Detailed view for Smp_173010

Basic information

TDR Targets ID: 283075
Schistosoma mansoni, dro/myosuppressin receptor
Source Database / ID:  GeneDB

pI: 9.249 | Length (AA): 354 | MW (Da): 40724 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 7

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF10324   Serpentine type 7TM GPCR chemoreceptor Srw

Gene Ontology

Mouse over links to read term descriptions.
GO:0008528   peptide receptor activity, G-protein coupled  
GO:0016021   integral to membrane  
GO:0004930   G-protein coupled receptor activity  
GO:0007186   G-protein coupled receptor protein signaling pathway  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
33 353 2z73 (A) 26 339 14.00 0 0.56 1.03178 0.11
38 345 4uhr (A) 6 304 12.00 0.0013 0.03 0.923957 -0.01
55 337 6b73 (A) 77 338 22.00 0.00000028 0.72 0.936135 0.36
270 328 4p6v (E) 69 130 35.00 0.3 0.32 0.167367 2.32
286 345 3eml (A) 245 304 15.00 0.03 0.03 0.164392 1.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_138410)

Species Accession Gene Product
Brugia malayi Bm1_29620   AT19640p
Caenorhabditis elegans CELE_F57B7.1   Protein DMSR-1, isoform B
Caenorhabditis elegans CELE_C35A11.1   Protein DMSR-7
Drosophila melanogaster Dmel_CG43745   Myosuppressin receptor 2
Drosophila melanogaster Dmel_CG8985   Myosuppressin receptor 1
Echinococcus granulosus EgrG_000892500   dro:myosuppressin receptor
Echinococcus granulosus EgrG_000070900   dro:myosuppressin receptor
Echinococcus granulosus EgrG_000431100   dro:myosuppressin receptor
Echinococcus multilocularis EmuJ_000892500   dro:myosuppressin receptor
Echinococcus multilocularis EmuJ_000431100   dro:myosuppressin receptor
Echinococcus multilocularis EmuJ_000070900   dro:myosuppressin receptor
Loa Loa (eye worm) LOAG_12438   hypothetical protein
Loa Loa (eye worm) LOAG_11096   hypothetical protein
Loa Loa (eye worm) LOAG_03072   hypothetical protein
Schistosoma japonicum Sjp_0073490   IPR000276,Rhodopsin-like GPCR superfamily,domain-containing
Schistosoma japonicum Sjp_0038900   IPR000276,Rhodopsin-like GPCR superfamily,domain-containing
Schistosoma mansoni Smp_173010   dro/myosuppressin receptor
Schmidtea mediterranea mk4.013160.00  
Schmidtea mediterranea mk4.017680.00  
Schmidtea mediterranea mk4.001225.04  
Schmidtea mediterranea mk4.002460.05   Putative dro/myosuppressin receptor

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Thyrotropin-releasing hormone receptor 2 352 aa 23.7% 304 aa Compounds References
Oryctolagus cuniculus Adenosine A1 receptor 328 aa 22.7% 326 aa Compounds References
Rattus norvegicus Adenosine A1 receptor 326 aa 22.1% 326 aa Compounds References
Rattus norvegicus Adenosine receptor 332 aa 22.2% 324 aa Compounds References
Gallus gallus Adenosine A1 receptor 324 aa 24.2% 347 aa Compounds References
Cavia porcellus Adenosine A1 receptor 326 aa 21.3% 319 aa Compounds References
Rattus norvegicus Adenosine A2b receptor 332 aa 22.2% 324 aa Compounds References
Bos taurus Adenosine receptor A3 317 aa 20.3% 291 aa Compounds References
Sus scrofa A1 adenosine receptor 326 aa 23.0% 313 aa Compounds References
Bos taurus Rhodopsin 348 aa 19.1% 293 aa Compounds References
Rattus norvegicus Protein Gpr81 351 aa 22.1% 285 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Smp_173010 (Schistosoma mansoni), dro/myosuppressin receptor
Title for this comment
Comment