |
Schmidtea mediterranea | mk4.044940.01 | Iron-sulfur protein NUBPL |
Schmidtea mediterranea | mk4.001377.06 | Putative nucleotide binding protein 2 |
Trypanosoma brucei gambiense | Tbg972.10.2010 | nucleotide binding protein, putative |
Trypanosoma brucei gambiense | Tbg972.11.13160 | MRP protein, putative |
Trypanosoma brucei gambiense | Tbg972.7.1500 | nucleotide binding protein, putative |
Trypanosoma brucei | Tb927.11.11730 | MRP protein, putative |
Trypanosoma brucei | Tb927.10.1690 | cytosolic Fe-S cluster assembly factor NBP35, putative |
Trypanosoma brucei | Tb927.7.1500 | Cytosolic Fe-S cluster assembly factor CFD1, putative |
Trypanosoma congolense | TcIL3000.11.12390 | MRP protein, putative |
Trypanosoma congolense | TcIL3000_10_1430 | nucleotide binding protein, putative |
Trypanosoma congolense | TcIL3000_7_1010 | nucleotide binding protein, putative |
Trypanosoma cruzi | TcCLB.511911.150 | nucleotide-binding protein, putative |
Trypanosoma cruzi | TcCLB.507517.90 | nucleotide-binding protein, putative |
Trypanosoma cruzi | TcCLB.508637.110 | nucleotide-binding protein, putative |
Trypanosoma cruzi | TcCLB.511209.60 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.503579.100 | nucleotide-binding protein, putative |
Trypanosoma cruzi | TcCLB.506025.10 | hypothetical protein, conserved |
Toxoplasma gondii | TGME49_325500 | ATP-binding Mrp/Nbp35 family protein |
Toxoplasma gondii | TGME49_318590 | MRP family domain-containing protein |
Toxoplasma gondii | TGME49_280730 | cytosolic fe-s cluster assembling factor nbp35, putative |
Treponema pallidum | TP0853 | ATP-binding protein (ylxH-2) |
Theileria parva | TP03_0425 | nucleotide binding protein, putative |
Theileria parva | TP03_0848 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_277380 | nucleotide-binding protein, putative |
Trichomonas vaginalis | TVAG_076230 | nucleotide binding protein, putative |
Trichomonas vaginalis | TVAG_157490 | nucleotide binding protein, putative |
Trichomonas vaginalis | TVAG_178350 | nucleotide binding protein, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0063 | chromosome partitioning ATPase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1250 | Mycobacterium tuberculosis | essential | nmpdr |
Tb11.01.3600 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.3600 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.3600 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.3600 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.7.1500 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.1500 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.1500 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.1500 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.10.1690 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.1690 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.1690 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.1690 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b2113 | Escherichia coli | non-essential | goodall |
CELE_F10G8.6 | Caenorhabditis elegans | slow growth | wormbase |
YIL003W | Saccharomyces cerevisiae | inviable | yeastgenome |
YGL091C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0811900 | Plasmodium berghei | Essential | plasmo |
PBANKA_0919700 | Plasmodium berghei | Essential | plasmo |
TGME49_280730 | Toxoplasma gondii | Probably essential | sidik |
TGME49_318590 | Toxoplasma gondii | Probably essential | sidik |
TGME49_325500 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.