Detailed view for Smp_127510
Basic information
Schistosoma mansoni, myosin XV
Source Database / ID: GeneDB
pI: 7.5114 |
Length (AA): 2448 |
MW (Da): 280121 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: Y | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
Gene Ontology
GO:0016459 myosin complex
GO:0008017 microtubule binding
GO:0005524 ATP binding
GO:0005515 protein binding
GO:0003777 microtubule motor activity
GO:0003774 motor activity
GO:0007018 microtubule-based movement
Metabolic Pathways
Structural information
Modbase 3D models:
There are 9 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 3 | 755 | 1g8x (A) | 113 | 860 | 32.00 | 0 | 1 | 0.524098 | 0.51 |
| 7 | 639 | 5w1a (A) | 117 | 792 | 34.00 | 0 | 1 | 0.593078 | -0.37 |
| 7 | 638 | 4byf (A) | 43 | 711 | 38.00 | 0 | 1 | 0.57667 | -0.11 |
| 7 | 625 | 1lkx (C) | 39 | 695 | 34.00 | 0 | 1 | 0.544859 | -0.07 |
| 875 | 1076 | 3pvl (A) | 1185 | 1393 | 26.00 | 0.82 | 0.96 | 0.368016 | -0.02 |
| 1059 | 1227 | 2c6x (A) | 31 | 185 | 32.00 | 0.55 | 0.09 | 0.0885359 | 0.97 |
| 1388 | 1886 | 5mv7 (A) | 1 | 2066 | 19.00 | 0 | 1 | 0.31924 | 0.4 |
| 1432 | 2443 | 4haw (C) | 4 | 1036 | 11.00 | 0 | 0.99 | 0.445399 | 0.48 |
| 1440 | 1548 | 5f3y (A) | 991 | 1134 | 30.00 | 0.026 | 0.74 | 0.411026 | -1.15 |
Help me make sense of these data.
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Expression
Orthologs
Ortholog group members (OG5_127340)
| Species | Accession | Gene Product |
|---|---|---|
| Brugia malayi | Bm1_30930 | MyTH4 domain containing protein |
| Brugia malayi | Bm1_30920 | Myosin head containing protein |
| Caenorhabditis elegans | CELE_T10H10.1 | Protein HUM-6 |
| Dictyostelium discoideum | DDB_G0274455 | class VII unconventional myosin |
| Drosophila melanogaster | Dmel_CG7595 | crinkled |
| Drosophila melanogaster | Dmel_CG43657 | Myosin 10A |
| Drosophila melanogaster | Dmel_CG6976 | Myosin 28B1 |
| Echinococcus granulosus | EgrG_001038000 | myosin XV |
| Echinococcus granulosus | EgrG_000821800 | myosin viia |
| Echinococcus multilocularis | EmuJ_000821800 | myosin viia |
| Echinococcus multilocularis | EmuJ_001038000 | myosin XV |
| Homo sapiens | ENSG00000137474 | myosin VIIA |
| Homo sapiens | ENSG00000091536 | myosin XVA |
| Homo sapiens | ENSG00000169994 | myosin VIIB |
| Homo sapiens | ENSG00000145555 | myosin X |
| Loa Loa (eye worm) | LOAG_13688 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_10785 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_02194 | MyTH4 domain-containing protein |
| Loa Loa (eye worm) | LOAG_02192 | myosin VIIa |
| Mus musculus | 102635076 | serine/arginine repetitive matrix protein 2-like |
| Mus musculus | ENSMUSG00000030761 | myosin VIIA |
| Mus musculus | ENSMUSG00000022272 | myosin X |
| Mus musculus | ENSMUSG00000024388 | myosin VIIB |
| Mus musculus | ENSMUSG00000042678 | myosin XV |
| Onchocerca volvulus | OVOC13442 |
|
| Schistosoma japonicum | Sjp_0025340 | Myosin-XV, putative |
| Schistosoma japonicum | Sjp_0092640 | Myosin-XV, putative |
| Schistosoma japonicum | Sjp_0060050 | Myosin-XV, putative |
| Schistosoma japonicum | Sjp_0101250 | IPR000857,Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4,domain-containing |
| Schistosoma mansoni | Smp_127510 | myosin XV |
| Schmidtea mediterranea | mk4.030143.00 | |
| Schmidtea mediterranea | mk4.002856.03 | Myosin-IB |
| Schmidtea mediterranea | mk4.002099.03 | |
| Schmidtea mediterranea | mk4.002099.02 | Unconventional myosin heavy chain 6 |
Essentiality
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Known modulators for this target
Predicted associations
By orthology with druggable targets
By sequence similarity to non orthologous druggable targets
Obtained from network model
Assayability
Assay information
Reagent availability
Bibliographic References