pI: 9.2514 |
Length (AA): 223 |
MW (Da): 25781 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 5
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_129130)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G03080 | lipid phosphate phosphatase gamma |
Candida albicans | CaO19.3682 | generation of mannoprotein layer of the cell wall |
Candida albicans | CaO19.11166 | generation of mannoprotein layer of the cell wall |
Dictyostelium discoideum | DDB_G0274591 | dolichyldiphosphatase 1 |
Echinococcus granulosus | EgrG_000116600 | dolichyldiphosphatase 1 |
Entamoeba histolytica | EHI_153110 | dolichyldiphosphatase, putative |
Echinococcus multilocularis | EmuJ_000116600 | dolichyldiphosphatase 1 |
Giardia lamblia | GL50803_2753 | Hypothetical protein |
Homo sapiens | ENSG00000167130 | dolichyldiphosphatase 1 |
Leishmania braziliensis | LbrM.30.0480 | dolichyl pyrophosphate phosphatase, putative |
Leishmania donovani | LdBPK_300410.1 | PAP2 family protein, putative |
Leishmania infantum | LinJ.30.0410 | dolichyl pyrophosphate phosphatase, putative |
Leishmania major | LmjF.30.0405 | dolichyl pyrophosphate phosphatase, putative |
Leishmania mexicana | LmxM.29.0405 | PAP2 family protein, putative |
Mus musculus | ENSMUSG00000026856 | dolichyl pyrophosphate phosphatase 1 |
Oryza sativa | 4332492 | Os03g0288700 |
Saccharomyces cerevisiae | YGR036C | Cax4p |
Schistosoma japonicum | Sjp_0203780 | ko:K07252 dolichyldiphosphatase [EC3.6.1.43], putative |
Schistosoma mansoni | Smp_048270.1 | dolichyldiphosphatase |
Schistosoma mansoni | Smp_048270.2 | dolichyldiphosphatase |
Schmidtea mediterranea | mk4.011351.00 | Dolichyldiphosphatase 1 |
Schmidtea mediterranea | mk4.005462.00 | |
Trypanosoma brucei gambiense | Tbg972.6.1520 | phosphatidic acid phosphatase, putative |
Trypanosoma brucei | Tb927.6.1820 | dolichyl pyrophosphate phosphatase, putative |
Trypanosoma congolense | TcIL3000_6_1410 | dolichyl pyrophosphate phosphatase, putative |
Trypanosoma cruzi | TcCLB.511491.130 | dolichyl pyrophosphate phosphatase, putative |
Trichomonas vaginalis | TVAG_313010 | paramyosin, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.1820 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.1820 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.1820 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.1820 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.