pI: 6.4585 |
Length (AA): 751 |
MW (Da): 83467 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 11 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
4 | 738 | 1ypw (A) | 25 | 741 | 22.00 | 0 | 1 | 0.87 | 0.71 |
54 | 738 | 1ypw (A) | 68 | 741 | 25.00 | 0 | 1 | 1.05 | 0.8 |
496 | 744 | 1d2n (A) | 505 | 748 | 40.00 | 0 | 1 | 0.95 | -1.57 |
1 | 198 | 1qcs (A) | 2 | 193 | 18.00 | 0 | 1 | 0.428948 | -0.29 |
2 | 192 | 1cr5 (A) | 26 | 208 | 23.00 | 0 | 1 | 0.457828 | -0.16 |
54 | 655 | 3cf2 (A) | 68 | 632 | 27.00 | 0 | 1 | 0.906898 | 1.11 |
244 | 490 | 5e7p (A) | 508 | 729 | 42.00 | 0 | 1 | 0.777095 | -0.47 |
401 | 487 | 3aji (B) | 337 | 406 | 31.00 | 0 | 1 | 0.384146 | -1.22 |
405 | 484 | 2dzn (D) | 349 | 411 | 29.00 | 0 | 0.85 | 0.258825 | -0.71 |
498 | 741 | 1d2n (A) | 507 | 745 | 42.00 | 0 | 1 | 0.9461 | -1.4 |
524 | 726 | 2gk6 (A) | 465 | 679 | 30.00 | 0.22 | 0.72 | 0.280506 | 0.93 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | VEG Tachyzoite, ME49 merozoite. | Gregory Hehl AB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | ME49 Tachyzoite, ME49 Bradyzoite. | Gregory Sibley/Greg |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | ME49 Oocyst. | Fritz HM |
Hehl AB | Asexual expansion of Toxoplasma gondii merozoites is distinct from tachyzoites and entails expression of non-overlapping gene families to attach, invade, and replicate within feline enterocytes. |
Sibley/Greg | ToxoDB |
Gregory | ToxoDB |
Fritz HM | Transcriptomic analysis of toxoplasma development reveals many novel functions and structures specific to sporozoites and oocysts. |
Ortholog group members (OG5_127665)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G04910 | N-ethylmaleimide sensitive factor |
Babesia bovis | BBOV_II007200 | N-ethylmaleimide-sensitive factor, putative |
Brugia malayi | Bm1_27160 | vesicle-fusing ATPase |
Candida albicans | CaO19.12461 | similar to C terminus of S. cerevisiae ATPase SEC18 (YBR080C) involved in protein transport between ER and Golgi |
Candida albicans | CaO19.4993 | similar to N terminus of S. cerevisiae ATPase SEC18 (YBR080C) involved in protein transport between ER and Golgi |
Candida albicans | CaO19.12460 | similar to N terminus of S. cerevisiae ATPase SEC18 (YBR080C) involved in protein transport between ER and Golgi |
Candida albicans | CaO19.4994 | similar to C terminus of S. cerevisiae ATPase SEC18 (YBR080C) involved in protein transport between ER and Golgi |
Caenorhabditis elegans | CELE_H15N14.2a | Protein NSF-1, isoform B |
Caenorhabditis elegans | CELE_H15N14.2 | Protein NSF-1, isoform A |
Cryptosporidium hominis | Chro.20314 | N-ethylmaleimide-sensitive factor; NSF; Sec18p |
Cryptosporidium parvum | cgd2_3010 | N-ethylmaleimide-sensitive factor (NSF1)-like AAA ATpase involved in vesicular transport |
Dictyostelium discoideum | DDB_G0276153 | N-ethylmaleimide-sensitive fusion protein |
Drosophila melanogaster | Dmel_CG1618 | comatose |
Drosophila melanogaster | Dmel_CG33101 | N-ethylmaleimide-sensitive factor 2 |
Echinococcus granulosus | EgrG_000338600 | vesicular fusion protein nsf |
Entamoeba histolytica | EHI_004640 | vesicle-fusing ATPase, putative |
Echinococcus multilocularis | EmuJ_000338600 | vesicular fusion protein nsf |
Giardia lamblia | GL50803_112681 | NSF |
Giardia lamblia | GL50803_114776 | NSF |
Homo sapiens | ENSG00000073969 | N-ethylmaleimide-sensitive factor |
Leishmania braziliensis | LbrM.20.4990 | vesicle-fusing ATPase, putative,N-ethylmaleimide-sensitive factor, putative |
Leishmania donovani | LdBPK_200820.1 | vesicular-fusion protein nsf, putative |
Leishmania infantum | LinJ.20.0820 | vesicle-fusing ATPase, putative,N-ethylmaleimide-sensitive factor, putative |
Leishmania major | LmjF.20.0810 | N-ethylmaleimide-sensitive factor, putative |
Leishmania mexicana | LmxM.20.0810 | vesicle-fusing ATPase, putative,N-ethylmaleimide-sensitive factor, putative |
Loa Loa (eye worm) | LOAG_10143 | vesicle-fusing ATPase |
Loa Loa (eye worm) | LOAG_11814 | vesicle-fusing ATPase |
Mus musculus | ENSMUSG00000034187 | N-ethylmaleimide sensitive fusion protein |
Neospora caninum | NCLIV_011040 | N-ethylmaleimide-sensitive factor, putative |
Oryza sativa | 4339340 | Os05g0519400 |
Plasmodium berghei | PBANKA_0401600 | N-ethylmaleimide-sensitive fusion protein, putative |
Plasmodium falciparum | PF3D7_0303000 | N-ethylmaleimide-sensitive fusion protein |
Plasmodium knowlesi | PKNH_0840100 | N-ethylmaleimide-sensitive fusion protein, putative |
Plasmodium vivax | PVX_119275 | N-ethylmaleimide-sensitive fusion protein, putative |
Plasmodium yoelii | PY05628 | ATPase, AAA family, putative |
Saccharomyces cerevisiae | YBR080C | AAA family ATPase SEC18 |
Schistosoma japonicum | Sjp_0210580 | ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative |
Schistosoma mansoni | Smp_057320 | vesicular-fusion protein nsf |
Schmidtea mediterranea | mk4.000372.04 | Vesicle-fusing ATPase |
Schmidtea mediterranea | mk4.000372.03 | |
Trypanosoma brucei gambiense | Tbg972.1.790 | N-ethylmaleimide sensitive factor (NsF),vesicular-fusion protein nsf, putative |
Trypanosoma brucei | Tb927.1.1560 | vesicular-fusion protein nsf, putative |
Trypanosoma congolense | TcIL3000_1_910 | vesicular-fusion protein nsf, putative |
Trypanosoma cruzi | TcCLB.508995.40 | vesicular-fusion protein nsf, putative |
Trypanosoma cruzi | TcCLB.506477.20 | vesicular-fusion protein nsf, putative |
Toxoplasma gondii | TGME49_318510 | N-ethylmaleimide-sensitive fusion protein, putative |
Theileria parva | TP02_0172 | N-ethylmaleimide sensitive protein, putative |
Trichomonas vaginalis | TVAG_476020 | vesicular-fusion protein nsf, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.1.1560 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.1.1560 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.1.1560 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.1.1560 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_H15N14.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_H15N14.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_H15N14.2 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_H15N14.2 | Caenorhabditis elegans | slow growth | wormbase |
CELE_H15N14.2 | Caenorhabditis elegans | sterile | wormbase |
YBR080C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0401600 | Plasmodium berghei | Essential | plasmo |
TGME49_318510 this record | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.