Detailed view for Smp_146060

Basic information

TDR Targets ID: 282852
Schistosoma mansoni, tuberin
Source Database / ID:  GeneDB

pI: 6.4409 | Length (AA): 2174 | MW (Da): 246892 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02145   Rap/ran-GAP

Gene Ontology

Mouse over links to read term descriptions.
GO:0043547   positive regulation of GTPase activity  
GO:0005634   nucleus  
GO:0005622   intracellular  
GO:0005096   GTPase activator activity  
GO:0051056   regulation of small GTPase mediated signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
613 1736 3s51 (A) 13 1212 11.00 0 0.97 0.477119 0.58
617 1316 2qna (A) 130 834 11.00 0 0.37 0.277087 0.05
1867 2149 1srq (B) 116 400 18.00 0 0.96 0.153275 0.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131251)

Species Accession Gene Product
Dictyostelium discoideum DDB_G0284825   RapGAP/RanGAP domain-containing protein
Drosophila melanogaster Dmel_CG5521   CG5521 gene product from transcript CG5521-RB
Echinococcus granulosus EgrG_000841700   ral GTPase activating protein subunit
Echinococcus multilocularis EmuJ_000841700   ral GTPase activating protein subunit
Homo sapiens ENSG00000188559   Ral GTPase activating protein, alpha subunit 2 (catalytic)
Homo sapiens ENSG00000174373   Ral GTPase activating protein, alpha subunit 1 (catalytic)
Mus musculus ENSMUSG00000021027   Ral GTPase activating protein, alpha subunit 1
Mus musculus ENSMUSG00000037110   Ral GTPase activating protein, alpha subunit 2 (catalytic)
Schistosoma japonicum Sjp_0056400   GTPase-activating Rap/Ran-GAP domain-like 1, putative
Schistosoma mansoni Smp_146060   tuberin
Schmidtea mediterranea mk4.000356.07   Probable Rho GTPase-activating protein CG5521

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_146060 (Schistosoma mansoni), tuberin
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