pI: 10.4481 |
Length (AA): 332 |
MW (Da): 36004 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 5
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | metacyclic. | Fernandes MC |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | amastigotes. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_128091)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G71940 | SNARE associated Golgi protein family |
Arabidopsis thaliana | AT4G09580 | SNARE associated Golgi protein family |
Arabidopsis thaliana | AT4G17790 | SNARE associated Golgi protein |
Brugia malayi | Bm1_06500 | KIAA0033 |
Caenorhabditis elegans | CELE_T07F10.4 | Protein BUS-19, isoform A |
Caenorhabditis elegans | CELE_D2013.10 | Protein TAG-175 |
Caenorhabditis elegans | CELE_Y71A12C.2 | Protein Y71A12C.2 |
Dictyostelium discoideum | DDB_G0275543 | hypothetical protein |
Drosophila melanogaster | Dmel_CG8408 | Stasimon |
Echinococcus granulosus | EgrG_001015200 | transmembrane protein 41B |
Echinococcus multilocularis | EmuJ_001015200 | transmembrane protein 41B |
Homo sapiens | ENSG00000166471 | transmembrane protein 41B |
Homo sapiens | ENSG00000163900 | transmembrane protein 41A |
Leishmania braziliensis | LbrM.12.0910 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_120810.1 | SNARE associated Golgi protein, putative |
Leishmania infantum | LinJ.12.0810 | hypothetical protein, conserved |
Leishmania major | LmjF.12.1230 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.12.1230 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_09667 | hypothetical protein |
Loa Loa (eye worm) | LOAG_16181 | hypothetical protein |
Loa Loa (eye worm) | LOAG_10196 | hypothetical protein |
Mus musculus | ENSMUSG00000047554 | transmembrane protein 41B |
Mus musculus | ENSMUSG00000022856 | transmembrane protein 41a |
Neospora caninum | NCLIV_038420 | hypothetical protein |
Oryza sativa | 4336832 | Os04g0592600 |
Oryza sativa | 4330389 | Os02g0693500 |
Oryza sativa | 4333847 | Os03g0703900 |
Onchocerca volvulus | OVOC1000 | Transmembrane protein 41A homolog |
Plasmodium berghei | PBANKA_0109300 | SNARE associated Golgi protein, putative |
Plasmodium falciparum | PF3D7_0611000 | SNARE associated Golgi protein, putative |
Plasmodium knowlesi | PKNH_1139400 | SNARE associated Golgi protein, putative |
Plasmodium vivax | PVX_113685 | SNARE associated Golgi protein, putative |
Plasmodium yoelii | PY03114 | Mus musculus RIKEN cDNA 5730578N08 gene |
Schistosoma japonicum | Sjp_0024840 | Transmembrane protein 41B, putative |
Schistosoma mansoni | Smp_000310.1 | D2013.10 |
Schistosoma mansoni | Smp_000310.2 | D2013.10 |
Schmidtea mediterranea | mk4.003386.03 | Transmembrane protein 41 homolog |
Schmidtea mediterranea | mk4.004190.03 | Transmembrane protein 41 homolog |
Schmidtea mediterranea | mk4.001266.03 | |
Trypanosoma brucei gambiense | Tbg972.1.3030 | SNARE-associated golgi protein, putative |
Trypanosoma brucei | Tb927.1.4500 | SNARE associated Golgi protein, putative |
Trypanosoma congolense | TcIL3000_1_1840 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.510885.20 | SNARE associated Golgi protein, putative |
Trypanosoma cruzi | TcCLB.506529.110 | SNARE associated Golgi protein, putative |
Toxoplasma gondii | TGME49_279370 | SNARE associated Golgi protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.1.4500 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.1.4500 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.1.4500 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.1.4500 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_279370 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.