Detailed view for Smp_131650

Basic information

TDR Targets ID: 282807
Schistosoma mansoni, hypothetical protein
Source Database / ID:  GeneDB

pI: 7.0934 | Length (AA): 1409 | MW (Da): 159555 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF10373   Est1 DNA/RNA binding domain
PF10374   Telomerase activating protein Est1
PF13638   PIN domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

mRNA surveillance pathway (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
350 1038 4um2 (A) 591 1148 40.00 0 1 0.477199 0.54
377 610 4um2 (A) 613 881 38.00 0 1 0.530575 -0.37
519 635 5hrz (A) 6 122 14.00 0.0000032 0.16 0.289138 -0.81
1147 1360 2dok (A) 1 184 49.00 0 1 0.558081 -0.74

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131595)

Species Accession Gene Product
Arabidopsis thaliana AT5G19400   EST1 domain protein SMG7
Brugia malayi Bm1_45270   hypothetical protein
Caenorhabditis elegans CELE_Y54F10AL.2   Protein SMG-6, isoform B
Drosophila melanogaster Dmel_CG6369   CG6369 gene product from transcript CG6369-RA
Echinococcus granulosus EgrG_000831300   telomerase binding protein EST1A
Echinococcus multilocularis EmuJ_000831300   telomerase binding protein EST1A
Homo sapiens ENSG00000070366   SMG6 nonsense mediated mRNA decay factor
Loa Loa (eye worm) LOAG_00974   hypothetical protein
Mus musculus ENSMUSG00000038290   Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
Oryza sativa 4345227   Os08g0305300
Schistosoma japonicum Sjp_0095600   expressed protein
Schistosoma japonicum Sjp_0310600   expressed protein
Schistosoma japonicum Sjp_0052560   ko:K09613 COP9 signalosome complex subunit 5, putative
Schistosoma mansoni Smp_131650   hypothetical protein
Schmidtea mediterranea mk4.012570.04   Telomerase-binding protein EST1A
Schmidtea mediterranea mk4.012570.03   Telomerase-binding protein EST1A
Schmidtea mediterranea mk4.006651.00   Telomerase-binding protein EST1A

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Smp_131650 (Schistosoma mansoni), hypothetical protein
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