Detailed view for Smp_075110

Basic information

TDR Targets ID: 282787
Schistosoma mansoni, rad1 DNA damage checkpoint protein
Source Database / ID:  GeneDB

pI: 4.8179 | Length (AA): 311 | MW (Da): 34388 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02144   Repair protein Rad1/Rec1/Rad17

Gene Ontology

Mouse over links to read term descriptions.
GO:0000077   DNA damage checkpoint  
GO:0005634   nucleus  
GO:0008853   exodeoxyribonuclease III activity  
GO:0003684   damaged DNA binding  
GO:0006281   DNA repair  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 270 3a1j (C) 13 275 45.00 0 1 1.42604 -0.41
11 299 3k4x (A) 6 300 13.00 0 1 1.02056 0.39

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130438)

Species Accession Gene Product
Arabidopsis thaliana AT4G17760   PCNA domain-containing protein
Brugia malayi Bm1_38895   Repair protein Rad1/Rec1/Rad17 containing protein
Caenorhabditis elegans CELE_Y41C4A.14   Protein MRT-2
Dictyostelium discoideum DDB_G0269378   checkpoint clamp complex protein
Drosophila melanogaster Dmel_CG3240   Radiation insensitive 1
Echinococcus granulosus EgrG_001006500   cell cycle checkpoint protein rad1
Echinococcus multilocularis EmuJ_001006500   cell cycle checkpoint protein rad1
Homo sapiens ENSG00000113456   RAD1 checkpoint DNA exonuclease
Loa Loa (eye worm) LOAG_04242   repair protein Rad1/Rec1/Rad17 containing protein
Mus musculus ENSMUSG00000022248   RAD1 homolog (S. pombe)
Oryza sativa 4340017   Os06g0132600
Schistosoma japonicum Sjp_0046930   Cell cycle checkpoint protein RAD1, putative
Schistosoma mansoni Smp_075110   rad1 DNA damage checkpoint protein
Schmidtea mediterranea mk4.000218.01   Cell cycle checkpoint protein RAD1
Schmidtea mediterranea mk4.000980.03  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens RAD1 checkpoint DNA exonuclease Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0129 0.8134 0.8107
0.0155 0.5233 0.532
0.0118 0.4574 0.4993
0.0151 0.8134 0.8013
0.0136 0.7932 0.7816

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_075110 (Schistosoma mansoni), rad1 DNA damage checkpoint protein
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