pI: 7.193 |
Length (AA): 364 |
MW (Da): 41423 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 360 | 1r3s (A) | 11 | 362 | 55.00 | 0 | 1 | 1.75312 | -1.68 |
7 | 363 | 4zr8 (A) | 3 | 356 | 45.00 | 0 | 1 | 1.61087 | -1.47 |
8 | 360 | 4wsh (A) | 4 | 351 | 44.00 | 0 | 1 | 1.64188 | -1.79 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127347)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G40490 | Uroporphyrinogen decarboxylase |
Arabidopsis thaliana | AT3G14930 | uroporphyrinogen decarboxylase 1 |
Candida albicans | CaO19.5369 | uroporphyrinogen decarboxylase |
Candida albicans | CaO19.12829 | uroporphyrinogen decarboxylase |
Chlamydia trachomatis | CT_747 | uroporphyrinogen decarboxylase |
Dictyostelium discoideum | DDB_G0292294 | uroporphyrinogen decarboxylase |
Drosophila melanogaster | Dmel_CG1818 | CG1818 gene product from transcript CG1818-RA |
Escherichia coli | b3997 | uroporphyrinogen decarboxylase |
Echinococcus granulosus | EgrG_000492300 | uroporphyrinogen decarboxylase |
Echinococcus granulosus | EgrG_000492200 | uroporphyrinogen decarboxylase |
Echinococcus multilocularis | EmuJ_000492200 | uroporphyrinogen decarboxylase |
Echinococcus multilocularis | EmuJ_000492300 | uroporphyrinogen decarboxylase |
Homo sapiens | ENSG00000126088 | uroporphyrinogen decarboxylase |
Mycobacterium leprae | ML1043 | PROBABLE UROPORPHYRINOGEN DECARBOXYLASE HEME (UROPORPHYRINOGEN III DECARBOXYLASE) (URO-D) (UPD) |
Mus musculus | ENSMUSG00000028684 | uroporphyrinogen decarboxylase |
Mycobacterium tuberculosis | Rv2678c | Probable uroporphyrinogen decarboxylase HemE (uroporphyrinogen III decarboxylase) (URO-D) (UPD) |
Mycobacterium ulcerans | MUL_3312 | uroporphyrinogen decarboxylase |
Neospora caninum | NCLIV_042300 | Uroporphyrinogen decarboxylase (EC 4.1.1.37), related |
Oryza sativa | 9268639 | Os03g0340001 |
Oryza sativa | 4332771 | Os03g0337600 |
Oryza sativa | 4326635 | Os01g0622300 |
Plasmodium berghei | PBANKA_0105900 | uroporphyrinogen III decarboxylase |
Plasmodium falciparum | PF3D7_0607300 | uroporphyrinogen III decarboxylase |
Plasmodium knowlesi | PKNH_1143000 | uroporphyrinogen III decarboxylase, putative |
Plasmodium vivax | PVX_113530 | uroporphyrinogen III decarboxylase, putative |
Plasmodium yoelii | PY02528 | uroporphyrinogen decarboxylase, putative |
Saccharomyces cerevisiae | YDR047W | uroporphyrinogen decarboxylase HEM12 |
Schistosoma japonicum | Sjp_0084260 | ko:K01599 uroporphyrinogen decarboxylase [EC4.1.1.37], putative |
Schistosoma mansoni | Smp_143740 | uroporphyrinogen decarboxylase |
Schmidtea mediterranea | mk4.002378.01 | Uroporphyrinogen decarboxylase |
Schmidtea mediterranea | mk4.044698.00 | Uroporphyrinogen decarboxylase |
Schmidtea mediterranea | mk4.014694.00 | Uroporphyrinogen decarboxylase |
Toxoplasma gondii | TGME49_289940 | uroporphyrinogen decarboxylase |
Wolbachia endosymbiont of Brugia malayi | Wbm0001 | uroporphyrinogen-III decarboxylase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
b3997 | Escherichia coli | essential | goodall |
YDR047W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0105900 | Plasmodium berghei | Dispensable | plasmo |
TGME49_289940 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.