Detailed view for Smp_069170

Basic information

TDR Targets ID: 282784
Schistosoma mansoni, cation efflux protein/ zinc transporter
Source Database / ID:  GeneDB

pI: 6.1445 | Length (AA): 473 | MW (Da): 51955 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 6

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01545   Cation efflux family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0016020   membrane  
GO:0008324   cation transmembrane transporter activity  
GO:0055085   transmembrane transport  
GO:0006812   cation transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
384 472 4kgq (C) 97 197 29.00 0.24 0.1 0.301061 0.18

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126754)

Species Accession Gene Product
Arabidopsis thaliana AT2G29410   metal tolerance protein B1
Arabidopsis thaliana AT2G46800   zinc transporter ZAT
Arabidopsis thaliana AT3G58810   metal tolerance protein A2
Brugia malayi Bm1_28605   cation diffusion facilitator family transporter containing protein
Brugia malayi Bm1_25275   cation efflux family protein
Brugia malayi Bm1_10905   cation diffusion facilitator family transporter containing protein
Candida albicans CaO19.9111   likely cation efflux pump (cadmium, zinc, cobalt), similar to S. cerevisiae COT1 (YOR316C) vacuolar transporter involved in zinc
Caenorhabditis elegans CELE_Y39E4A.2   Protein TTM-1, isoform B
Caenorhabditis elegans CELE_C15B12.7   Protein CDF-1, isoform A
Caenorhabditis elegans CELE_T18D3.3   Protein CDF-2
Cryptosporidium hominis Chro.10338   zinc transporter
Cryptosporidium parvum cgd1_3050   cation diffusion facilitator like membrane protein transporter, 6x transmembrane domains
Dictyostelium discoideum DDB_G0283629   cation diffusion facilitator family protein
Dictyostelium discoideum DDB_G0282067   cation diffusion facilitator family protein
Drosophila melanogaster Dmel_CG11163   Zinc transporter 41F
Drosophila melanogaster Dmel_CG31860   Zinc transporter 33D
Drosophila melanogaster Dmel_CG3994   Zinc transporter 35C
Drosophila melanogaster Dmel_CG17723   Zinc transporter 63C
Echinococcus granulosus EgrG_000860700   cation efflux protein: zinc transporter
Echinococcus granulosus EgrG_001187900   UDP glucose:glycoprotein glucosyltransferase
Entamoeba histolytica EHI_069990   zinc transporter, putative
Entamoeba histolytica EHI_110150   zinc/cadmium transporter, putative
Echinococcus multilocularis EmuJ_001187900   UDP glucose:glycoprotein glucosyltransferase
Echinococcus multilocularis EmuJ_000860700   cation efflux protein: zinc transporter
Giardia lamblia GL50803_13204   Zinc transporter domain
Homo sapiens ENSG00000158014   solute carrier family 30 (zinc transporter), member 2
Homo sapiens 7779   solute carrier family 30 (zinc transporter), member 1
Homo sapiens 55532   solute carrier family 30, member 10
Homo sapiens 7782   solute carrier family 30 (zinc transporter), member 4
Leishmania braziliensis LbrM.31.2680   zinc transporter-like protein
Leishmania donovani LdBPK_312470.1   zinc transporter, putative
Leishmania infantum LinJ.31.2470   zinc transporter-like protein
Leishmania major LmjF.31.2390   zinc transporter-like protein
Leishmania mexicana LmxM.30.2390   zinc transporter-like protein
Loa Loa (eye worm) LOAG_13237   hypothetical protein
Loa Loa (eye worm) LOAG_10145   cation efflux family protein
Loa Loa (eye worm) LOAG_07176   cation diffusion facilitator family transporter containing protein
Loa Loa (eye worm) LOAG_05585   hypothetical protein
Mus musculus ENSMUSG00000026614   solute carrier family 30, member 10
Mus musculus ENSMUSG00000005802   solute carrier family 30 (zinc transporter), member 4
Mus musculus ENSMUSG00000028836   solute carrier family 30 (zinc transporter), member 2
Mus musculus ENSMUSG00000037434   solute carrier family 30 (zinc transporter), member 1
Neospora caninum NCLIV_066710   Cation efflux system permease, related
Oryza sativa 4337694   Os05g0128400
Onchocerca volvulus OVOC7167  
Onchocerca volvulus OVOC2017  
Plasmodium berghei PBANKA_1422200   cation diffusion facilitator family protein, putative
Plasmodium falciparum PF3D7_0715900   cation diffusion facilitator family protein, putative
Plasmodium knowlesi PKNH_1424900   cation diffusion facilitator family protein, putative
Plasmodium vivax PVX_123000   cation diffusion facilitator transporter domain containing protein
Plasmodium yoelii PY07157   putative zinc transporter
Saccharomyces cerevisiae YMR243C   Zn(2+) transporter ZRC1
Saccharomyces cerevisiae YOR316C   metal cation transporter COT1
Schistosoma japonicum Sjp_0013440   ko:K03295 cation efflux system protein, CDF family, putative
Schistosoma japonicum Sjp_0023370   Zinc transporter 2, putative
Schistosoma mansoni Smp_176100   cation efflux protein/ zinc transporter
Schistosoma mansoni Smp_069170   cation efflux protein/ zinc transporter
Schmidtea mediterranea mk4.009044.02   Cation efflux protein/ zinc transporter,putative
Schmidtea mediterranea mk4.000077.04   Zinc transporter 1
Schmidtea mediterranea mk4.000411.00   Cation diffusion facilitator family protein 1
Schmidtea mediterranea mk4.000311.10   Zinc transporter 1
Schmidtea mediterranea mk4.003391.00   Cation efflux protein/ zinc transporter,putative
Schmidtea mediterranea mk4.000532.03  
Schmidtea mediterranea mk4.005399.00   Cation efflux protein/ zinc transporter,putative
Schmidtea mediterranea mk4.005399.01   Cation efflux protein/ zinc transporter,putative
Schmidtea mediterranea mk4.004391.01   Zinc transporter 1
Schmidtea mediterranea mk4.016315.00   Cation efflux protein/ zinc transporter,putative
Trypanosoma brucei gambiense Tbg972.8.7700   metal-ion transporter, putative
Trypanosoma brucei gambiense Tbg972.4.5140   metal-ion transporter, putative
Trypanosoma brucei Tb927.8.7460   zinc transporter, putative
Trypanosoma brucei Tb11.v5.0836   metal-ion transporter, putative
Trypanosoma brucei Tb927.4.4960   zinc transporter, putative
Trypanosoma congolense TcIL3000_8_7850   zinc transporter, putative
Trypanosoma congolense TcIL3000_8_7700   zinc transporter, putative
Trypanosoma cruzi TcCLB.510679.30   zinc transporter, putative
Trypanosoma cruzi TcCLB.511439.50   zinc transporter, putative
Toxoplasma gondii TGME49_251630   slc30a2 protein

Essentiality

Smp_069170 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.4960 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.4.4960 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.4.4960 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.4.4960 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.8.7460 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.7460 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.7460 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.7460 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y39E4A.2 Caenorhabditis elegans slow growth wormbase
PBANKA_1422200 Plasmodium berghei Dispensable plasmo
TGME49_251630 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier Smp_069170 (Schistosoma mansoni), cation efflux protein/ zinc transporter
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