Detailed view for Smp_000670

Basic information

TDR Targets ID: 283291
Schistosoma mansoni, CENTB5 protein
Source Database / ID:  GeneDB

pI: 8.6104 | Length (AA): 1104 | MW (Da): 124122 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01412   Putative GTPase activating protein for Arf
PF12796   Ankyrin repeats (3 copies)
PF16746   BAR domain of APPL family

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  
GO:0008060   ARF GTPase activator activity  
GO:0005515   protein binding  
GO:0005096   GTPase activator activity  
GO:0032312   regulation of ARF GTPase activity  

Metabolic Pathways

Endocytosis (KEGG)

Structural information

Modbase 3D models:

There are 11 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
38 473 4nsw (A) 10 357 21.00 0 1 0.303828 1
57 230 4uos (A) 3 176 10.00 0.061 0.08 0.278409 -0.96
567 670 2p57 (A) 22 125 33.00 0 0.83 0.482103 -0.65
567 987 3lvq (E) 437 108 31.00 0 1 0.237741 1.16
567 960 3t9k (A) 416 720 47.00 0 0.72 0.250284 1.61
568 677 2iqj (A) 25 128 43.00 0 0.99 0.612038 -0.61
740 1052 4rly (A) 1125 2318 17.00 0 1 0.431314 0.39
773 1018 3b7b (A) 1 965 18.00 0 0.55 0.340626 0.44
816 898 3deo (A) 154 237 31.00 0.21 1 0.504581 -0.37
825 907 1n0q (A) 5 87 40.00 0.000000061 1 0.646581 -0.79
1005 1078 6g47 (A) 203 276 14.00 0 0.02 0.181929 -0.24

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127817)

Species Accession Gene Product
Arabidopsis thaliana AT1G10870   ADP-ribosylation factor GTPase-activating protein AGD4
Arabidopsis thaliana AT5G61980   ADP-ribosylation factor GTPase-activating protein AGD1
Arabidopsis thaliana AT1G60860   ADP-ribosylation factor GTPase-activating protein AGD2
Arabidopsis thaliana AT5G13300   ADP-ribosylation factor GTPase-activating protein AGD3
Brugia malayi Bm1_47060   GTP-ase activating protein for Arf containing protein
Candida albicans CaO19.3050   potential ADP ribosylation factor GTPase activating protein (ARF GAP) similar to S. cerevisiae AGE1 (YDR524C) ARF GAP with a rol
Candida albicans CaO19.10568   potential ADP ribosylation factor GTPase activating protein (ARF GAP) similar to S. cerevisiae AGE1 (YDR524C) ARF GAP with a rol
Caenorhabditis elegans CELE_Y17G7B.15   Protein CNT-1, isoform B
Dictyostelium discoideum DDB_G0275843   Arf GTPase activating protein
Dictyostelium discoideum DDB_G0279649   Arf GTPase activating protein
Dictyostelium discoideum DDB_G0276395   Arf GTPase activating protein
Drosophila melanogaster Dmel_CG6742   Centaurin beta 1A
Echinococcus granulosus EgrG_000969700   arf GAP with coiled coil ANK repeat and PH
Entamoeba histolytica EHI_152090   ARF GTPase activating protein, putative
Echinococcus multilocularis EmuJ_000969700   arf GAP with coiled coil, ANK repeat and PH
Homo sapiens ENSG00000131584   ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
Homo sapiens ENSG00000114331   ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
Homo sapiens ENSG00000072818   ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
Loa Loa (eye worm) LOAG_08699   GTP-ase activating protein for Arf containing protein
Mus musculus ENSMUSG00000029033   ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
Mus musculus ENSMUSG00000001588   ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
Mus musculus ENSMUSG00000049076   ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
Oryza sativa 4347541   Os09g0510700
Oryza sativa 4330061   Os02g0632500
Oryza sativa 4346168   Os08g0537600
Schistosoma japonicum Sjp_0013720   Centaurin-beta-2, putative
Schistosoma mansoni Smp_000670   CENTB5 protein
Schmidtea mediterranea mk4.000245.06   CENTB5 protein
Trichomonas vaginalis TVAG_256810   centaurin beta, putative
Trichomonas vaginalis TVAG_439740   centaurin alpha, putative
Trichomonas vaginalis TVAG_230890   centaurin/arf, putative
Trichomonas vaginalis TVAG_485110   development and differentiation-enhancing factor, ddef, putative
Trichomonas vaginalis TVAG_110580   centaurin gamma, putative

Essentiality

Smp_000670 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y17G7B.15 Caenorhabditis elegans larval lethal wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Smp_000670 (Schistosoma mansoni), CENTB5 protein
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