Detailed view for Smp_133390

Basic information

TDR Targets ID: 282802
Schistosoma mansoni, restin-like
Source Database / ID:  GeneDB

pI: 8.0578 | Length (AA): 1326 | MW (Da): 147674 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 8

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01302   CAP-Gly domain
PF06728   GPI transamidase subunit PIG-U
PF12796   Ankyrin repeats (3 copies)

Gene Ontology

Mouse over links to read term descriptions.
GO:0016255   attachment of GPI anchor to protein  
GO:0042765   GPI-anchor transamidase complex  
GO:0016021   integral to membrane  
GO:0005789   endoplasmic reticulum membrane  
GO:0005515   protein binding  
GO:0006506   GPI anchor biosynthetic process  

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
16 59 4rf6 (A) 28 75 39.00 0.98 0.4 0.325383 0.37
573 770 6fes (A) 30 194 34.00 0.00017 1 0.377521 0.01
883 942 1lpl (A) 150 210 48.00 0.000000000083 1 0.684449 -0.8
1024 1122 1whh (A) 3 101 47.00 0 1 0.619361 0.16
1045 1119 2coz (A) 30 104 49.00 0 1 0.671761 -0.6
1048 1117 2z0w (A) 12 81 59.00 0 0.99 0.67999 0.27
1049 1124 2cp0 (A) 19 94 47.00 0 1 0.654515 -0.62
1182 1268 2cow (A) 3 90 43.00 0 1 0.529311 0.47
1196 1272 2cp3 (A) 1 78 43.00 0 1 0.595769 -0.27
1198 1278 1whk (A) 8 90 52.00 0 1 0.622786 0.29
1199 1269 2cp0 (A) 13 84 39.00 0 0.97 0.526245 -0.05

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_140145)

Species Accession Gene Product
Echinococcus granulosus EgrG_000936600   Cytoskeleton associated protein CAP Gly containing ankyrin repeats
Echinococcus granulosus EgrG_001106100   cdc91 cell division cycle 91 1
Echinococcus multilocularis EmuJ_000936600   Cytoskeleton associated protein, CAP Gly, containing ankyrin repeats
Echinococcus multilocularis EmuJ_001106100   cdc91 cell division cycle 91 1
Homo sapiens ENSG00000115295   CAP-GLY domain containing linker protein family, member 4
Mus musculus ENSMUSG00000024059   CAP-GLY domain containing linker protein family, member 4
Schistosoma japonicum Sjp_0001210   ko:K10423 CAP-Gly domain-containing linker protein 3/4, putative
Schistosoma japonicum Sjp_0001240   ko:K05293 phosphatidylinositol glycan, class U, putative
Schistosoma mansoni Smp_133390   restin-like
Schmidtea mediterranea mk4.017865.00  
Schmidtea mediterranea mk4.004962.01   Restin-like
Schmidtea mediterranea mk4.003061.02  
Schmidtea mediterranea mk4.000131.11  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_133390 (Schistosoma mansoni), restin-like
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