Detailed view for Smp_038030

Basic information

TDR Targets ID: 283388
Schistosoma mansoni, adenylosuccinate lyase
Source Database / ID:  GeneDB

pI: 7.6286 | Length (AA): 480 | MW (Da): 54501 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00206   Lyase
PF10397   Adenylosuccinate lyase C-terminus

Gene Ontology

Mouse over links to read term descriptions.
GO:0004018   adenylosuccinate lyase activity  
GO:0003824   catalytic activity  
GO:0009152   purine ribonucleotide biosynthetic process  

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 479 5eyv (A) 4 479 99.99 0 1 2.14997 -0.85

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 5EYT:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 5EYV:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128176)

Species Accession Gene Product
Brugia malayi Bm1_11585   adenylosuccinate lyase
Candida albicans CaO19.3870   Adenylosuccinate lyase
Candida albicans CaO19.11351   Adenylosuccinate lyase
Caenorhabditis elegans CELE_R06C7.5   Protein R06C7.5, isoform B
Drosophila melanogaster Dmel_CG3590   Adenylosuccinate Lyase
Echinococcus granulosus EgrG_000056300   adenylosuccinate lyase
Echinococcus granulosus EgrG_000054350   adenylosuccinate lyase
Echinococcus multilocularis EmuJ_000056300   adenylosuccinate lyase
Homo sapiens ENSG00000239900   adenylosuccinate lyase
Loa Loa (eye worm) LOAG_07404   hypothetical protein
Mycobacterium leprae ML2230c   PROBABLE ADENYLOSUCCINATE LYASE PURB (ADENYLOSUCCINASE) (ASL) (ASASE)
Mus musculus ENSMUSG00000022407   adenylosuccinate lyase
Mycobacterium tuberculosis Rv0777   Probable adenylosuccinate lyase PurB (adenylosuccinase) (ASL) (ASASE)
Mycobacterium ulcerans MUL_0490   adenylosuccinate lyase
Onchocerca volvulus OVOC11648   Adenylosuccinate lyase homolog
Saccharomyces cerevisiae YLR359W   adenylosuccinase ADE13
Schistosoma japonicum Sjp_0218820   ko:K01756 adenylosuccinate lyase [EC4.3.2.2], putative
Schistosoma japonicum Sjp_0312530   Adenylosuccinate lyase, putative
Schistosoma mansoni Smp_038030   adenylosuccinate lyase
Schmidtea mediterranea mk4.005122.00   Adenylosuccinate lyase
Wolbachia endosymbiont of Brugia malayi Wbm0503   adenylosuccinate lyase

Essentiality

Smp_038030 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_R06C7.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_R06C7.5 Caenorhabditis elegans larval arrest wormbase
CELE_R06C7.5 Caenorhabditis elegans slow growth wormbase
CELE_R06C7.5 Caenorhabditis elegans sterile wormbase
YLR359W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Smp_038030 (Schistosoma mansoni), adenylosuccinate lyase
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